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Phenylephrine and Promethazine Brand Names- Phen-Tuss AD | Prometh VC Plain
What is Phenylephrine and Promethazine
Phenylephrine and promethazine are used together in an oral liquid preparation to relieve upper respiratory symptoms, including nasal congestion, associated with allergy or the common cold.
Phenylephrine is a sympathomimetic amine that is a potent postsynaptic alpha-receptor agonist that i used as a decongestant.
Promethazine is a sedating antihistamine (H1-blocker) structurally related to the phenothiazines that dries the nasal and sinus passages. In addition to its antihistaminic action, it provides clinically useful sedative and antiemetic effects.
In November 2004, the FDA directed manufacturers of promethazine-containing products to include a boxed warning contraindicating use in children and infants less than 2 years of age due to an increased risk for fatal respiratory depression.
Caution should be exercised when administering phenylephrine; promethazine to pediatric patients 2 years of age and older.
Phenylephrine and promethazine was approved by the FDA in 1984.
Indications
- common cold
- nasal congestion
For the temporary relief of upper respiratory symptoms, including nasal congestion, associated with allergy or the common cold
Side Effects
- agranulocytosis
- akathisia
- angina
- anxiety
- aplastic anemia
- apnea
- blurred vision
- bradycardia
- cholestasis
- confusion
- constipation
- contact dermatitis
- corneal opacification
- dizziness
- drowsiness
- dystonic reaction
- dysuria
- eosinophilia
- fatigue
- fever
- hallucinations
- headache
- heart failure
- hemolytic anemia
- hepatitis
- hyperglycemia
- hypertension
- hyperthermia
- hypotension
- hypothermia
- ileus
- impaired cognition
- impotence (erectile dysfunction)
- insomnia
- intracranial bleeding
- jaundice
- leukopenia
- mydriasis
- myocardial infarction
- nausea
- neuroleptic malignant syndrome
- neutropenia
- pallor
- palpitations
- pancytopenia
- photosensitivity
- platelet dysfunction
- pseudoparkinsonism
- psychosis
- purpura
- rash
- respiratory depression
- restlessness
- retinopathy
- seizures
- skin hyperpigmentation
- tardive dyskinesia
- thrombocytopenia
- urinary retention
- ventricular tachycardia
- visual impairment
- vomiting
- weight gain
- xerophthalmia
- xerostomia
Monitoring Parameters
- blood pressure
- heart rate
- LFTs
Contraindications
- accidental exposure
- acute bronchospasm
- acute myocardial infarction
- agranulocytosis
- aneurysm
- angina
- arteriosclerosis
- asthma
- atrial fibrillation
- atrial flutter
- bladder obstruction
- bone marrow suppression
- breast-feeding
- bronchitis
- cardiac arrhythmias
- cardiac disease
- cardiomyopathy
- cerebrovascular disease
- children
- chronic obstructive pulmonary disease (COPD)
- closed-angle glaucoma
- contact lenses
- coronary artery disease
- dehydration
- diabetes mellitus
- driving or operating machinery
- emphysema
- geriatric
- GI disease
- GI obstruction
- head trauma
- heart failure
- hepatic disease
- hypertension
- hyperthyroidism
- ileus
- increased intracranial pressure
- increased intraocular pressure
- infants
- intracranial bleeding
- jaundice
- labor
- MAOI therapy
- myocardial infarction
- neonates
- obstetric delivery
- open-angle glaucoma
- organic brain syndrome
- peripheral vascular disease
- phenothiazine hypersensitivity
- pregnancy
- prostatic hypertrophy
- radiographic contrast administration
- renal disease
- renal failure
- renal impairment
- respiratory depression
- Reye’s syndrome
- seizure disorder
- seizures
- sleep apnea
- status asthmaticus
- stroke
- sulfite hypersensitivity
- sunlight (UV) exposure
- surgery
- tachycardia
- thyroid disease
- thyrotoxicosis
- tobacco smoking
- urethral stricture
- urinary retention
- ventricular fibrillation
- ventricular tachycardia
Interactions
- Abarelix
- Acarbose
- Acebutolol
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Diphenhydramine
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Pseudoephedrine
- Acetaminophen; Tramadol
- Acetohexamide
- Aclidinium; Formoterol
- Acrivastine; Pseudoephedrine
- Albiglutide
- Albuterol
- Albuterol; Ipratropium
- Alfentanil
- Alfuzosin
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Alogliptin
- Alogliptin; Metformin
- Alogliptin; Pioglitazone
- Alosetron
- Alpha-blockers
- Alpha-glucosidase Inhibitors
- Alprazolam
- Amantadine
- Ambrisentan
- Amifampridine
- Amikacin
- Amiloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Aminoglycosides
- Aminolevulinic Acid
- Amiodarone
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amobarbital
- Amoxapine
- Amoxicillin; Clarithromycin; Lansoprazole
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- Carbamazepine
- Carbetapentane; Chlorpheniramine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbetapentane; Pyrilamine
- Carbidopa; Levodopa
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Cardiac glycosides
- Cariprazine
- Carisoprodol
- Carteolol
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- Celecoxib
- Cenobamate
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- Ceritinib
- Cetirizine; Pseudoephedrine
- Cetrorelix
- Cevimeline
- Charcoal
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- Chlophedianol; Guaifenesin; Phenylephrine
- Chloral Hydrate
- Chlordiazepoxide
- Chlordiazepoxide; Clidinium
- Chloroquine
- Chlorothiazide
- Chlorpheniramine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Chlorpromazine
- Chlorpropamide
- Chlorthalidone
- Chlorthalidone; Clonidine
- Chlorzoxazone
- Ciclesonide
- Ciprofloxacin
- Cisapride
- Citalopram
- Clarithromycin
- Clemastine
- Clevidipine
- Clindamycin; Tretinoin
- Clobazam
- Clofazimine
- Clomipramine
- Clonazepam
- Clonidine
- Clorazepate
- Clozapine
- Cobicistat
- Cocaine
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Colchicine
- Colchicine; Probenecid
- COMT inhibitors
- Corticosteroids
- Cortisone
- Crizotinib
- Cyclobenzaprine
- Dantrolene
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- Dasatinib
- Deflazacort
- Degarelix
- Desipramine
- Desloratadine; Pseudoephedrine
- Desmopressin
- Deutetrabenazine
- Dexamethasone
- Dexchlorpheniramine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmedetomidine
- Dexmethylphenidate
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Dextromethorphan; Quinidine
- Diazepam
- Dicyclomine
- Diethylpropion
- Digitoxin
- Digoxin
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Dihydroergotamine
- Diltiazem
- Dimenhydrinate
- Dipeptidyl Peptidase-4 Inhibitors
- Diphenhydramine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Diphenhydramine; Phenylephrine
- Disopyramide
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- Donepezil
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- Dorzolamide; Timolol
- Doxazosin
- Doxepin
- Doxylamine
- Doxylamine; Pyridoxine
- Dronabinol
- Dronedarone
- Droperidol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Dulaglutide
- Dutasteride; Tamsulosin
- Dyphylline
- Dyphylline; Guaifenesin
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Eliglustat
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Empagliflozin
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Enalapril; Felodipine
- Enalapril; Hydrochlorothiazide, HCTZ
- Encorafenib
- Enflurane
- Entrectinib
- Epinephrine
- Epoprostenol
- Eprosartan; Hydrochlorothiazide, HCTZ
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- Ergotamine
- Eribulin
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- Ertugliflozin; Metformin
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- Erythromycin
- Erythromycin; Sulfisoxazole
- Escitalopram
- Esketamine
- Esmolol
- Estazolam
- Eszopiclone
- Ethacrynic Acid
- Ethanol
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
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- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Ethosuximide
- Ethotoin
- Exenatide
- Ezogabine
- Felbamate
- Felodipine
- Fenfluramine
- Fentanyl
- Fexofenadine; Pseudoephedrine
- Fingolimod
- Flavoxate
- Flecainide
- Flibanserin
- Fluconazole
- Flucytosine
- Fludrocortisone
- Flunisolide
- Fluocinolone; Hydroquinone; Tretinoin
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluphenazine
- Flurazepam
- Fluticasone
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Fluvoxamine
- food
- Formoterol
- Formoterol; Mometasone
- Foscarnet
- Fosinopril; Hydrochlorothiazide, HCTZ
- Fosphenytoin
- Fospropofol
- Fostemsavir
- Furosemide
- Gabapentin
- Galantamine
- Ganirelix
- Gemifloxacin
- Gemtuzumab Ozogamicin
- Gentamicin
- Gilteritinib
- Ginger, Zingiber officinale
- Glasdegib
- Glimepiride
- Glimepiride; Pioglitazone
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- Glipizide
- Glipizide; Metformin
- Glyburide
- Glyburide; Metformin
- Glycopyrrolate
- Glycopyrrolate; Formoterol
- Goserelin
- Granisetron
- Green Tea
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Phenylephrine
- Guaifenesin; Pseudoephedrine
- Guanabenz
- Guanidine
- Halobetasol; Tazarotene
- Halofantrine
- Halogenated Anesthetics
- Haloperidol
- Halothane
- Histrelin
- Homatropine; Hydrocodone
- Hydantoins
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ; Irbesartan
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- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydrocortisone
- Hydromorphone
- Hydroxychloroquine
- Hydroxyzine
- Hyoscyamine
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
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- Sufentanil
- Sulfonylureas
- Sunitinib
- Tacrolimus
- Tadalafil
- Tamoxifen
- Tamsulosin
- Tapentadol
- Tazarotene
- Telavancin
- Telithromycin
- Temazepam
- Teniposide
- Terazosin
- Terbutaline
- Tetrabenazine
- Thalidomide
- Theophylline, Aminophylline
- Thiazide diuretics
- Thiazolidinediones
- Thiopental
- Thioridazine
- Thiothixene
- Thyroid hormones
- Tiagabine
- Timolol
- tobacco
- Tobramycin
- Tolazamide
- Tolbutamide
- Tolterodine
- Topiramate
- Toremifene
- Torsemide
- Tramadol
- Trandolapril; Verapamil
- Tranylcypromine
- Trazodone
- Treprostinil
- Tretinoin, ATRA
- Triamcinolone
- Triamterene
- Triazolam
- Triclabendazole
- Tricyclic antidepressants
- Trifluoperazine
- Trihexyphenidyl
- Trimethobenzamide
- Trimipramine
- Triprolidine
- Triptorelin
- Trospium
- Umeclidinium; Vilanterol
- Valproic Acid, Divalproex Sodium
- Vandetanib
- Vardenafil
- Vasodilators
- Vemurafenib
- Venlafaxine
- Verapamil
- Verteporfin
- Vigabatrin
- Voriconazole
- Vorinostat
- Yohimbine
- Zaleplon
- Ziconotide
- Ziprasidone
- Zolpidem
- Zonisamide