Probucol

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What is Probucol

NOTE: This drug is discontinued in the US.

Probucol is an oral antilipemic agent used in the treatment of primary hypercholesterolemia.

Probucol is a substituted bis-phenol structurally unrelated to other currently available antilipemic agents. It exerts its antilipemic action mainly on cholesterol, with relatively little effect on triglycerides.

Probucol was approved by the FDA in 1977, then was removed from the US market in November 1995 over concerns that it lowered HDL cholesterol, however, it remains available elsewhere.

Probucol has been associated with QT prolongation. In August 1997, a Canadian study showed probucol was superior to antioxidant vitamins in ability to reduce progression of atherosclerosis post-angioplasty.

Indications

  1. atherosclerosis
  2. hypercholesterolemia
  3. hyperlipoproteinemia

For the treatment of primary hypercholesterolemia (type IIa hyperlipoproteinemia)

Side Effects

  1. abdominal pain
  2. anemia
  3. angina
  4. angioedema
  5. diarrhea
  6. dizziness
  7. elevated hepatic enzymes
  8. eosinophilia
  9. nausea
  10. palpitations
  11. QT prolongation
  12. syncope
  13. thrombocytopenia
  14. torsade de pointes
  15. ventricular fibrillation
  16. ventricular tachycardia
  17. vomiting

Monitoring Parameters

  • serum lipid profile

Contraindications

  • AV block
  • biliary cirrhosis
  • bradycardia
  • breast-feeding
  • cardiac arrhythmias
  • children
  • cholelithiasis
  • hypokalemia
  • hypomagnesemia
  • infants
  • myocardial infarction
  • neonates
  • pregnancy
  • QT prolongation
  • syncope
  • torsade de pointes
  • ventricular arrhythmias

Interactions

No information is available regarding drug interactions associated with Probucol 

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