What's on this Page
Naloxone Brand Names- EVZIO | Narcan
What is Naloxone
Naloxone is a semisynthetic opioid-receptor antagonist, the n-allyl derivative of oxymorphone. Classically, it is used for complete or partial reversal of opioid-induced respiratory and central nervous system depression.
In emergent situations, naloxone should be administered as an adjunct to supportive or resuscitative measures.
The auto-injector and nasal spray formulations are specific for use in overdose outside of a medical setting; however, they are not substitutes for emergency medical care.
Besides treatment of opioid overdose, naloxone has been used to to address opioid-induced constipation and pruritus.
Naloxone was FDA-approved in 1971.
Indications
- coma
- hypotension
- irritable bowel syndrome
- nausea/vomiting
- opiate agonist dependence diagnosis
- opiate agonist-induced constipation
- opiate agonist-induced respiratory depression
- opioid overdose
- pruritus
- urinary retention
For the treatment of opiate agonist-induced respiratory depression
Side Effects
- agitation
- cardiac arrest
- confusion
- constipation
- dental pain
- dizziness
- dyspnea
- flushing
- hallucinations
- headache
- hot flashes
- hyperhidrosis
- hypertension
- hypotension
- hypoxia
- injection site reaction
- musculoskeletal pain
- nasal congestion
- nasal dryness
- nasal irritation
- nausea
- neonatal abstinence syndrome
- paresthesias
- pulmonary edema
- respiratory depression
- rhinalgia
- seizures
- sinus tachycardia
- tremor
- ventricular fibrillation
- ventricular tachycardia
- vomiting
- withdrawal
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- acute opioid withdrawal
- breast-feeding
- cardiac disease
- infants
- neonates
- paraben hypersensitivity
- pregnancy
- substance abuse
Interactions
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Codeine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Tramadol
- Alfentanil
- Alvimopan
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Oxycodone
- Atazanavir; Cobicistat
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Belladonna; Opium
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Buprenorphine
- Buprenorphine; Naloxone
- Butorphanol
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Cobicistat
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Fentanyl
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Homatropine; Hydrocodone
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydromorphone
- Ibuprofen; Oxycodone
- Levomethadyl
- Levorphanol
- Meperidine
- Meperidine; Promethazine
- Methadone
- Methylnaltrexone
- Morphine
- Morphine; Naltrexone
- Nalbuphine
- Naldemedine
- Naloxegol
- Opiate Agonists-Antagonists
- Oxycodone
- Oxymorphone
- Pentazocine
- Pentazocine; Naloxone
- Propoxyphene
- Remifentanil
- Sufentanil
- Tapentadol
- Tramadol
