Oxycodone Naloxone Brand Name– TARGINIQ
What is Oxycodone Naloxone
Oxycodone naloxone is a semisynthetic opioid agonist (oxycodone) combined with a semisynthetic opioid-receptor antagonist (naloxone) for severe pain requiring daily, around-the-clock, long term opioid treatment for which alternative treatment options are inadequate.
Oxycodone naloxone is designed to deter abuse of oxycodone by snorting or injecting. When crushed and snorted or dissolved and injected, the naloxone in oxycodone; naloxone blocks the euphoric effects of oxycodone.
Oxycodone naloxone was FDA-approved in July 2014.
Indications
- severe pain
Side Effects
- abdominal pain
- adrenocortical insufficiency
- agitation
- amenorrhea
- amnesia
- anaphylactoid reactions
- anxiety
- apnea
- arthralgia
- asthenia
- ataxia
- back pain
- bleeding
- blurred vision
- bradycardia
- cardiac arrest
- chest pain (unspecified)
- chills
- confusion
- constipation
- depression
- diaphoresis
- diarrhea
- dizziness
- drowsiness
- dysgeusia
- dyspepsia
- dysphonia
- dysphoria
- dyspnea
- edema
- emotional lability
- euphoria
- exfoliative dermatitis
- fatigue
- fever
- flushing
- gastritis
- gonadal suppression
- hallucinations
- headache
- heart failure
- hyperalgesia
- hyperesthesia
- hyperhidrosis
- hyperkinesis
- hypertension
- hypoesthesia
- hypotension
- hypotonia
- impotence (erectile dysfunction)
- infertility
- influenza
- insomnia
- lacrimation
- libido decrease
- malaise
- migraine
- miosis
- mydriasis
- nausea
- neonatal opioid withdrawal syndrome
- orthostatic hypotension
- palpitations
- paresthesias
- peripheral edema
- peripheral vasodilation
- physiological dependence
- pruritus
- psychological dependence
- rash
- respiratory arrest
- respiratory depression
- restlessness
- seizures
- serotonin syndrome
- sinus tachycardia
- syncope
- thrombosis
- tremor
- urinary retention
- vertigo
- vomiting
- withdrawal
- xerostomia
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- abrupt discontinuation
- accidental exposure
- adrenal insufficiency
- alcoholism
- angina
- asthma
- biliary tract disease
- bladder obstruction
- breast-feeding
- cardiac arrhythmias
- cardiac disease
- chronic obstructive pulmonary disease (COPD)
- CNS depression
- coadministration with other CNS depressants
- coma
- cor pulmonale
- dehydration
- depression
- driving or operating machinery
- ethanol ingestion
- ethanol intoxication
- geriatric
- GI obstruction
- head trauma
- heart failure
- hepatic disease
- hypotension
- hypothyroidism
- hypovolemia
- hypoxemia
- ileus
- increased intracranial pressure
- infertility
- intracranial mass
- labor
- myxedema
- neonatal opioid withdrawal syndrome
- obesity
- obstetric delivery
- oliguria
- opioid overdose
- opioid use disorder
- opioid-naive patients
- orthostatic hypotension
- pancreatitis
- parenteral administration
- potential for overdose or poisoning
- pregnancy
- prostatic hypertrophy
- psychosis
- pulmonary disease
- renal disease
- renal impairment
- reproductive risk
- requires an experienced clinician
- respiratory depression
- respiratory insufficiency
- scoliosis
- seizure disorder
- seizures
- shock
- sleep apnea
- status asthmaticus
- substance abuse
- urethral stricture
- urinary retention
Interactions
No information is available regarding drug interactions associated with Oxycodone Naloxone
