Prednicarbate

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Prednicarbate Brand Name– Dermatop

What is Prednicarbate

Prednicarbate is a topical, low- to medium-potency, synthetic non-fluorinated and non-halogenated corticosteroid.

It is similar in potency to hydrocortisone. It is used to relieve the inflammatory and pruritic manifestations of mild to moderate corticosteroid-responsive dermatoses.

Prednicarbate has anti-inflammatory, antipruritic, and vasoconstrictive properties.

The cream may be used in pediatric patients 1 year of age and older, although the safety and efficacy of use for longer than 3 weeks has not been established.

Prednicarbate was initially approved by the FDA in 1991.

Indications

  1. alopecia
  2. atopic dermatitis
  3. contact dermatitis
  4. discoid lupus erythematosus
  5. eczema
  6. exfoliative dermatitis
  7. granuloma annulare
  8. keloids
  9. lichen planus
  10. lichen simplex
  11. lichen striatus
  12. necrobiosis lipoidica diabeticorum
  13. pemphigus
  14. pityriasis rosea
  15. polymorphous light eruption
  16. pompholyx
  17. prurigo
  18. pruritus
  19. psoriasis
  20. Rhus dermatitis
  21. sarcoidosis
  22. seborrheic dermatitis
  23. xerosis

Side Effects

  1. acneiform rash
  2. adrenocortical insufficiency
  3. cataracts
  4. contact dermatitis
  5. Cushing’s syndrome
  6. erythema
  7. folliculitis
  8. glycosuria
  9. growth inhibition
  10. headache
  11. hyperglycemia
  12. hypertension
  13. hypertrichosis
  14. hypothalamic-pituitary-adrenal (HPA) suppression
  15. impaired wound healing
  16. increased intracranial pressure
  17. infection
  18. maculopapular rash
  19. miliaria
  20. ocular hypertension
  21. papilledema
  22. pruritus
  23. pseudotumor cerebri
  24. purpura
  25. skin atrophy
  26. skin hypopigmentation
  27. skin irritation
  28. skin ulcer
  29. striae
  30. telangiectasia
  31. tolerance
  32. visual impairment
  33. withdrawal
  34. xerosis

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • acne rosacea
  • acne vulgaris
  • breast-feeding
  • children
  • corticosteroid hypersensitivity
  • Cushing’s syndrome
  • diabetes mellitus
  • fungal infection
  • geriatric
  • growth inhibition
  • herpes infection
  • hypothalamic-pituitary-adrenal (HPA) suppression
  • increased intracranial pressure
  • infants
  • infection
  • measles
  • neonates
  • occlusive dressing
  • ocular exposure
  • ophthalmic administration
  • perioral dermatitis
  • pregnancy
  • skin abrasion
  • skin atrophy
  • vaginal administration
  • varicella
  • viral infection

Interactions

  • Metyrapone

Metyrapone: (Major) Medications which affect pituitary or adrenocortical function, including all corticosteroid therapy, should be discontinued prior to and during testing with metyrapone. Patients taking inadvertent doses of corticosteroids on the test day may exhibit abnormally high basal plasma cortisol levels and a decreased response to the test. Although systemic absorption of topical corticosteroids is minimal, temporary discontinuation of these products should be considered if possible to reduce the potential for interference with the test results. 

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