Palbociclib

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Palbociclib Brand Name– Ibrance

What is Palbociclib

Palbociclib is an oral, selective inhibitor of cyclin-dependent kinases (CDKs) 4 and 6, which are both involved in tumor cell progression during phase G1 to phase S in the cell cycle.

By inhibiting CDK 4 and 6, palbociclib prevents the deactivation of the tumor suppressor protein known as retinoblastoma susceptibility gene protein, and interferes with tumor cell progression.

Neutropenia is the most common adverse reaction; monitor complete blood counts as an interruption of therapy, dose reduction, or discontinuation of therapy may be necessary.

Indications

  • breast cancer

For the treatment of breast cancer

for the treatment of hormone receptor (HR)-positive, HER2-negative advanced breast cancer, in combination with an aromatase inhibitor as initial endocrine-based therapy

Side Effects

  1. acneiform rash
  2. alopecia
  3. anemia
  4. anemia
  5. anorexia
  6. anorexia
  7. asthenia
  8. asthenia
  9. blurred vision
  10. cheilitis
  11. conjunctivitis
  12. constipation
  13. cystitis
  14. diarrhea
  15. diarrhea
  16. dysgeusia
  17. epistaxis
  18. erythema
  19. fatigue
  20. fatigue
  21. fever
  22. glossitis
  23. headache
  24. headache
  25. infection
  26. infection
  27. influenza
  28. interstitial lung disease
  29. lacrimation
  30. laryngitis
  31. leukopenia
  32. leukopenia
  33. lymphopenia
  34. lymphopenia
  35. maculopapular rash
  36. nausea
  37. nausea
  38. neutropenia
  39. neutropenia
  40. oral ulceration
  41. peripheral neuropathy
  42. pharyngitis
  43. pneumonitis
  44. pruritus
  45. pulmonary embolism
  46. rash
  47. rash
  48. rhinitis
  49. sinusitis
  50. stomatitis
  51. stomatitis
  52. thrombocytopenia
  53. thrombocytopenia
  54. thromboembolism
  55. vomiting
  56. vomiting
  57. weakness
  58. weakness
  59. xerophthalmia
  60. xerosis

Monitoring Parameters

  • CBC with differential
  • LFTs
  • pregnancy testing
  • serum creatinine/BUN

Contraindications

  • breast-feeding
  • chronic lung disease (CLD)
  • contraception requirements
  • fungal infection
  • infection
  • infertility
  • neutropenia
  • pneumonitis
  • pregnancy
  • pregnancy testing
  • reproductive risk
  • testicular failure
  • viral infection

Interactions

  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Codeine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Tramadol
  • Alfentanil
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Apalutamide
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Oxycodone
  • Atazanavir
  • Atazanavir; Cobicistat
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Benzhydrocodone; Acetaminophen
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Budesonide
  • Budesonide; Formoterol
  • Bupivacaine; Lidocaine
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Buspirone
  • Caffeine; Ergotamine
  • Carbamazepine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Ceritinib
  • Cevimeline
  • Chloramphenicol
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Cisapride
  • Clarithromycin
  • Clozapine
  • Cobicistat
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Colchicine
  • Colchicine; Probenecid
  • Conivaptan
  • Cyclosporine
  • Darunavir
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Delavirdine
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Dihydroergotamine
  • Diltiazem
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Disopyramide
  • Dofetilide
  • Doxorubicin
  • Dronabinol
  • Efavirenz
  • Efavirenz; Emtricitabine; Tenofovir
  • Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
  • Eliglustat
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Enalapril; Felodipine
  • Enzalutamide
  • Ergotamine
  • Ethosuximide
  • Felodipine
  • Fentanyl
  • Flibanserin
  • Fosamprenavir
  • Fosphenytoin
  • grapefruit juice
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Haloperidol
  • Homatropine; Hydrocodone
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Ibuprofen; Oxycodone
  • Idelalisib
  • Indinavir
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Isradipine
  • Itraconazole
  • Ixabepilone
  • Ketoconazole
  • Lemborexant
  • Letermovir
  • Lidocaine
  • Lidocaine; Prilocaine
  • Lomitapide
  • Lopinavir; Ritonavir
  • Lumacaftor; Ivacaftor
  • Mephobarbital
  • Methadone
  • Midazolam
  • Mifepristone
  • Mitotane
  • Nefazodone
  • Nelfinavir
  • Nimodipine
  • Nisoldipine
  • Ombitasvir; Paritaprevir; Ritonavir
  • Oxycodone
  • Phenobarbital
  • Phenytoin
  • Pimozide
  • Posaconazole
  • Primidone
  • Ribociclib
  • Ribociclib; Letrozole
  • Rifampin
  • Ritonavir
  • Saquinavir
  • St. John’s Wort, Hypericum perforatum
  • Sufentanil
  • Tacrolimus
  • Telithromycin
  • Tipranavir
  • Tramadol
  • Triazolam
  • Tucatinib
  • Ubrogepant
  • Vinorelbine
  • Voriconazole
  • Zolpidem

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