What's on this Page
Prednisolone and Sulfacetamide Brand Names
Blephamide | Blephamide S.O.P. | Cetapred | Metimyd | Ocu-Lone C | Optimyd | Sulster | Vasocidin
What is Prednisolone and Sulfacetamide
Prednisolone and sulfacetamide are used together in ophthalmic preparations for steroid-responsive inflammatory ocular conditions where bacterial infection or a risk of bacterial ocular infection exists.
Prednisolone is a glucocorticoid antiinflammatory agent.
Sulfacetamide is an antimicrobial agent that exerts a bacteriostatic effect by restricting the synthesis of folic acid through competition with p-aminobenzoic acid.
Sulfacetamide is active in vitro against susceptible strains of the following microorganisms: Enterobacter sp., Escherichia coli, Haemophilus influenza, Klebsiella sp., Staphylococcus aureus, Streptococcus pneumoniae, and Viridans streptococci.
Prolonged use of topical corticosteroids can lead to systemic absorption and increase the risk of secondary ocular infections.
Indications
- bacterial conjunctivitis
- corneal abrasion
- Enterobacter sp.
- Escherichia coli
- Haemophilus influenzae (beta-lactamase negative)
- Klebsiella sp.
- ocular inflammation
- Staphylococcus aureus (MSSA)
- Streptococcus pneumoniae
- uveitis
- Viridans streptococci
Side Effects
- agranulocytosis
- aplastic anemia
- blurred vision
- cataracts
- dizziness
- erythema
- hepatic necrosis
- hyperemia
- impaired wound healing
- mydriasis
- ocular discharge
- ocular hypertension
- ocular infection
- ocular irritation
- ocular pain
- ocular pruritus
- pruritus
- ptosis
- rash
- Stevens-Johnson syndrome
- superinfection
- toxic epidermal necrolysis
- urticaria
- uveitis
Monitoring Parameters
- intraocular pressure
- ophthalmologic exam
Contraindications
- abrupt discontinuation
- Black patients
- breast-feeding
- cataracts
- children
- contact lenses
- corticosteroid hypersensitivity
- corticosteroid withdrawal
- fungal infection
- glaucoma
- herpes simplex keratitis (dendritic keratitis)
- increased intraocular pressure
- infants
- intramuscular administration
- intravenous administration
- mycobacterial infection
- neonates
- ocular infection
- ocular surgery
- pregnancy
- sulfonamide hypersensitivity
- thimerosal hypersensitivity
- uveitis
- varicella
- viral infection
- visual disturbance
Interactions
There are no drug interactions associated with Prednisolone and Sulfacetamide products.
