Palbociclib Brand Name– Ibrance
What is Palbociclib
Palbociclib is an oral, selective inhibitor of cyclin-dependent kinases (CDKs) 4 and 6, which are both involved in tumor cell progression during phase G1 to phase S in the cell cycle.
By inhibiting CDK 4 and 6, palbociclib prevents the deactivation of the tumor suppressor protein known as retinoblastoma susceptibility gene protein, and interferes with tumor cell progression.
Neutropenia is the most common adverse reaction; monitor complete blood counts as an interruption of therapy, dose reduction, or discontinuation of therapy may be necessary.
Indications
- breast cancer
For the treatment of breast cancer
for the treatment of hormone receptor (HR)-positive, HER2-negative advanced breast cancer, in combination with an aromatase inhibitor as initial endocrine-based therapy
Side Effects
- acneiform rash
- alopecia
- anemia
- anemia
- anorexia
- anorexia
- asthenia
- asthenia
- blurred vision
- cheilitis
- conjunctivitis
- constipation
- cystitis
- diarrhea
- diarrhea
- dysgeusia
- epistaxis
- erythema
- fatigue
- fatigue
- fever
- glossitis
- headache
- headache
- infection
- infection
- influenza
- interstitial lung disease
- lacrimation
- laryngitis
- leukopenia
- leukopenia
- lymphopenia
- lymphopenia
- maculopapular rash
- nausea
- nausea
- neutropenia
- neutropenia
- oral ulceration
- peripheral neuropathy
- pharyngitis
- pneumonitis
- pruritus
- pulmonary embolism
- rash
- rash
- rhinitis
- sinusitis
- stomatitis
- stomatitis
- thrombocytopenia
- thrombocytopenia
- thromboembolism
- vomiting
- vomiting
- weakness
- weakness
- xerophthalmia
- xerosis
Monitoring Parameters
- CBC with differential
- LFTs
- pregnancy testing
- serum creatinine/BUN
Contraindications
- breast-feeding
- chronic lung disease (CLD)
- contraception requirements
- fungal infection
- infection
- infertility
- neutropenia
- pneumonitis
- pregnancy
- pregnancy testing
- reproductive risk
- testicular failure
- viral infection
Interactions
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Codeine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Tramadol
- Alfentanil
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Apalutamide
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Oxycodone
- Atazanavir
- Atazanavir; Cobicistat
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Benzhydrocodone; Acetaminophen
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Budesonide
- Budesonide; Formoterol
- Bupivacaine; Lidocaine
- Buprenorphine
- Buprenorphine; Naloxone
- Buspirone
- Caffeine; Ergotamine
- Carbamazepine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Ceritinib
- Cevimeline
- Chloramphenicol
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Cisapride
- Clarithromycin
- Clozapine
- Cobicistat
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Colchicine
- Colchicine; Probenecid
- Conivaptan
- Cyclosporine
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Delavirdine
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Dihydroergotamine
- Diltiazem
- Diphenhydramine; Hydrocodone; Phenylephrine
- Disopyramide
- Dofetilide
- Doxorubicin
- Dronabinol
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Eliglustat
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Enalapril; Felodipine
- Enzalutamide
- Ergotamine
- Ethosuximide
- Felodipine
- Fentanyl
- Flibanserin
- Fosamprenavir
- Fosphenytoin
- grapefruit juice
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Haloperidol
- Homatropine; Hydrocodone
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Ibuprofen; Oxycodone
- Idelalisib
- Indinavir
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Isradipine
- Itraconazole
- Ixabepilone
- Ketoconazole
- Lemborexant
- Letermovir
- Lidocaine
- Lidocaine; Prilocaine
- Lomitapide
- Lopinavir; Ritonavir
- Lumacaftor; Ivacaftor
- Mephobarbital
- Methadone
- Midazolam
- Mifepristone
- Mitotane
- Nefazodone
- Nelfinavir
- Nimodipine
- Nisoldipine
- Ombitasvir; Paritaprevir; Ritonavir
- Oxycodone
- Phenobarbital
- Phenytoin
- Pimozide
- Posaconazole
- Primidone
- Ribociclib
- Ribociclib; Letrozole
- Rifampin
- Ritonavir
- Saquinavir
- St. John’s Wort, Hypericum perforatum
- Sufentanil
- Tacrolimus
- Telithromycin
- Tipranavir
- Tramadol
- Triazolam
- Tucatinib
- Ubrogepant
- Vinorelbine
- Voriconazole
- Zolpidem