Pralatrexate Brand Name– Folotyn
What is Pralatrexate
Pralatrexate is a dihydrofolate reductase inhibitor that is indicated for the treatment of adults with relapsed or refractory peripheral T-cell lymphoma.
All patients require vitamin B12 and folic acid supplementation starting prior to pralatrexate therapy.
Indications
- peripheral T-cell lymphoma (PTCL)
For the treatment of peripheral T-cell lymphoma (PTCL)
NOTE: Pralatrexate has been designated an orphan drug by the FDA for the treatment of T-cell lymphoma.
for the treatment of relapsed or refractory PTCL
Side Effects
- abdominal pain
- abdominal pain
- anemia
- anemia
- anorexia
- anorexia
- asthenia
- asthenia
- back pain
- back pain
- cardiac arrest
- constipation
- cough
- cough
- dehydration
- diarrhea
- diarrhea
- dyspnea
- dyspnea
- edema
- edema
- elevated hepatic enzymes
- elevated hepatic enzymes
- epistaxis
- fatigue
- fatigue
- hypokalemia
- hypokalemia
- infection
- infection
- leukopenia
- leukopenia
- nausea
- nausea
- neutropenia
- neutropenia
- night sweats
- pancytopenia
- pruritus
- pruritus
- rash
- sinus tachycardia
- skin ulcer
- stomatitis
- stomatitis
- thrombocytopenia
- thrombocytopenia
- toxic epidermal necrolysis
- tumor lysis syndrome (TLS)
- vomiting
- vomiting
Monitoring Parameters
- CBC with differential
- LFTs
- pregnancy testing
- serum creatinine/BUN
- serum electrolytes
- serum uric acid
Contraindications
- anemia
- breast-feeding
- contraception requirements
- geriatric
- hepatic disease
- male-mediated teratogenicity
- neutropenia
- oral ulceration
- pregnancy
- pregnancy testing
- renal disease
- renal impairment
- serious rash
- thrombocytopenia
- tumor lysis syndrome (TLS)
Interactions
- Abciximab
- Alpha interferons
- Alteplase
- Anagrelide
- Anticoagulants
- Antithrombin III
- Antithymocyte Globulin
- Apixaban
- Argatroban
- Aspirin, ASA; Dipyridamole
- Bacillus Calmette-Guerin Vaccine, BCG
- Betrixaban
- Bivalirudin
- Carbamazepine
- Cilostazol
- Clopidogrel
- Clozapine
- Colchicine; Probenecid
- Dabigatran
- Dalteparin
- Danaparoid
- Desirudin
- Dipyridamole
- Echinacea
- Edoxaban
- Enoxaparin
- Eptifibatide
- Febuxostat
- Fondaparinux
- Glucarpidase
- Heparin
- Influenza Virus Vaccine
- Intranasal Influenza Vaccine
- Lepirudin
- Live Vaccines
- Measles Virus; Mumps Virus; Rubella Virus; Varicella Virus Vaccine, Live
- Measles/Mumps/Rubella Vaccines, MMR
- Nonsteroidal antiinflammatory drugs
- Palifermin
- Penicillamine
- Pentosan
- Platelet Inhibitors
- Prasugrel
- Probenecid
- Reteplase, r-PA
- Rivaroxaban
- Rotavirus Vaccine
- Rubella Virus Vaccine Live
- Sapropterin
- Smallpox and Monkeypox Vaccine, Live, Nonreplicating
- Smallpox Vaccine, Vaccinia Vaccine
- Streptokinase
- Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
- Tenecteplase
- Thrombolytic Agents
- Ticagrelor
- Ticlopidine
- Tinzaparin
- Tirofiban
- Trimethoprim
- Tuberculin Purified Protein Derivative, PPD
- Typhoid Vaccine
- Urokinase
- Varicella-Zoster Virus Vaccine, Live
- Vorapaxar
- Warfarin
- Yellow Fever Vaccine, Live
