Methoxsalen

Methoxsalen Brand Names

8-MOP | Oxsoralen | Oxsoralen-Ultra | UVADEX

What is Methoxsalen

Methoxsalen is a photosensitizing agent. Methoxsalen solution for extracorporeal administration is indicated for the palliative treatment of the skin manifestations of cutaneous T-cell lymphoma that is unresponsive to other forms of treatment.

This formulation is used with the UVAR XTS or CELLEX photopheresis system.

When administered as soft gelatin capsules, methoxsalen is indicated in conjunction with controlled doses of long wave ultraviolet radiation for the symptomatic control of severe, recalcitrant, disabling psoriasis that is not adequately responsive to other forms of therapy and when the diagnosis has been supported by biopsy.

The soft gelatin capsules exhibit significantly greater bioavailability and earlier photosensitization onset time than previous methoxsalen dosage forms (i.e., hard gelatin capsules).

Indications

  1. alopecia
  2. cutaneous T-cell lymphoma (CTCL)
  3. eczema
  4. lichen planus
  5. psoriasis
  6. vitiligo

For the treatment of cutaneous T-cell lymphoma (CTCL)

for the palliative treatment of the skin manifestations of CTCL unresponsive to other forms of treatment, used with the UVAR XTS or CELLEX photopheresis system

Side Effects

  1. anxiety
  2. bullous rash
  3. cataracts
  4. depression
  5. dizziness
  6. dysgeusia
  7. edema
  8. erythema
  9. fever
  10. folliculitis
  11. headache
  12. hypotension
  13. infection
  14. insomnia
  15. malaise
  16. miliaria
  17. muscle cramps
  18. nausea
  19. new primary malignancy
  20. photosensitivity
  21. pruritus
  22. pulmonary embolism
  23. rash
  24. skin hypopigmentation
  25. thromboembolism
  26. thrombosis
  27. urticaria
  28. vesicular rash

Monitoring Parameters

  • antinuclear antibody (ANA) titer
  • CBC
  • LFTs
  • serum electrolytes
  • skin cancer screening exam

Contraindications

  • albinism
  • aphakia
  • breast-feeding
  • burns
  • cardiac disease
  • cataracts
  • contraception requirements
  • geriatric
  • hepatic disease
  • melanoma
  • new primary malignancy
  • ocular disease
  • porphyria
  • pregnancy
  • radiation therapy
  • reproductive risk
  • requires an experienced clinician
  • skin cancer
  • skin photosensitivity disorder
  • sunlight (UV) exposure
  • systemic lupus erythematosus (SLE)
  • xeroderma pigmentosum

Methoxsalen is contraindicated in patients who have a history of a light sensitive disease/skin photosensitivity disorder such systemic lupus erythematosus (SLE), porphyria cutanea tarda, erythropoietic protoporphyria, variegate porphyria, xeroderma pigmentosum, and albinism

Interactions

  • Abciximab
  • Acetohexamide
  • Adapalene
  • Adapalene; Benzoyl Peroxide
  • Alefacept
  • Aliskiren; Amlodipine
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Allopurinol
  • Alpha interferons
  • Alteplase
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Amlodipine
  • Amlodipine; Atorvastatin
  • Amlodipine; Benazepril
  • Amlodipine; Celecoxib
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
  • Anagrelide
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  • Antithrombin III
  • Apixaban
  • Argatroban
  • Aspirin, ASA; Dipyridamole
  • Atenolol; Chlorthalidone
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Azelastine; Fluticasone
  • Azilsartan; Chlorthalidone
  • Beclomethasone
  • Benazepril; Hydrochlorothiazide, HCTZ
  • Bendroflumethiazide; Nadolol
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Betamethasone
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  • Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
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  • food
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  • Hydrochlorothiazide, HCTZ; Methyldopa
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