Metipranolol Brand Name– OptiPranolol
What is Metipranolol
Metipranolol is an ophthalmic, non-selective beta-blocker used to treat chronic open-angle glaucoma or ocular hypertension.
It is similar to ophthalmic timolol in mechanism, onset, and duration of action, but has greater lipophilicity.
In clinical trials, ocular instillation of metipranolol has resulted in a 20—26% reduction of intraocular pressure (IOP).
Metipranolol was approved by the FDA in December, 1989.
Indications
- glaucoma
- ocular hypertension
For the reduction of elevated intraocular pressure (IOP) in patients with open angle glaucoma or ocular hypertension
Side Effects
- angina
- anxiety
- asthenia
- atrial fibrillation
- blepharitis
- blurred vision
- bradycardia
- conjunctivitis
- cough
- depression
- dizziness
- drowsiness
- dyspnea
- edema
- epistaxis
- headache
- hypertension
- lacrimation
- myalgia
- myocardial infarction
- nausea
- ocular irritation
- palpitations
- photophobia
- rash
- rhinitis
- uveitis
Monitoring Parameters
- intraocular pressure
Contraindications
- acute bronchospasm
- asthma
- atopy
- AV block
- bradycardia
- breast-feeding
- bronchitis
- cardiogenic shock
- cerebrovascular disease
- children
- chronic obstructive pulmonary disease (COPD)
- closed-angle glaucoma
- contact lenses
- coronary artery disease
- depression
- diabetes mellitus
- emphysema
- geriatric
- heart failure
- hyperthyroidism
- hypotension
- iritis
- keratitis
- myasthenia gravis
- ocular infection
- ocular surgery
- ocular trauma
- peripheral vascular disease
- pheochromocytoma
- pregnancy
- pulmonary disease
- Raynaud’s phenomenon
- sick sinus syndrome
- surgery
- thyroid disease
- thyrotoxicosis
- uveitis
- vasospastic angina
- ventricular dysfunction
Interactions
There are no drug interactions associated with Metipranolol products.