Phendimetrazine

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Phendimetrazine Brand Names

Bock-Arate | Bontril PDM | Bontril SR | Melfiat 105 Unicelles | Prelu-2 | Rapdone | Stabec-1

What is Phendimetrazine

Phendimetrazine is an oral, centrally-acting stimulant and sympathomimetic amine.

It is used as an adjunct to lifestyle modifications for the short-term treatment (i.e., a few weeks) of exogenous obesity. The pharmacologic effects of phendimetrazine are similar to amphetamines.

Similar to amphetamines, phendimetrazine can induce or exacerbate psychiatric symptoms (e.g., mania or psychosis), and is contraindicated in patients with a history of substance abuse due to abuse and addiction potential.

According to the American Association of Clinical Endocrinologists and American College of Endocrinology (AACE/ACE) Obesity Clinical Practice Guidelines, short-term pharmacotherapy, such as with phendimetrazine, has not been shown to produce longer-term health benefits in obese and overweight patients and cannot be generally recommended.

Phendimetrazine should not be used for long-term weight management; tolerance to the anorectic effect of stimulants has been demonstrated.

Phendimetrazine was approved by the FDA in 1961.

Indications

  • obesity

For the short-term (i.e., a few weeks) treatment of exogenous obesity

Side Effects

  1. abdominal pain
  2. agitation
  3. angina
  4. blurred vision
  5. cardiac valvulopathy
  6. chest pain (unspecified)
  7. constipation
  8. depression
  9. diarrhea
  10. dizziness
  11. dyskinesia
  12. dysphoria
  13. dyspnea
  14. dysuria
  15. EEG changes
  16. euphoria
  17. fatigue
  18. flushing
  19. headache
  20. hyperhidrosis
  21. hypertension
  22. impotence (erectile dysfunction)
  23. increased urinary frequency
  24. insomnia
  25. irritability
  26. libido decrease
  27. libido increase
  28. mydriasis
  29. nausea
  30. ocular irritation
  31. palpitations
  32. peripheral edema
  33. psychological dependence
  34. psychosis
  35. pulmonary hypertension
  36. restlessness
  37. sinus tachycardia
  38. syncope
  39. tolerance
  40. tremor
  41. vomiting
  42. withdrawal
  43. xerostomia

Monitoring Parameters

  • ECG

Contraindications

  • abrupt discontinuation
  • alcoholism
  • anorexia nervosa
  • anxiety
  • breast-feeding
  • cardiac arrhythmias
  • cardiac disease
  • children
  • coronary artery disease
  • depression
  • diabetes mellitus
  • driving or operating machinery
  • geriatric
  • glaucoma
  • heart failure
  • hypertension
  • hyperthyroidism
  • infants
  • long QT syndrome
  • mania
  • MAOI therapy
  • pregnancy
  • psychosis
  • pulmonary hypertension
  • renal impairment
  • stroke
  • substance abuse
  • suicidal ideation
  • surgery
  • thyroid disease
  • valvular heart disease

Interactions

  • Acarbose
  • Acebutolol
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Aclidinium; Formoterol
  • Albiglutide
  • Albuterol
  • Albuterol; Ipratropium
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Alogliptin; Pioglitazone
  • Alpha-blockers
  • Alpha-glucosidase Inhibitors
  • Ambrisentan
  • Amifampridine
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Amitriptyline
  • Amitriptyline; Chlordiazepoxide
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amoxapine
  • Arformoterol
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Atenolol
  • Atenolol; Chlorthalidone
  • Atomoxetine
  • Azilsartan; Chlorthalidone
  • Benazepril; Hydrochlorothiazide, HCTZ
  • Bendroflumethiazide; Nadolol
  • Beta-blockers
  • Betaxolol
  • Bethanechol
  • Bisoprolol
  • Bisoprolol; Hydrochlorothiazide, HCTZ
  • Bosentan
  • Bretylium
  • Brimonidine; Timolol
  • Bromocriptine
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Dextromethorphan; Phenylephrine
  • Budesonide; Formoterol
  • Bupropion
  • Bupropion; Naltrexone
  • Caffeine
  • Caffeine; Ergotamine
  • Canagliflozin
  • Canagliflozin; Metformin
  • Candesartan; Hydrochlorothiazide, HCTZ
  • Captopril; Hydrochlorothiazide, HCTZ
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Phenylephrine
  • Cardiac glycosides
  • Carteolol
  • Carvedilol
  • Chlophedianol; Guaifenesin; Phenylephrine
  • Chlorothiazide
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Phenylephrine
  • Chlorthalidone
  • Chlorthalidone; Clonidine
  • Clomipramine
  • Clonidine
  • Cocaine
  • Codeine; Phenylephrine; Promethazine
  • Colchicine
  • Colchicine; Probenecid
  • Dapagliflozin
  • Dapagliflozin; Metformin
  • Dapagliflozin; Saxagliptin
  • Desipramine
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Guaifenesin; Phenylephrine
  • Digitoxin
  • Digoxin
  • Dipeptidyl Peptidase-4 Inhibitors
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Phenylephrine
  • Dopamine
  • Dorzolamide; Timolol
  • Doxazosin
  • Doxepin
  • Dronabinol
  • Droxidopa
  • Dulaglutide
  • Dyphylline
  • Dyphylline; Guaifenesin
  • Empagliflozin
  • Empagliflozin; Linagliptin
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Ephedrine
  • Epoprostenol
  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Ertugliflozin
  • Ertugliflozin; Metformin
  • Ertugliflozin; Sitagliptin
  • Esketamine
  • Esmolol
  • Exenatide
  • Fluticasone; Salmeterol
  • Fluticasone; Umeclidinium; Vilanterol
  • Fluticasone; Vilanterol
  • Formoterol
  • Formoterol; Mometasone
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Glimepiride; Pioglitazone
  • Glimepiride; Rosiglitazone
  • Glycopyrrolate; Formoterol
  • Green Tea
  • Guaifenesin; Phenylephrine
  • Guanabenz
  • Halothane
  • Hydralazine; Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ; Irbesartan
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Hydrocodone; Phenylephrine
  • Iloprost
  • Imipramine
  • Incretin Mimetics
  • Indacaterol
  • Indacaterol; Glycopyrrolate
  • Indapamide
  • Insulin Degludec; Liraglutide
  • Insulin Glargine; Lixisenatide
  • Insulins
  • Iobenguane I 131
  • Iohexol
  • Iopamidol
  • Iopromide
  • Ioversol
  • Isocarboxazid
  • Isoflurane
  • Isosulfan Blue
  • Labetalol
  • Levalbuterol
  • Levobetaxolol
  • Levobunolol
  • Levothyroxine
  • Levothyroxine; Liothyronine (Porcine)
  • Levothyroxine; Liothyronine (Synthetic)
  • Linezolid
  • Liothyronine
  • Liraglutide
  • Lithium
  • Lixisenatide
  • Lorcaserin
  • Macitentan
  • Maprotiline
  • Mecamylamine
  • Meglitinides
  • Metaproterenol
  • Metformin; Pioglitazone
  • Metformin; Rosiglitazone
  • Methyclothiazide
  • Methyldopa
  • Metolazone
  • Metoprolol
  • Midodrine
  • Miglitol
  • Monoamine oxidase inhibitors
  • Nabilone
  • Nadolol
  • Nebivolol
  • Nebivolol; Valsartan
  • Nitrates
  • Non-Ionic Contrast Media
  • Norepinephrine
  • Nortriptyline
  • Ozanimod
  • Penbutolol
  • Perphenazine; Amitriptyline
  • Phenelzine
  • Phenoxybenzamine
  • Phentermine
  • Phentermine; Topiramate
  • Phentolamine
  • Phenylephrine
  • Phenylephrine; Promethazine
  • Pindolol
  • Pioglitazone
  • Pirbuterol
  • Pramlintide
  • Prazosin
  • Procarbazine
  • Propranolol
  • Protriptyline
  • Rasagiline
  • Reserpine
  • Riociguat
  • Rosiglitazone
  • Safinamide
  • Salmeterol
  • Selegiline
  • Selexipag
  • Semaglutide
  • Sevoflurane
  • SGLT2 Inhibitors
  • Sibutramine
  • Sodium Oxybate
  • Sotalol
  • St. John’s Wort, Hypericum perforatum
  • Sulfonylureas
  • Terazosin
  • Terbutaline
  • Theophylline, Aminophylline
  • Thiazide diuretics
  • Thiazolidinediones
  • Thyroid hormones
  • Timolol
  • Tranylcypromine
  • Treprostinil
  • Tricyclic antidepressants
  • Trimipramine
  • Umeclidinium; Vilanterol
  • Vasodilators
  • Vasopressors
  • Yohimbine

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