Oxycodone Naltrexone Brand Name– TROXYCA ER
What is Oxycodone Naltrexone
Oxycodone naltrexone is an oral combination opioid agonist/opioid antagonist for the management of pain severe enough to require daily, around-the-clock, long-term opioid treatment and for which alternative treatment options are inadequate.
By sequestering naltrexone in the formulation, oxycodone; naltrexone is designed to deter abuse.
Naltrexone is not intended to have a clinical effect when oxycodone; naltrexone is used as directed.
However, if a capsule is crushed or chewed, naltrexone could be released, potentially precipitating withdrawal in opioid-tolerant patients.
Oxycodone naltrexone was FDA-approved in August 2016.
Indications
- severe pain
Side Effects
- abdominal pain
- abnormal dreams
- adrenocortical insufficiency
- agitation
- amenorrhea
- amnesia
- anaphylactoid reactions
- anemia
- anxiety
- apnea
- arthralgia
- asthenia
- ataxia
- back pain
- blurred vision
- bradycardia
- cardiac arrest
- chest pain (unspecified)
- chills
- confusion
- constipation
- cough
- depression
- diaphoresis
- diarrhea
- dizziness
- drowsiness
- dysgeusia
- dyspepsia
- dysphonia
- dysphoria
- dyspnea
- dysuria
- edema
- elevated hepatic enzymes
- emotional lability
- euphoria
- exfoliative dermatitis
- fatigue
- fever
- flushing
- gastritis
- gonadal suppression
- gout
- hallucinations
- headache
- heart failure
- hematuria
- hyperalgesia
- hyperesthesia
- hyperhidrosis
- hypoesthesia
- hypotension
- hypotonia
- impaired cognition
- impotence (erectile dysfunction)
- infertility
- insomnia
- irritability
- lacrimation
- lethargy
- libido decrease
- lymphadenopathy
- malaise
- migraine
- miosis
- myalgia
- nausea
- neonatal opioid withdrawal syndrome
- orthostatic hypotension
- palpitations
- paresthesias
- peripheral edema
- phlebitis
- physiological dependence
- pruritus
- psychological dependence
- rash
- respiratory arrest
- respiratory depression
- restlessness
- rhinorrhea
- seizures
- serotonin syndrome
- sinus tachycardia
- syncope
- thrombosis
- tinnitus
- tremor
- urinary retention
- urticaria
- vertigo
- vomiting
- withdrawal
- xerostomia
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- abrupt discontinuation
- accidental exposure
- adrenal insufficiency
- alcoholism
- angina
- asthma
- biliary tract disease
- bladder obstruction
- breast-feeding
- cardiac arrhythmias
- cardiac disease
- chronic obstructive pulmonary disease (COPD)
- CNS depression
- coadministration with other CNS depressants
- coma
- cor pulmonale
- dehydration
- depression
- driving or operating machinery
- ethanol ingestion
- ethanol intoxication
- geriatric
- GI obstruction
- head trauma
- hepatic disease
- hypotension
- hypothyroidism
- hypovolemia
- hypoxemia
- ileus
- increased intracranial pressure
- infertility
- intracranial mass
- labor
- myxedema
- neonatal opioid withdrawal syndrome
- obesity
- obstetric delivery
- oliguria
- opiate agonist hypersensitivity
- opioid overdose
- opioid use disorder
- opioid-naive patients
- orthostatic hypotension
- pancreatitis
- parenteral administration
- potential for overdose or poisoning
- pregnancy
- prostatic hypertrophy
- psychosis
- pulmonary disease
- renal disease
- renal impairment
- reproductive risk
- requires an experienced clinician
- respiratory depression
- respiratory insufficiency
- scoliosis
- seizure disorder
- seizures
- shock
- sleep apnea
- status asthmaticus
- substance abuse
- urethral stricture
- urinary retention
Interactions
No information is available regarding drug interactions associated with Oxycodone Naltrexone
