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Oxycodone Brand Names
Dazidox | Endocodone | ETH-Oxydose | Oxaydo | OXECTA
What is Oxycodone
Oxycodone is an oral semisynthetic opioid agonist derived from the opioid alkaloid, thebaine, and is similar to other phenanthrene derivatives, such as hydrocodone and morphine.
Oxycodone is approved for the treatment of moderate to severe pain.
Oxycodone has been reported to be as effective as morphine in relieving pain when given in equianalgesic doses, but oxycodone causes less nausea, vomiting, and hallucinations.
Oxycodone may have an improved toxicity profile in patients with impaired renal or hepatic function as compared to other opioid agonists
Indications
- diabetic neuropathy
- severe pain
Side Effects
- abdominal pain
- adrenocortical insufficiency
- agitation
- amblyopia
- amenorrhea
- amnesia
- anaphylactic shock
- anaphylactoid reactions
- anemia
- anorexia
- anxiety
- apnea
- appetite stimulation
- arthralgia
- asthenia
- ataxia
- back pain
- biliary obstruction
- bleeding
- blurred vision
- bone fractures
- bone pain
- bradycardia
- cardiac arrest
- chest pain (unspecified)
- chills
- cholestasis
- confusion
- constipation
- cough
- dehydration
- dental caries
- depression
- diaphoresis
- diarrhea
- dizziness
- drowsiness
- dysgeusia
- dyspepsia
- dysphagia
- dysphonia
- dysphoria
- dyspnea
- dysuria
- edema
- elevated hepatic enzymes
- emotional lability
- epistaxis
- eructation
- euphoria
- exfoliative dermatitis
- fatigue
- fever
- flatulence
- flushing
- gastritis
- gastroesophageal reflux
- GI obstruction
- gingivitis
- glossitis
- gonadal suppression
- gout
- hallucinations
- headache
- heart failure
- hematuria
- hiccups
- hyperalgesia
- hyperesthesia
- hyperglycemia
- hyperhidrosis
- hyperkinesis
- hypertension
- hypertonia
- hypochloremia
- hypoesthesia
- hyponatremia
- hypotension
- hypotonia
- ileus
- impaired cognition
- impotence (erectile dysfunction)
- infection
- infertility
- insomnia
- irritability
- laryngospasm
- lethargy
- leukopenia
- libido decrease
- lymphadenopathy
- malaise
- migraine
- miosis
- musculoskeletal pain
- myalgia
- mydriasis
- myoclonia
- nausea
- neonatal opioid withdrawal syndrome
- neutropenia
- night sweats
- orthostatic hypotension
- palpitations
- pancreatitis
- paresthesias
- peripheral edema
- peripheral vasodilation
- pharyngitis
- photosensitivity
- physiological dependence
- polyuria
- pruritus
- psychological dependence
- rash
- respiratory arrest
- respiratory depression
- restlessness
- rhinitis
- seizures
- serotonin syndrome
- SIADH
- sinus tachycardia
- sinusitis
- stomatitis
- suicidal ideation
- syncope
- thrombocytopenia
- thrombosis
- tinnitus
- tolerance
- tremor
- urinary retention
- urticaria
- vertigo
- vomiting
- withdrawal
- xerosis
- xerostomia
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- abrupt discontinuation
- accidental exposure
- acute abdomen
- adrenal insufficiency
- alcoholism
- angina
- asthma
- biliary tract disease
- bladder obstruction
- breast-feeding
- cardiac arrhythmias
- cardiac disease
- children
- chronic obstructive pulmonary disease (COPD)
- CNS depression
- coadministration with other CNS depressants
- coma
- constipation
- cor pulmonale
- dehydration
- depression
- diarrhea
- diverticulitis
- driving or operating machinery
- dysphagia
- esophageal stricture
- ethanol ingestion
- ethanol intoxication
- gastric cancer
- geriatric
- GI disease
- GI obstruction
- head trauma
- heart failure
- hepatic disease
- hypotension
- hypothyroidism
- hypovolemia
- hypoxemia
- ileus
- increased intracranial pressure
- infants
- infertility
- inflammatory bowel disease
- intracranial mass
- labor
- myxedema
- neonatal opioid withdrawal syndrome
- neonates
- obesity
- obstetric delivery
- oliguria
- opiate agonist hypersensitivity
- opioid-naive patients
- orthostatic hypotension
- pancreatitis
- parenteral administration
- potential for overdose or poisoning
- pregnancy
- prostatic hypertrophy
- psychosis
- pulmonary disease
- renal disease
- renal failure
- renal impairment
- reproductive risk
- requires an experienced clinician
- respiratory depression
- respiratory insufficiency
- scoliosis
- seizure disorder
- seizures
- shock
- sleep apnea
- status asthmaticus
- substance abuse
- surgery
- ulcerative colitis
- urethral stricture
- urinary retention
Interactions
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Diphenhydramine
- Acetaminophen; Hydrocodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Tramadol
- Acrivastine; Pseudoephedrine
- Aldesleukin, IL-2
- Alfentanil
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Almotriptan
- Alosetron
- Alprazolam
- Alvimopan
- Amide local anesthetics
- Amifampridine
- Amiloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Amiodarone
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amoxapine
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amphetamine
- Amphetamine; Dextroamphetamine
- Amphetamines
- Anticholinergics
- Apalutamide
- Apomorphine
- Apraclonidine
- Aprepitant, Fosaprepitant
- Aripiprazole
- Armodafinil
- Articaine; Epinephrine
- Asenapine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Atazanavir
- Atazanavir; Cobicistat
- Atenolol; Chlorthalidone
- Atomoxetine
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Azelastine
- Azelastine; Fluticasone
- Azilsartan; Chlorthalidone
- Baclofen
- Barbiturates
- Belladonna; Opium
- Benazepril; Hydrochlorothiazide, HCTZ
- Bendroflumethiazide; Nadolol
- Benzhydrocodone; Acetaminophen
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Benzonatate
- Benzphetamine
- Bethanechol
- Bexarotene
- Bicalutamide
- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
- Bismuth Subsalicylate
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Boceprevir
- Bosentan
- Brexpiprazole
- Brigatinib
- Brimonidine
- Brimonidine; Brinzolamide
- Brimonidine; Timolol
- Brompheniramine
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Dextromethorphan; Guaifenesin
- Brompheniramine; Dextromethorphan; Phenylephrine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Bumetanide
- Bupivacaine
- Bupivacaine Liposomal
- Bupivacaine; Lidocaine
- Buprenorphine
- Buprenorphine; Naloxone
- Bupropion
- Bupropion; Naltrexone
- Buspirone
- Butorphanol
- Candesartan; Hydrochlorothiazide, HCTZ
- Cannabidiol
- Capsaicin; Metaxalone
- Captopril; Hydrochlorothiazide, HCTZ
- Carbamazepine
- Carbetapentane; Chlorpheniramine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbetapentane; Pyrilamine
- Carbinoxamine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Cariprazine
- Carisoprodol
- Cenobamate
- Ceritinib
- Cetirizine
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexbrompheniramine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chloral Hydrate
- Chloramphenicol
- Chlorcyclizine
- Chlordiazepoxide
- Chlordiazepoxide; Clidinium
- Chloroprocaine
- Chlorothiazide
- Chlorpheniramine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Chlorpromazine
- Chlorthalidone
- Chlorthalidone; Clonidine
- Chlorzoxazone
- Cimetidine
- Ciprofloxacin
- Citalopram
- Clarithromycin
- Clemastine
- Clobazam
- Clomipramine
- Clonazepam
- Clonidine
- Clopidogrel
- Clorazepate
- Clozapine
- Cobicistat
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- COMT inhibitors
- Conivaptan
- Crizotinib
- Crofelemer
- Cyclizine
- Cyclobenzaprine
- Cyclosporine
- Cyproheptadine
- Dabrafenib
- Dalfopristin; Quinupristin
- Danazol
- Dantrolene
- Darifenacin
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Deferasirox
- Delavirdine
- Desflurane
- Desipramine
- Desmopressin
- Desvenlafaxine
- Deutetrabenazine
- Dexamethasone
- Dexchlorpheniramine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmedetomidine
- Dexpanthenol
- Dextroamphetamine
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Diazepam
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diltiazem
- Dimenhydrinate
- Diphenhydramine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Diphenhydramine; Phenylephrine
- Dolasetron
- Doxepin
- Doxylamine
- Doxylamine; Pyridoxine
- Dronabinol
- Dronedarone
- Droperidol
- Duloxetine
- Duvelisib
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elagolix
- Elagolix; Estradiol; Norethindrone acetate
- Elbasvir; Grazoprevir
- Eletriptan
- Elexacaftor; tezacaftor; ivacaftor
- Eliglustat
- Eltrombopag
- Eluxadoline
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Enalapril; Hydrochlorothiazide, HCTZ
- Enflurane
- Enzalutamide
- Eprosartan; Hydrochlorothiazide, HCTZ
- Erythromycin
- Erythromycin; Sulfisoxazole
- Escitalopram
- Esketamine
- Eslicarbazepine
- Estazolam
- Eszopiclone
- Ethacrynic Acid
- Ethanol
- Etomidate
- Etravirine
- Everolimus
- Fedratinib
- Fenfluramine
- Fentanyl
- Fesoterodine
- Flibanserin
- Fluconazole
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluphenazine
- Flurazepam
- Fluvoxamine
- Fosamprenavir
- Fosinopril; Hydrochlorothiazide, HCTZ
- Fosphenytoin
- Fospropofol
- Fostamatinib
- Frovatriptan
- Furosemide
- Gabapentin
- Gefitinib
- General anesthetics
- Granisetron
- grapefruit juice
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guanabenz
- Guanfacine
- Haloperidol
- Halothane
- Homatropine; Hydrocodone
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydromorphone
- Hydroxyzine
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Idelalisib
- Iloperidone
- Imatinib
- Imipramine
- Indapamide
- Indinavir
- Isavuconazonium
- Isoflurane
- Isoniazid, INH
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Istradefylline
- Itraconazole
- Ivacaftor
- Ketamine
- Ketoconazole
- Lapatinib
- Larotrectinib
- Lasmiditan
- Lefamulin
- Lemborexant
- Lesinurad
- Lesinurad; Allopurinol
- Letermovir
- Levobupivacaine
- Levocetirizine
- Levomilnacipran
- Levorphanol
- Lidocaine
- Lidocaine; Prilocaine
- Lincosamides
- Linezolid
- Lisdexamfetamine
- Lithium
- Lofexidine
- Loop diuretics
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Lorazepam
- Lorcaserin
- Lorlatinib
- Loxapine
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Lumateperone
- Lurasidone
- Magnesium Salts
- Maprotiline
- Melatonin
- Meperidine
- Meperidine; Promethazine
- Mepivacaine
- Mepivacaine; Levonordefrin
- Meprobamate
- Mesoridazine
- Metaxalone
- Methadone
- Methamphetamine
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methocarbamol
- Methyclothiazide
- Methyldopa
- Methylene Blue
- Methylphenidate
- Metoclopramide
- Metolazone
- Metyrapone
- Metyrosine
- Midazolam
- Mifepristone
- Milnacipran
- Minocycline
- Mirabegron
- Mirtazapine
- Mitotane
- Modafinil
- Molindone
- Monoamine oxidase inhibitors
- Morphine
- Morphine; Naltrexone
- Nabilone
- Nafcillin
- Nalbuphine
- Naloxone
- Naltrexone
- Naproxen; Sumatriptan
- Naratriptan
- Nefazodone
- Nelfinavir
- Nesiritide, BNP
- Netupitant, Fosnetupitant; Palonosetron
- Nevirapine
- Nicardipine
- Nilotinib
- Nitroglycerin
- Nortriptyline
- Octreotide
- Olanzapine
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Ondansetron
- Oritavancin
- Orphenadrine
- Osilodrostat
- Oxazepam
- Oxcarbazepine
- Oxymorphone
- Ozanimod
- Palbociclib
- Paliperidone
- Palonosetron
- Papaverine
- Paroxetine
- Pazopanib
- Peginterferon Alfa-2b
- Pegvisomant
- Pentazocine
- Pentazocine; Naloxone
- Perampanel
- Perindopril; Amlodipine
- Perphenazine
- Perphenazine; Amitriptyline
- Phenothiazines
- Phentermine; Topiramate
- Phenylephrine; Promethazine
- Phenytoin
- Pimozide
- Posaconazole
- Pramipexole
- Pramlintide
- Prasugrel
- Pregabalin
- Prilocaine
- Prilocaine; Epinephrine
- Procaine
- Procarbazine
- Prochlorperazine
- Promethazine
- Propafenone
- Propofol
- Propoxyphene
- Protriptyline
- Quazepam
- Quetiapine
- Quinidine
- Quinine
- Ramelteon
- Ranolazine
- Rasagiline
- Remifentanil
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
- Rifampin
- Rifapentine
- Rifaximin
- Risperidone
- Ritonavir
- Rizatriptan
- Rolapitant
- Ropinirole
- Ropivacaine
- Rotigotine
- Rucaparib
- Safinamide
- Saquinavir
- Selective norepinephrine reuptake inhibitors
- Selegiline
- Selpercatinib
- Serotonin norepinephrine reuptake inhibitors
- Serotonin-Receptor Agonists
- Serotonin-Receptor Antagonists
- Sertraline
- Sevoflurane
- Sibutramine
- Sildenafil
- Simeprevir
- Sodium Oxybate
- Solifenacin
- Spironolactone
- St. John’s Wort, Hypericum perforatum
- Streptogramins
- Sumatriptan
- Suvorexant
- Tapentadol
- Tasimelteon
- Tedizolid
- Telaprevir
- Telithromycin
- Telotristat Ethyl
- Temazepam
- Terbinafine
- Tetrabenazine
- Tetracaine
- Tezacaftor; Ivacaftor
- Thalidomide
- Thiazide diuretics
- Thiethylperazine
- Thioridazine
- Thiothixene
- Ticagrelor
- Tipranavir
- Tizanidine
- Tolterodine
- Topiramate
- Torsemide
- Tramadol
- Trandolapril; Verapamil
- Trazodone
- Triamterene
- Triazolam
- Tricyclic antidepressants
- Trifluoperazine
- Trimethobenzamide
- Trimipramine
- Triprolidine
- Trospium
- Tucatinib
- Valerian, Valeriana officinalis
- Valproic Acid, Divalproex Sodium
- Vemurafenib
- Venlafaxine
- Verapamil
- Vigabatrin
- Vilazodone
- Voriconazole
- Vortioxetine
- Voxelotor
- Zafirlukast
- Zaleplon
- Ziconotide
- Ziprasidone
- Zolmitriptan
- Zolpidem
