Pergolide Brand Name– Permax
What is Pergolide
NOTE: This drug is discontinued in the U.S.
Pergolide was an oral, semisynthetic ergot alkaloid derivative used in the management of Parkinson’s disease.
Pergolide was similar in action to other drugs in this class such as bromocriptine, however, pergolide had 10 to 1,000 times the potency of bromocriptine on a milligram basis and may be effective in patients who have become tolerant to bromocriptine.
Despite its effectiveness, pergolide has been linked to an increased risk of valvular regurgitation.
Development of valvular heart disease in association with pergolide use was first described in 2002, followed by the addition of a black box warning to the product labeling relating to valvulopathy in 2006.
Subsequent study results substantiated an increased risk of valvular regurgitation. Due to growing safety concerns, the drug was withdrawn from commercial marketing.
Indications
- Parkinson’s disease
- restless legs syndrome (RLS)
For use as an adjunct to levodopa/carbidopa in the treatment of Parkinson’s disease
Side Effects
- abdominal pain
- akathisia
- anxiety
- back pain
- cardiac valvulopathy
- constipation
- diarrhea
- diplopia
- dizziness
- drowsiness
- dyspepsia
- dyspnea
- dystonic reaction
- fever
- hallucinations
- hypertension
- insomnia
- intracranial bleeding
- involuntary movements
- myalgia
- myocardial infarction
- nausea
- orthostatic hypotension
- palpitations
- pericardial effusion
- pericarditis
- pleural effusion
- psychosis
- pulmonary fibrosis
- retroperitoneal fibrosis
- rhinitis
- sudden sleep onset
- syncope
- vomiting
- weakness
- weight gain
- weight loss
- withdrawal
- xerostomia
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- abrupt discontinuation
- breast-feeding
- driving or operating machinery
- ergot alkaloid hypersensitivity
- geriatric
- orthostatic hypotension
- pericardial effusion
- pericarditis
- pleural effusion
- pregnancy
- pulmonary fibrosis
- retroperitoneal fibrosis
- valvular heart disease
Interactions
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Pseudoephedrine
- Acrivastine; Pseudoephedrine
- Almotriptan
- Amphetamine; Dextroamphetamine Salts
- Aprepitant, Fosaprepitant
- Aripiprazole
- Asenapine
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- atypical antipsychotic
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Benzphetamine
- Boceprevir
- Brexpiprazole
- Bromocriptine
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Bupivacaine
- Bupivacaine Liposomal
- Bupivacaine; Lidocaine
- Butyrophenone
- Cabergoline
- Carbetapentane; Pseudoephedrine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Pseudoephedrine
- Cariprazine
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chloroprocaine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Pseudoephedrine
- Chlorpromazine
- Citalopram
- Clozapine
- Cocaine
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Danazol
- Delavirdine
- Desloratadine; Pseudoephedrine
- Desvenlafaxine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmethylphenidate
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Dextromethorphan; Promethazine
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Dobutamine
- Donepezil; Memantine
- Duloxetine
- Elbasvir; Grazoprevir
- Eletriptan
- Escitalopram
- Fexofenadine; Pseudoephedrine
- Fluconazole
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluphenazine
- Fluvoxamine
- Frovatriptan
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Pseudoephedrine
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibuprofen; Pseudoephedrine
- Iloperidone
- Imatinib
- Itraconazole
- Ketoconazole
- Letermovir
- Levomilnacipran
- Lidocaine; Prilocaine
- Linezolid
- Lisdexamfetamine
- Loratadine; Pseudoephedrine
- Lorcaserin
- Loxapine
- Lumateperone
- Lurasidone
- Memantine
- Meperidine; Promethazine
- Mepivacaine
- Mepivacaine; Levonordefrin
- Mesoridazine
- Methamphetamine
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methylene Blue
- Methylphenidate
- Metoclopramide
- Miconazole
- Milnacipran
- Mirtazapine
- Molindone
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Naratriptan
- Nicotine
- Nilotinib
- Nitrates
- Nitroprusside
- Olanzapine
- Paliperidone
- Paroxetine
- Perphenazine
- Perphenazine; Amitriptyline
- Phenothiazines
- Phentermine
- Phentermine; Topiramate
- Phenylephrine; Promethazine
- Pimozide
- Posaconazole
- Prilocaine
- Prilocaine; Epinephrine
- Procaine
- Prochlorperazine
- Promethazine
- Protease inhibitors
- Pseudoephedrine
- Quetiapine
- Quinine
- Ranolazine
- Risperidone
- Rizatriptan
- Rufinamide
- Serotonin norepinephrine reuptake inhibitors
- Serotonin-Receptor Agonists
- Sertraline
- Sibutramine
- Sumatriptan
- Tedizolid
- Telaprevir
- Telithromycin
- Thiethylperazine
- Thioridazine
- Thiothixene
- Trifluoperazine
- Vasopressors
- Venlafaxine
- Vilazodone
- Voriconazole
- Vortioxetine
- Ziprasidone
- Zolmitriptan
