Povidone Iodine

Povidone Iodine Brand Names

Betadine | Betadine Prep | GRx Dyne | GRx Dyne Scrub | Povidex | Povidex Peri

What is Povidone Iodine

Povidone Iodine is a topical broad-spectrum germicidal agent. It is an iodophor which consists of iodine complexed with a solubilizing agent or carrier such as polyvinylpyrrolidone (povidone).

The spectrum of activity of povidone-iodine is the same as elemental iodine which includes bacteria, fungi, viruses, protozoa, and spores.

Just as with elemental iodine, resistance to povidone-iodine is usually not observed with most organisms.

Clinical applications for povidone-iodine include burn treatment adjunct, cleansing open wounds, operative wound infection antisepsis, and skin preparation prior to surgery.

Compared to elemental iodine, povidone-iodine, as well as other iodophors, causes less pain when applied to wounds and abrasions.

Povidone iodine was FDA approved in December 1986.

Indications

1. burns
2. Candida albicans
3. Gardnerella vaginalis
4. skin abrasion
5. surgical infection prophylaxis
6. Trichomonas vaginalis

Side Effects

1. anaphylactoid reactions
2. angioedema
3. cyanosis
4. diarrhea
5. erythema
6. hyperthyroidism
7. hypotension
8. hypothyroidism
9. metabolic acidosis
10. nausea
11. ocular irritation
12. renal failure (unspecified)
13. renal tubular necrosis
14. sinus tachycardia
15. skin irritation
16. urticaria
17. vomiting

Monitoring Parameters

• laboratory monitoring not necessary

Contraindications

• breast-feeding
• burns
• caesarean section
• children
• infants
• iodine hypersensitivity
• labor
• neonates
• obstetric delivery
• ocular exposure
• pregnancy
• renal impairment
• thyroid disease

Interactions

• Benzalkonium Chloride
• Bupivacaine
• Bupivacaine Liposomal
• Bupivacaine; Lidocaine
• Collagenase
• Fibrin Sealant, Human