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Metoclopramide Brand Names- Metozolv | Reglan
What is Metoclopramide
Metoclopramide enhances GI motility and is an effective antinauseant. It is chemically related to procainamide and the generic name is derived from the chemical name ‘methoxychloroprocainamide’.
Metoclopramide, however, does not possess local anesthetic or antiarrhythmic properties.
Metoclopramide is useful in treating adults with acute and recurrent diabetic gastroparesis. Treatment for 4 to 12 weeks of symptomatic, documented gastroesophageal reflux disease (GERD) is acceptable in qualified adults who fail to respond to conventional therapy.
Metoclopramide injection is useful in the prevention of postoperative nausea/vomiting (PONV), treatment of chemotherapy-induced nausea and vomiting, helps facilitate intubation of the small bowel, and also helps to stimulate peristalsis during a radiologic examination.
Metoclopramide can cause tardive dyskinesia (TD), a serious movement disorder that is often irreversible. The risk of developing TD increases with the duration of treatment and total cumulative dosage.
A boxed warning regarding TD exists in the metoclopramide product labels; avoid treatment for longer than 12 weeks because of the increased risk of developing TD with longer-term use.
Use of metoclopramide in pediatrics is particularly controversial due to a higher incidence of tardive dyskinesia (TD) and other extrapyramidal symptoms than when the drug is used in adults as well as the risk of methemoglobinemia in neonates.
Safety and effectiveness in pediatric patients have been established to facilitate small bowel intubation.
Safer alternatives are available for most other indications in the pediatric population, but short-term use may be clinically acceptable ‘off-label’ under select circumstances.
Indications
- chemotherapy-induced nausea/vomiting
- chemotherapy-induced nausea/vomiting prophylaxis
- diabetic gastroparesis
- feeding intolerance
- gastroesophageal reflux disease (GERD)
- gastrointestinal radiography
- gastroparesis
- intestinal intubation
- lactation induction
- migraine
- non-small cell lung cancer (NSCLC)
- post-operative nausea/vomiting (PONV)
- post-operative nausea/vomiting (PONV) prophylaxis
- pregnancy-induced nausea/vomiting
- singultus (hiccups)
- Tourette’s syndrome
For the treatment of idiopathic or postsurgical gastroparesis† or diabetic gastroparesis
Side Effects
- agranulocytosis
- akathisia
- amenorrhea
- angioedema
- AV block
- bradycardia
- breast enlargement
- bronchospasm
- confusion
- depression
- diarrhea
- dizziness
- drowsiness
- dyspnea
- dystonic reaction
- edema
- elevated hepatic enzymes
- fatigue
- fluid retention
- galactorrhea
- gynecomastia
- hallucinations
- headache
- heart failure
- hyperprolactinemia
- hypertension
- hypotension
- impotence (erectile dysfunction)
- infertility
- insomnia
- involuntary movements
- jaundice
- laryngeal edema
- laryngospasm
- leukopenia
- menstrual irregularity
- methemoglobinemia
- nausea
- neuroleptic malignant syndrome
- neutropenia
- porphyria
- pseudoparkinsonism
- rash
- restlessness
- seizures
- suicidal ideation
- supraventricular tachycardia (SVT)
- tardive dyskinesia
- torticollis
- tremor
- trismus
- urinary incontinence
- urinary urgency
- urticaria
- visual impairment
- vomiting
- withdrawal
Monitoring Parameters
- serum creatinine/BUN
Contraindications
- abrupt discontinuation
- breast cancer
- breast-feeding
- cardiac disease
- children
- depression
- driving or operating machinery
- G6PD deficiency
- geriatric
- GI bleeding
- GI obstruction
- GI perforation
- heart failure
- hepatic disease
- hyperprolactinemia
- hypertension
- infants
- infertility
- malignant hyperthermia
- methemoglobin reductase deficiency
- methemoglobinemia
- neonates
- paraben hypersensitivity
- Parkinson’s disease
- parkinsonism
- pheochromocytoma
- poor metabolizers
- pregnancy
- procainamide hypersensitivity
- renal failure
- renal impairment
- seizure disorder
- seizures
- tardive dyskinesia
Interactions
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Codeine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Tramadol
- Alfentanil
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Alosetron
- Amantadine
- Amiloride; Hydrochlorothiazide, HCTZ
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amoxapine
- Anticholinergics
- Anxiolytics; Sedatives; and Hypnotics
- Apomorphine
- Aripiprazole
- Artemether; Lumefantrine
- Articaine; Epinephrine
- Asenapine
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atazanavir; Cobicistat
- Atenolol; Chlorthalidone
- Atovaquone
- Atovaquone; Proguanil
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- atypical antipsychotic
- Azilsartan; Chlorthalidone
- Barbiturates
- Belladonna; Opium
- Benazepril; Hydrochlorothiazide, HCTZ
- Bendroflumethiazide; Nadolol
- Benzhydrocodone; Acetaminophen
- Benzodiazepines
- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Brexpiprazole
- Bromocriptine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Bupivacaine
- Bupivacaine Liposomal
- Bupivacaine; Lidocaine
- Bupropion
- Bupropion; Naltrexone
- Buspirone
- Cabergoline
- Candesartan; Hydrochlorothiazide, HCTZ
- Cannabidiol
- Captopril; Hydrochlorothiazide, HCTZ
- Carbidopa; Levodopa
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Cariprazine
- Celecoxib
- Cenobamate
- Chloral Hydrate
- Chloroprocaine
- Chlorothiazide
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorthalidone
- Chlorthalidone; Clonidine
- Cinacalcet
- Ciprofloxacin
- Clozapine
- Cobicistat
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- COMT inhibitors
- Cyclosporine
- Dacomitinib
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Degarelix
- Deutetrabenazine
- Dexmethylphenidate
- Dextromethorphan; Quinidine
- Digoxin
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diphenhydramine; Hydrocodone; Phenylephrine
- dopamine agonists
- Droperidol
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Enalapril; Hydrochlorothiazide, HCTZ
- Entacapone
- Eprosartan; Hydrochlorothiazide, HCTZ
- Esketamine
- Eszopiclone
- Ethanol
- Fenfluramine
- Fenoldopam
- Fentanyl
- Fluoxetine
- Fluoxetine; Olanzapine
- Fosfomycin
- Fosinopril; Hydrochlorothiazide, HCTZ
- Gabapentin
- Goserelin
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Haloperidol
- Histrelin
- Homatropine; Hydrocodone
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydromorphone
- Ibuprofen; Oxycodone
- Iloperidone
- Insulins
- Ipecac
- Isocarboxazid
- Lasmiditan
- Lemborexant
- Leuprolide
- Leuprolide; Norethindrone
- Levodopa
- Levorphanol
- Lidocaine
- Lidocaine; Prilocaine
- Linezolid
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Loxapine
- Lumateperone
- Lurasidone
- Meperidine
- Meperidine; Promethazine
- Mepivacaine
- Mepivacaine; Levonordefrin
- Meprobamate
- Methadone
- Methyclothiazide
- Methylphenidate
- Metolazone
- Metyrosine
- Mivacurium
- Molindone
- Morphine
- Morphine; Naltrexone
- Nabilone
- Olanzapine
- Ombitasvir; Paritaprevir; Ritonavir
- Oritavancin
- Oxycodone
- Oxymorphone
- Paliperidone
- Paroxetine
- Peginterferon Alfa-2b
- Penicillin G Benzathine; Penicillin G Procaine
- Penicillin G Procaine
- Pergolide
- Phenelzine
- Phenothiazines
- Pimozide
- Posaconazole
- Pramipexole
- Pramlintide
- Pregabalin
- Prilocaine
- Prilocaine; Epinephrine
- Quetiapine
- Quinidine
- Ramelteon
- Rasagiline
- Remifentanil
- Risperidone
- Ritonavir
- Rivastigmine
- Ropinirole
- Ropivacaine
- Rotigotine
- Safinamide
- Sedating H1-blockers
- Selegiline
- Sertraline
- Sirolimus
- Succinylcholine
- Sufentanil
- Tacrine
- Tacrolimus
- Tapentadol
- Tedizolid
- Terbinafine
- Tetrabenazine
- Tetracaine
- Tetracycline
- Thiazide diuretics
- Thiothixene
- Tipranavir
- Tolcapone
- Tramadol
- Tranylcypromine
- Triptorelin
- Zalcitabine, ddC
- Zaleplon
- Ziprasidone
- Zolpidem