Oritavancin

Oritavancin Brand Name– ORBACTIV

What is Oritavancin

Oritavancin is a second-generation glycopeptide antibiotic approved for the treatment of acute bacterial skin and skin structure infections (ABSSSI) caused by certain susceptible gram-positive bacteria like Staphylococcus aureus (including methicillin-susceptible and methicillin-resistant strains), various Streptococcus species, and Enterococcus faecalis (vancomycin-susceptible isolates).

Oritavancin inhibits bacterial cell wall biosynthesis and disrupts bacterial cell membrane integrity.

Two clinical trials demonstrated that oritavancin was as effective as vancomycin for the treatment of ABSSSI.

Unlike vancomycin, dosing is not guided by routine serum concentration measurement.

Oritavancin has been shown to artificially prolong the activated partial thromboplastin time (aPTT), prothrombin time (PT), and international normalized ratio (INR).

Use of intravenous unfractionated heparin is contraindicated for 48 hours after oritavancin administration.

Additionally, oritavancin coadministration may result in higher exposure of warfarin; therefore, oritavancin should only be used in patients receiving chronic warfarin therapy when benefit outweighs risk.

The most common adverse effects observed in clinical trials were nausea, headache, vomiting, diarrhea, and the formation of skin and soft tissue abscesses on the arms and legs.

Oritavancin was FDA-approved in August 2014.

Indications

  1. cellulitis
  2. Enterococcus faecalis
  3. Enterococcus faecium
  4. erysipelas
  5. skin and skin structure infections
  6. Staphylococcus aureus (MRSA)
  7. Staphylococcus aureus (MSSA)
  8. Streptococcus agalactiae (group B streptococci)
  9. Streptococcus anginosus
  10. Streptococcus constellatus
  11. Streptococcus dysgalactiae
  12. Streptococcus intermedius
  13. Streptococcus pyogenes (group A beta-hemolytic streptococci)

Side Effects

  1. anemia
  2. angioedema
  3. back pain
  4. bronchospasm
  5. chest pain (unspecified)
  6. chills
  7. diarrhea
  8. dizziness
  9. elevated hepatic enzymes
  10. eosinophilia
  11. erythema
  12. erythema multiforme
  13. flushing
  14. headache
  15. hyperuricemia
  16. hypoglycemia
  17. infection
  18. infusion-related reactions
  19. myalgia
  20. nausea
  21. osteomyelitis
  22. peripheral edema
  23. phlebitis
  24. pruritus
  25. rash
  26. red man syndrome
  27. sinus tachycardia
  28. synovitis
  29. tremor
  30. urticaria
  31. vasculitis
  32. vomiting
  33. wheezing

Monitoring Parameters

  • CBC with differential

Contraindications

  • anticoagulant therapy
  • breast-feeding
  • diarrhea
  • geriatric
  • infusion-related reactions
  • pregnancy
  • pseudomembranous colitis
  • vancomycin hypersensitivity

Interactions

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