Pegaspargase Brand Name– Oncaspar
What is Pegaspargase
Pegaspargase is an asparagine specific enzyme that is indicated for the first-line treatment of acute lymphoblastic leukemia (ALL) in adults and pediatric patients and ALL in adults and pediatric patients who experienced hypersensitivity to native forms of L-asparaginase.
It is used in combination with multi-agent chemotherapy.
Use of pegaspargase is contraindicated in patients with severe hepatic impairment, a history of pancreatitis, or who have had a serious thrombosis or hemorrhagic event related to prior L-asparaginase therapy.
Indications
- acute lymphocytic leukemia (ALL)
For the treatment of acute lymphocytic leukemia (ALL)
NOTE: The FDA has designated pegaspargase as an orphan drug for the treatment of ALL.
for the treatment of newly diagnosed ALL, in combination with multi-agent chemotherapy
Side Effects
- anaphylactic shock
- anaphylactoid reactions
- antibody formation
- bleeding
- bronchospasm
- coagulopathy
- elevated hepatic enzymes
- encephalopathy
- erythema
- hyperammonemia
- hyperamylasemia
- hyperbilirubinemia
- hypercholesterolemia
- hyperglycemia
- hypertriglyceridemia
- hypoalbuminemia
- hypotension
- infusion-related reactions
- intracranial bleeding
- laryngeal edema
- neutropenia
- pancreatitis
- prolonged bleeding time
- rash
- thromboembolism
- thrombosis
- urticaria
Monitoring Parameters
- blood glucose
- LFTs
- pregnancy testing
Contraindications
- bleeding
- breast-feeding
- contraception requirements
- hepatic disease
- hyperglycemia
- infusion-related reactions
- pancreatitis
- pregnancy
- pregnancy testing
- reproductive risk
- thromboembolism
- thrombosis
Interactions
- Abciximab
- Alpha interferons
- Alteplase
- Amlodipine; Celecoxib
- Anagrelide
- Anticoagulants
- Antithrombin III
- Apixaban
- Argatroban
- Aspirin, ASA; Dipyridamole
- Azelastine; Fluticasone
- Beclomethasone
- Betamethasone
- Betrixaban
- Bivalirudin
- Budesonide
- Budesonide; Formoterol
- Carbamazepine
- Celecoxib
- Ciclesonide
- Cilostazol
- Clopidogrel
- Clozapine
- Corticosteroids
- Cortisone
- Cytarabine, ARA-C
- Dabigatran
- Dalteparin
- Danaparoid
- Deflazacort
- Desirudin
- Dexamethasone
- Diclofenac
- Diclofenac; Misoprostol
- Dienogest; Estradiol valerate
- Diflunisal
- Digoxin
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Dipyridamole
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Echinacea
- Edoxaban
- Elagolix; Estradiol; Norethindrone acetate
- Enoxaparin
- Eptifibatide
- Esomeprazole; Naproxen
- Estradiol; Levonorgestrel
- Estradiol; Norethindrone
- Estradiol; Norgestimate
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Etodolac
- Etonogestrel
- Famotidine; Ibuprofen
- Febuxostat
- Fenoprofen
- Filgrastim, G-CSF
- Fludrocortisone
- Flunisolide
- Flurbiprofen
- Fluticasone
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Fondaparinux
- Formoterol; Mometasone
- Heparin
- Hydrocodone; Ibuprofen
- Hydrocortisone
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Indomethacin
- Interferon Alfa-2a
- Interferon Alfa-2b
- Interferon Alfa-2b; Ribavirin
- Interferon Alfa-n3
- Interferon Alfacon-1
- Ketoprofen
- Ketorolac
- Lansoprazole; Naproxen
- Lepirudin
- Leuprolide; Norethindrone
- Levonorgestrel
- Meclofenamate Sodium
- Mefenamic Acid
- Meloxicam
- Mestranol; Norethindrone
- Methotrexate
- Methylprednisolone
- Mometasone
- Nabumetone
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Non-oral combination contraceptives
- Nonsteroidal antiinflammatory drugs
- Norethindrone
- Norgestrel
- Oral Contraceptives
- Oxaprozin
- Palifermin
- Pegfilgrastim
- Peginterferon Alfa-2a
- Peginterferon Alfa-2b
- Penicillamine
- Pentosan
- Piroxicam
- Platelet Inhibitors
- Prasugrel
- Prednisolone
- Prednisone
- Reteplase, r-PA
- Rivaroxaban
- Rofecoxib
- Segesterone Acetate; Ethinyl Estradiol
- Streptokinase
- Sulindac
- Tbo-Filgrastim
- Tenecteplase
- Thrombolytic Agents
- Ticagrelor
- Ticlopidine
- Tinzaparin
- Tirofiban
- Tolmetin
- Triamcinolone
- Tuberculin Purified Protein Derivative, PPD
- Urokinase
- Valdecoxib
- Vincristine
- Vincristine Liposomal
- Vorapaxar
- Warfarin
- Zonisamide