Penicillin G Benzathine Penicillin G Procaine Brand Name– Bicillin C R
What is Penicillin G Benzathine Penicillin G Procaine
Penicillin G Benzathine Penicillin G Procaine is a combination of two long-acting forms of Penicillin G.
Penicillin G Benzathine Penicillin G Procaine is for intramuscular use only.
After injection of this combination product, a depot forms in the tissue, from which the two forms of penicillin are hydrolyzed at the intramuscular injection site to penicillin G, and then slowly released into the blood stream over several days.
This provides lower, though prolonged, serum concentrations of penicillin compared to aqueous penicillin G.
These characteristics can increase patient compliance, but limit the therapeutic uses.
Penicillin G Benzathine Penicillin G Procaine is approved for use in moderately severe streptococcal and pneumococcal infections, and should not be used for the treatment of sexually transmitted infections such as syphilis.
Penicillins were initially discovered in 1928 and first used clinically in 1941.
Penicillin G was approved by the FDA in 1943.
Indications
- Actinomyces israelii
- Bacillus anthracis
- Clostridium sp.
- Corynebacterium diphtheriae
- erysipelas
- Leptospira sp.
- Listeria monocytogenes
- Neisseria gonorrhoeae
- otitis media
- pneumonia
- scarlet fever
- skin and skin structure infections
- Staphylococcus sp.
- Streptobacillus moniliformis
- Streptococcus agalactiae (group B streptococci)
- Streptococcus bovis
- Streptococcus dysgalactiae
- Streptococcus pneumoniae
- Streptococcus pyogenes (group A beta-hemolytic streptococci)
- Streptococcus sp.
- Treponema pallidum
- upper respiratory tract infections
- Viridans streptococci
Side Effects
- acute generalized exanthematous pustulosis (AGEP)
- agitation
- anaphylactic shock
- anaphylactoid reactions
- angioedema
- anxiety
- apnea
- asthenia
- bleeding
- blurred vision
- bowel necrosis
- cardiac arrest
- chills
- coma
- confusion
- cyanosis
- diaphoresis
- diarrhea
- dizziness
- drowsiness
- dyspnea
- edema
- elevated hepatic enzymes
- eosinophilia
- euphoria
- exfoliative dermatitis
- fatigue
- fever
- hallucinations
- headache
- hematuria
- hemolytic anemia
- hypotension
- hypoxia
- impotence (erectile dysfunction)
- injection site reaction
- laryngeal edema
- leukopenia
- lymphadenopathy
- maculopapular rash
- methemoglobinemia
- myelitis
- myoglobinuria
- nausea
- pallor
- palpitations
- peripheral vasodilation
- priapism
- proteinuria
- pruritus
- pseudomembranous colitis
- psychosis
- pulmonary embolism
- pulmonary hypertension
- rash
- renal failure (unspecified)
- rhabdomyolysis
- seizures
- serum sickness
- sinus tachycardia
- skin atrophy
- skin ulcer
- Stevens-Johnson syndrome
- superinfection
- syncope
- thrombocytopenia
- tinnitus
- tissue necrosis
- tongue discoloration
- toxic epidermal necrolysis
- urticaria
- vasculitis
- vomiting
Monitoring Parameters
- serum creatinine/BUN
Contraindications
- asthma
- breast-feeding
- carbapenem hypersensitivity
- cardiac disease
- cephalosporin hypersensitivity
- colitis
- diarrhea
- ester local anesthetic hypersensitivity
- G6PD deficiency
- geriatric
- GI disease
- infants
- inflammatory bowel disease
- intravenous administration
- methemoglobinemia
- neonates
- penicillin hypersensitivity
- pregnancy
- pseudomembranous colitis
- pulmonary disease
- renal failure
- renal impairment
- syphilis
- ulcerative colitis
- viral infection
Interactions
- Acetaminophen
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Diphenhydramine
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Pseudoephedrine
- Acetaminophen; Tramadol
- Aminosalicylate sodium, Aminosalicylic acid
- Amyl Nitrite
- Articaine; Epinephrine
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Benzhydrocodone; Acetaminophen
- Benzocaine
- Benzocaine; Butamben; Tetracaine
- Bupivacaine
- Bupivacaine Liposomal
- Bupivacaine; Lidocaine
- Chloroquine
- Cholestyramine
- Choline Salicylate; Magnesium Salicylate
- Colchicine; Probenecid
- Colestipol
- Cyclophosphamide
- Dapsone
- Dichlorphenamide
- Dienogest; Estradiol valerate
- Digoxin
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Elagolix; Estradiol; Norethindrone acetate
- Erythromycin; Sulfisoxazole
- Estradiol; Levonorgestrel
- Estradiol; Norethindrone
- Estradiol; Norgestimate
- Ethacrynic Acid
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Flutamide
- Fosphenytoin
- Furosemide
- Hydralazine; Isosorbide Dinitrate, ISDN
- Hydroxyurea
- Ifosfamide
- Indomethacin
- Isosorbide Dinitrate, ISDN
- Isosorbide Mononitrate
- Leflunomide
- Leuprolide; Norethindrone
- Levonorgestrel
- Lidocaine
- Lidocaine; Prilocaine
- Magnesium Salicylate
- Mepivacaine
- Mepivacaine; Levonordefrin
- Mestranol; Norethindrone
- Methotrexate
- Metoclopramide
- Nitisinone
- Nitrates
- Nitrofurantoin
- Nitroglycerin
- Norethindrone
- Norgestrel
- Oral Contraceptives
- Phenobarbital
- Phenytoin
- Prilocaine
- Prilocaine; Epinephrine
- Primaquine
- Primidone
- Probenecid
- Pyrimethamine; Sulfadoxine
- Quinine
- Rasburicase
- Ropivacaine
- Salsalate
- Segesterone Acetate; Ethinyl Estradiol
- Sodium Benzoate; Sodium Phenylacetate
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Sulfadiazine
- Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
- Sulfasalazine
- Sulfisoxazole
- Sulfonamides
- Teriflunomide
- Tetracaine
- Tetracyclines
- Typhoid Vaccine
- Valproic Acid, Divalproex Sodium
- Warfarin
