Methoxsalen Brand Names
8-MOP | Oxsoralen | Oxsoralen-Ultra | UVADEX
What is Methoxsalen
Methoxsalen is a photosensitizing agent. Methoxsalen solution for extracorporeal administration is indicated for the palliative treatment of the skin manifestations of cutaneous T-cell lymphoma that is unresponsive to other forms of treatment.
This formulation is used with the UVAR XTS or CELLEX photopheresis system.
When administered as soft gelatin capsules, methoxsalen is indicated in conjunction with controlled doses of long wave ultraviolet radiation for the symptomatic control of severe, recalcitrant, disabling psoriasis that is not adequately responsive to other forms of therapy and when the diagnosis has been supported by biopsy.
The soft gelatin capsules exhibit significantly greater bioavailability and earlier photosensitization onset time than previous methoxsalen dosage forms (i.e., hard gelatin capsules).
Indications
- alopecia
- cutaneous T-cell lymphoma (CTCL)
- eczema
- lichen planus
- psoriasis
- vitiligo
For the treatment of cutaneous T-cell lymphoma (CTCL)
for the palliative treatment of the skin manifestations of CTCL unresponsive to other forms of treatment, used with the UVAR XTS or CELLEX photopheresis system
Side Effects
- anxiety
- bullous rash
- cataracts
- depression
- dizziness
- dysgeusia
- edema
- erythema
- fever
- folliculitis
- headache
- hypotension
- infection
- insomnia
- malaise
- miliaria
- muscle cramps
- nausea
- new primary malignancy
- photosensitivity
- pruritus
- pulmonary embolism
- rash
- skin hypopigmentation
- thromboembolism
- thrombosis
- urticaria
- vesicular rash
Monitoring Parameters
- antinuclear antibody (ANA) titer
- CBC
- LFTs
- serum electrolytes
- skin cancer screening exam
Contraindications
- albinism
- aphakia
- breast-feeding
- burns
- cardiac disease
- cataracts
- contraception requirements
- geriatric
- hepatic disease
- melanoma
- new primary malignancy
- ocular disease
- porphyria
- pregnancy
- radiation therapy
- reproductive risk
- requires an experienced clinician
- skin cancer
- skin photosensitivity disorder
- sunlight (UV) exposure
- systemic lupus erythematosus (SLE)
- xeroderma pigmentosum
Methoxsalen is contraindicated in patients who have a history of a light sensitive disease/skin photosensitivity disorder such systemic lupus erythematosus (SLE), porphyria cutanea tarda, erythropoietic protoporphyria, variegate porphyria, xeroderma pigmentosum, and albinism
Interactions
- Abciximab
- Acetohexamide
- Adapalene
- Adapalene; Benzoyl Peroxide
- Alefacept
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Allopurinol
- Alpha interferons
- Alteplase
- Amiloride; Hydrochlorothiazide, HCTZ
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Anagrelide
- Anticoagulants
- Antithrombin III
- Apixaban
- Argatroban
- Aspirin, ASA; Dipyridamole
- Atenolol; Chlorthalidone
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Azelastine; Fluticasone
- Azilsartan; Chlorthalidone
- Beclomethasone
- Benazepril; Hydrochlorothiazide, HCTZ
- Bendroflumethiazide; Nadolol
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Betamethasone
- Betrixaban
- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Bivalirudin
- Budesonide
- Budesonide; Formoterol
- Calcium-channel blockers
- Candesartan; Hydrochlorothiazide, HCTZ
- Captopril; Hydrochlorothiazide, HCTZ
- Chlorothiazide
- Chlorpromazine
- Chlorpropamide
- Chlorthalidone
- Chlorthalidone; Clonidine
- Ciclesonide
- Cilostazol
- Clevidipine
- Clopidogrel
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Corticosteroids
- Cortisone
- Dabigatran
- Dalteparin
- Danaparoid
- Deflazacort
- Demeclocycline
- Desirudin
- Dexamethasone
- Dextromethorphan; Promethazine
- Diclofenac
- Diclofenac; Misoprostol
- Digoxin
- Diltiazem
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Dipyridamole
- Doxycycline
- Edoxaban
- Enalapril; Felodipine
- Enalapril; Hydrochlorothiazide, HCTZ
- Enoxaparin
- Eprosartan; Hydrochlorothiazide, HCTZ
- Eptifibatide
- Eravacycline
- Esomeprazole; Naproxen
- Ethotoin
- Etodolac
- Famotidine; Ibuprofen
- Felodipine
- Fenoprofen
- Fludrocortisone
- Flunisolide
- Fluphenazine
- Flurbiprofen
- Fluticasone
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Fondaparinux
- food
- Formoterol; Mometasone
- Fosinopril; Hydrochlorothiazide, HCTZ
- Fosphenytoin
- Glimepiride
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- Glipizide
- Glipizide; Metformin
- Glyburide
- Glyburide; Metformin
- Griseofulvin
- Heparin
- Hydantoins
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocodone; Ibuprofen
- Hydrocortisone
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Indapamide
- Indomethacin
- Interferon Alfa-2a
- Interferon Alfa-2b
- Interferon Alfa-2b; Ribavirin
- Interferon Alfa-n3
- Interferon Alfacon-1
- Isradipine
- Ketoprofen
- Ketorolac
- Lansoprazole; Naproxen
- Lepirudin
- Lesinurad; Allopurinol
- Meclofenamate Sodium
- Mefenamic Acid
- Melatonin
- Meloxicam
- Meperidine; Promethazine
- Mesoridazine
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methotrexate
- Methyclothiazide
- Methylene Blue
- Methylprednisolone
- Metolazone
- Minocycline
- Mometasone
- Nabumetone
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Nicardipine
- Nifedipine
- Nimodipine
- Nisoldipine
- Omadacycline
- Oxaprozin
- Palifermin
- Peginterferon Alfa-2a
- Peginterferon Alfa-2b
- Penicillamine
- Pentosan
- Perindopril; Amlodipine
- Perphenazine
- Perphenazine; Amitriptyline
- Phenothiazines
- Phenylephrine; Promethazine
- Phenytoin
- Piroxicam
- Platelet Inhibitors
- Porfimer
- Prasugrel
- Prednisolone
- Prednisone
- Prochlorperazine
- Promethazine
- Reteplase, r-PA
- Retinoids
- Riluzole
- Rivaroxaban
- Rofecoxib
- Sarecycline
- St. John’s Wort, Hypericum perforatum
- Streptokinase
- Sulfacetamide
- Sulfacetamide; Sulfur
- Sulfonamides
- Sulfonylureas
- Sulindac
- Tenecteplase
- Tetracycline
- Tetracyclines
- Thiazide diuretics
- Thiethylperazine
- Thioridazine
- Thrombolytic Agents
- Ticagrelor
- Ticlopidine
- Tinzaparin
- Tirofiban
- Tolazamide
- Tolbutamide
- Tolmetin
- Trandolapril; Verapamil
- Triamcinolone
- Trifarotene
- Trifluoperazine
- Tuberculin Purified Protein Derivative, PPD
- Urokinase
- Valdecoxib
- Verapamil
- Verteporfin
- Vorapaxar
- Warfarin
- Ziprasidone
