Prazosin

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Prazosin Brand Name– Minipress

What is Prazosin

Prazosin is an oral agent used primarily to treat hypertension. It is classified as a quinazoline and is similar to the other alpha1-antagonists doxazosin and terazosin, both of which are longer acting than prazosin.

Prazosin has been used off-label to treat benign prostatic hypertrophy (BPH).

Prazosin also has been used in the treatment of heart failure; however, due to the development of tolerance, prazosin is seldom used for this condition today.

Prazosin was approved by the FDA in 1976.

Indications

  • benign prostatic hyperplasia (BPH)
  • hypertension
  • hypertensive urgency
  • posttraumatic stress disorder (PTSD)
  • Raynaud’s phenomenon

For the treatment of hypertension

Side Effects

  1. abdominal pain
  2. alopecia
  3. angina
  4. anxiety
  5. arthralgia
  6. asthenia
  7. blurred vision
  8. bradycardia
  9. constipation
  10. depression
  11. diaphoresis
  12. diarrhea
  13. dizziness
  14. drowsiness
  15. dyspnea
  16. edema
  17. elevated hepatic enzymes
  18. epistaxis
  19. fatigue
  20. fever
  21. floppy iris syndrome
  22. flushing
  23. gynecomastia
  24. hallucinations
  25. headache
  26. hyperemia
  27. hypotension
  28. impotence (erectile dysfunction)
  29. increased urinary frequency
  30. insomnia
  31. lichen planus-like eruption
  32. malaise
  33. nasal congestion
  34. nausea
  35. ocular pain
  36. orthostatic hypotension
  37. palpitations
  38. pancreatitis
  39. paresthesias
  40. peripheral edema
  41. priapism
  42. pruritus
  43. rash
  44. sinus tachycardia
  45. syncope
  46. tinnitus
  47. urinary incontinence
  48. urticaria
  49. vasculitis
  50. vertigo
  51. vomiting
  52. weakness
  53. xerostomia

Monitoring Parameters

  • blood pressure

Contraindications

  • angina
  • breast-feeding
  • geriatric
  • hypotension
  • ocular surgery
  • orthostatic hypotension
  • pregnancy
  • priapism
  • syncope

Interactions

  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetaminophen; Pseudoephedrine
  • Acrivastine; Pseudoephedrine
  • Aldesleukin, IL-2
  • Alemtuzumab
  • Alfuzosin
  • Aliskiren
  • Aliskiren; Amlodipine
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Aliskiren; Valsartan
  • Alprostadil
  • Ambrisentan
  • Amifostine
  • Amlodipine
  • Amlodipine; Atorvastatin
  • Amlodipine; Benazepril
  • Amlodipine; Celecoxib
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
  • Amobarbital
  • Amphetamines
  • Amyl Nitrite
  • Angiotensin II receptor antagonists
  • Angiotensin-converting enzyme inhibitors
  • Apomorphine
  • Apraclonidine
  • Aripiprazole
  • Articaine; Epinephrine
  • Asenapine
  • Avanafil
  • Azilsartan
  • Azilsartan; Chlorthalidone
  • Baclofen
  • Benazepril
  • Benazepril; Hydrochlorothiazide, HCTZ
  • Beta-blockers
  • Bortezomib
  • Bosentan
  • Brexpiprazole
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Dextromethorphan; Phenylephrine
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Brompheniramine; Pseudoephedrine
  • Cabergoline
  • Calcium-channel blockers
  • Candesartan
  • Candesartan; Hydrochlorothiazide, HCTZ
  • Captopril
  • Captopril; Hydrochlorothiazide, HCTZ
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbetapentane; Pseudoephedrine
  • Carbidopa; Levodopa
  • Carbidopa; Levodopa; Entacapone
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Phenylephrine
  • Carbinoxamine; Pseudoephedrine
  • Cariprazine
  • Central-acting adrenergic agents
  • Cetirizine; Pseudoephedrine
  • Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
  • Chlophedianol; Guaifenesin; Phenylephrine
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
  • Chlorthalidone; Clonidine
  • Clevidipine
  • Clonidine
  • Clozapine
  • Co-Enzyme Q10, Ubiquinone
  • Codeine; Phenylephrine; Promethazine
  • Darolutamide
  • Desloratadine; Pseudoephedrine
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dexmethylphenidate
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Guaifenesin; Phenylephrine
  • Dextromethorphan; Guaifenesin; Pseudoephedrine
  • Dextromethorphan; Quinidine
  • Diazoxide
  • Diethylpropion
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Diltiazem
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Phenylephrine
  • Dobutamine
  • Dopamine
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Duloxetine
  • Dutasteride; Tamsulosin
  • Enalapril, Enalaprilat
  • Enalapril; Felodipine
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Enflurane
  • Ephedrine
  • Epinephrine
  • Eplerenone
  • Epoprostenol
  • Eprosartan
  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Estradiol
  • Estradiol Cypionate; Medroxyprogesterone
  • Ethanol
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • Etomidate
  • Felodipine
  • Fenoldopam
  • Fexofenadine; Pseudoephedrine
  • Fish Oil, Omega-3 Fatty Acids (Dietary Supplements)
  • Fosinopril
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Fospropofol
  • General anesthetics
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Guaifenesin; Phenylephrine
  • Guaifenesin; Pseudoephedrine
  • Guanabenz
  • Guanfacine
  • Haloperidol
  • Halothane
  • Hydralazine
  • Hydralazine; Hydrochlorothiazide, HCTZ
  • Hydralazine; Isosorbide Dinitrate, ISDN
  • Hydrochlorothiazide, HCTZ; Irbesartan
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Ibuprofen; Pseudoephedrine
  • Iloperidone
  • Iloprost
  • Indapamide
  • Intravenous Lipid Emulsions
  • Irbesartan
  • Isocarboxazid
  • Isoflurane
  • Isoproterenol
  • Isosorbide Dinitrate, ISDN
  • Isosorbide Mononitrate
  • Isradipine
  • Ketamine
  • Levodopa
  • Lisinopril
  • Lofexidine
  • Loop diuretics
  • Loratadine; Pseudoephedrine
  • Losartan
  • Lovastatin; Niacin
  • Lurasidone
  • Mecamylamine
  • Mestranol; Norethindrone
  • Methohexital
  • Methyldopa
  • Methylphenidate
  • Midodrine
  • Milrinone
  • Minoxidil
  • Moexipril
  • Naproxen; Pseudoephedrine
  • Nebivolol; Valsartan
  • Nesiritide, BNP
  • Niacin, Niacinamide
  • Niacin; Simvastatin
  • Nicardipine
  • Nicotine
  • Nifedipine
  • Nimodipine
  • Nisoldipine
  • Nitrates
  • Nitroglycerin
  • Nitroprusside
  • Nonsteroidal antiinflammatory drugs
  • Norepinephrine
  • Olmesartan
  • Oxymetazoline
  • Paliperidone
  • Pentoxifylline
  • Perindopril
  • Perindopril; Amlodipine
  • Phendimetrazine
  • Phenelzine
  • Phentermine
  • Phentermine; Topiramate
  • Phenylephrine
  • Phenylephrine; Promethazine
  • Potassium-sparing diuretics
  • Prilocaine; Epinephrine
  • Procainamide
  • Procaine
  • Propofol
  • Pseudoephedrine
  • Quinapril
  • Quinidine
  • Ramipril
  • Rasagiline
  • Reserpine
  • Risperidone
  • Ritodrine
  • Sacubitril; Valsartan
  • Segesterone Acetate; Ethinyl Estradiol
  • Sevoflurane
  • Sildenafil
  • Silodosin
  • Tadalafil
  • Tafamidis
  • Tamsulosin
  • Telmisartan
  • Tetrabenazine
  • Tetracaine
  • Thalidomide
  • Thiazide diuretics
  • Thiopental
  • Thiothixene
  • Tizanidine
  • Trandolapril
  • Trandolapril; Verapamil
  • Tranylcypromine
  • Trazodone
  • Treprostinil
  • Valsartan
  • Vardenafil
  • Verapamil
  • Yohimbine
  • Ziprasidone

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