Mipomersen Brand Name– Kynamro
What is Mipomersen
Mipomersen an injection administered once weekly, is the first apolipoprotein B (apo B) synthesis inhibitor approved to reduce cholesterol concentrations in patients with homozygous familial hypercholesterolemia (HoFH).
As an adjunct to diet and other medications used to treat hypercholesterolemia, mipomersen further reduces low-density lipoprotein-cholesterol (LDL-C), apo B, total cholesterol, and non-high density lipoprotein-cholesterol (non HDL-C).
Mipomersen (Kynamro) was FDA-approved in January 2013.
Indications
- homozygous familial hypercholesterolemia
For the reduction of low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), apolipoprotein B (Apo-B), and non-high-density lipoprotein cholesterol (non-HDL-C) in patients with homozygous familial hypercholesterolemia (HoFH)
NOTE: Mipomersen is indicated for use as an adjunct to a low-fat diet and in combination with other lipid-lowering medications. The safety and efficacy of mipomersen as an adjunct to LDL apheresis has not been established and is therefore not recommended.
Side Effects
- abdominal pain
- angina
- angioedema
- antibody formation
- chills
- elevated hepatic enzymes
- elevated hepatic enzymes
- erythema
- fatigue
- fever
- glomerulonephritis
- headache
- hematoma
- hepatotoxicity
- hypertension
- influenza
- injection site reaction
- insomnia
- musculoskeletal pain
- nausea
- new primary malignancy
- palpitations
- peripheral edema
- proteinuria
- pruritus
- rash
- skin discoloration
- steatosis
- thrombocytopenia
- urticaria
- vomiting
Monitoring Parameters
- LFTs
- serum alkaline phosphatase
- serum bilirubin
- serum cholesterol profile
Contraindications
- breast-feeding
- contraception requirements
- dialysis
- ethanol ingestion
- geriatric
- hepatic disease
- hepatotoxicity
- low-density lipoprotein apheresis
- pregnancy
- proteinuria
- renal impairment
- reproductive risk
Interactions
- Acetaminophen
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Diphenhydramine
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Pseudoephedrine
- Acetaminophen; Tramadol
- Amiodarone
- Benzhydrocodone; Acetaminophen
- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Demeclocycline
- Doxycycline
- Ethanol
- Isotretinoin
- Lomitapide
- Methotrexate
- Minocycline
- Omadacycline
- Sarecycline
- Tetracycline
- Tetracyclines
