Probenecid

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What is Probenecid

Probenecid is an oral uricosuric agent used to treat hyperuricemia associated with chronic gout or secondary to other causes (e.g., drug-induced hyperuricemia).

Probenecid is not effective for acute attacks of gout and actually can aggravate inflammation if administered during the initial stages.

The drug may be coadminstered with colchicine or selected antibiotics to delay the renal clearance of these drugs, thereby elevating and prolonging serum concentrations when necessary for certain patients.

Probenecid was approved by the FDA in 1951.

Indications

  • adjuvant to antibiotic therapy
  • cidofovir toxicity prophylaxis
  • gout
  • gouty arthritis
  • hyperuricemia

For the treatment of hyperuricemia associated with chronic gout or gouty arthritis

Side Effects

  1. alopecia
  2. anaphylactoid reactions
  3. anemia
  4. anorexia
  5. aplastic anemia
  6. costovertebral pain
  7. dizziness
  8. fever
  9. flushing
  10. gout
  11. headache
  12. hematuria
  13. hemolytic anemia
  14. hepatic necrosis
  15. leukopenia
  16. nausea
  17. nephrolithiasis
  18. nephrotic syndrome
  19. polyuria
  20. pruritus
  21. urticaria
  22. vomiting

Monitoring Parameters

  • serum creatinine/BUN
  • serum uric acid
  • urinalysis

Contraindications

  • acid/base imbalance
  • anemia
  • aplastic anemia
  • breast-feeding
  • children
  • G6PD deficiency
  • geriatric
  • hematological disease
  • hemolytic anemia
  • infants
  • laboratory test interference
  • neonates
  • nephrolithiasis
  • peptic ulcer disease
  • pregnancy
  • probenecid hypersensitivity
  • renal failure
  • renal impairment
  • sulfonamide hypersensitivity
  • tumor lysis syndrome (TLS)

Interactions

  • Abacavir; Lamivudine, 3TC; Zidovudine, ZDV
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acyclovir
  • Allopurinol
  • Alprazolam
  • Aminosalicylate sodium, Aminosalicylic acid
  • Amitriptyline; Chlordiazepoxide
  • Amlodipine; Celecoxib
  • Amoxicillin
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Amoxicillin; Clavulanic Acid
  • Ampicillin
  • Ampicillin; Sulbactam
  • Aspirin, ASA
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Dipyridamole
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Aspirin, ASA; Pravastatin
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Baricitinib
  • Benzodiazepines
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Bictegravir; Emtricitabine; Tenofovir Alafenamide
  • Bismuth Subsalicylate
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Bromocriptine
  • Bumetanide
  • Cabozantinib
  • Captopril
  • Captopril; Hydrochlorothiazide, HCTZ
  • Carbacephems
  • Carbenicillin
  • Carbidopa; Levodopa; Entacapone
  • Cefaclor
  • Cefditoren
  • Cefotaxime
  • Cefpodoxime
  • Cefprozil
  • Ceftazidime; Avibactam
  • Ceftolozane; Tazobactam
  • Celecoxib
  • Cephalexin
  • Chlordiazepoxide
  • Chlordiazepoxide; Clidinium
  • Choline Salicylate; Magnesium Salicylate
  • Cidofovir
  • Ciprofloxacin
  • Clofarabine
  • Clonazepam
  • Clorazepate
  • Dapsone
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Deferiprone
  • Diazepam
  • Diazoxide
  • Dichlorphenamide
  • Diclofenac
  • Diclofenac; Misoprostol
  • Dicloxacillin
  • Diflunisal
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Doravirine; Lamivudine; Tenofovir disoproxil fumarate
  • Doripenem
  • Dyphylline
  • Dyphylline; Guaifenesin
  • Efavirenz; Emtricitabine; Tenofovir
  • Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
  • Eluxadoline
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Emtricitabine; Rilpivirine; Tenofovir alafenamide
  • Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
  • Emtricitabine; Tenofovir alafenamide
  • Emtricitabine; Tenofovir disoproxil fumarate
  • Entacapone
  • Ertapenem
  • Erythromycin; Sulfisoxazole
  • Esomeprazole; Naproxen
  • Estazolam
  • Ethacrynic Acid
  • Ethambutol
  • Ethanol
  • Etodolac
  • Famciclovir
  • Famotidine; Ibuprofen
  • Fenoprofen
  • Flurazepam
  • Flurbiprofen
  • Furosemide
  • Ganciclovir
  • Gemifloxacin
  • Glycerol Phenylbutyrate
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrocodone; Ibuprofen
  • Hydroxyurea
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Ibuprofen
  • Ibuprofen; Oxycodone
  • Ibuprofen; Pseudoephedrine
  • Imipenem; Cilastatin
  • Imipenem; Cilastatin; Relebactam
  • Indomethacin
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Ketoprofen
  • Ketorolac
  • Lamivudine, 3TC; Zidovudine, ZDV
  • Lamivudine; Tenofovir Disoproxil Fumarate
  • Lansoprazole; Naproxen
  • Lesinurad; Allopurinol
  • Levetiracetam
  • Lomefloxacin
  • Loracarbef
  • Lorazepam
  • Lumateperone
  • Magnesium Salicylate
  • Maraviroc
  • Mecamylamine
  • Meclofenamate Sodium
  • Mefenamic Acid
  • Meloxicam
  • Meropenem
  • Meropenem; Vaborbactam
  • Methotrexate
  • Midazolam
  • Mycophenolate
  • Nabumetone
  • Nafcillin
  • Naproxen
  • Naproxen; Pseudoephedrine
  • Naproxen; Sumatriptan
  • Nitrofurantoin
  • Norfloxacin
  • Omeprazole; Amoxicillin; Rifabutin
  • Oseltamivir
  • Oxacillin
  • Oxaprozin
  • Oxazepam
  • Pegloticase
  • Penicillin G
  • Penicillin G Benzathine
  • Penicillin G Benzathine; Penicillin G Procaine
  • Penicillin G Procaine
  • Penicillin V
  • Penicillins
  • Pexidartinib
  • Phentermine; Topiramate
  • Piperacillin
  • Piperacillin; Tazobactam
  • Piroxicam
  • Pralatrexate
  • Pyrazinamide, PZA
  • Pyrimethamine; Sulfadoxine
  • Quazepam
  • Rifampin
  • Rofecoxib
  • Salicylates
  • Salsalate
  • Silodosin
  • Sodium Benzoate; Sodium Phenylacetate
  • Sodium Phenylbutyrate
  • Stavudine, d4T
  • Sulfadiazine
  • Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
  • Sulfasalazine
  • Sulfinpyrazone
  • Sulfisoxazole
  • Sulfonamides
  • Sulfonylureas
  • Sulindac
  • Temazepam
  • Tenofovir Alafenamide
  • Tenofovir Alafenamide
  • Tenofovir, PMPA
  • Thiazide diuretics
  • Thiopental
  • Ticarcillin
  • Ticarcillin; Clavulanic Acid
  • Tolmetin
  • Topiramate
  • Triamterene
  • Triazolam
  • Valacyclovir
  • Valdecoxib
  • Valganciclovir
  • Zalcitabine, ddC
  • Zidovudine, ZDV

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