Metipranolol

Metipranolol Brand Name– OptiPranolol

What is Metipranolol

Metipranolol is an ophthalmic, non-selective beta-blocker used to treat chronic open-angle glaucoma or ocular hypertension.

It is similar to ophthalmic timolol in mechanism, onset, and duration of action, but has greater lipophilicity.

In clinical trials, ocular instillation of metipranolol has resulted in a 20—26% reduction of intraocular pressure (IOP).

Metipranolol was approved by the FDA in December, 1989.

Indications

  • glaucoma
  • ocular hypertension

For the reduction of elevated intraocular pressure (IOP) in patients with open angle glaucoma or ocular hypertension

Side Effects

  1. angina
  2. anxiety
  3. asthenia
  4. atrial fibrillation
  5. blepharitis
  6. blurred vision
  7. bradycardia
  8. conjunctivitis
  9. cough
  10. depression
  11. dizziness
  12. drowsiness
  13. dyspnea
  14. edema
  15. epistaxis
  16. headache
  17. hypertension
  18. lacrimation
  19. myalgia
  20. myocardial infarction
  21. nausea
  22. ocular irritation
  23. palpitations
  24. photophobia
  25. rash
  26. rhinitis
  27. uveitis

Monitoring Parameters

  • intraocular pressure

Contraindications

  • acute bronchospasm
  • asthma
  • atopy
  • AV block
  • bradycardia
  • breast-feeding
  • bronchitis
  • cardiogenic shock
  • cerebrovascular disease
  • children
  • chronic obstructive pulmonary disease (COPD)
  • closed-angle glaucoma
  • contact lenses
  • coronary artery disease
  • depression
  • diabetes mellitus
  • emphysema
  • geriatric
  • heart failure
  • hyperthyroidism
  • hypotension
  • iritis
  • keratitis
  • myasthenia gravis
  • ocular infection
  • ocular surgery
  • ocular trauma
  • peripheral vascular disease
  • pheochromocytoma
  • pregnancy
  • pulmonary disease
  • Raynaud’s phenomenon
  • sick sinus syndrome
  • surgery
  • thyroid disease
  • thyrotoxicosis
  • uveitis
  • vasospastic angina
  • ventricular dysfunction

Interactions

There are no drug interactions associated with Metipranolol products.

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