Major side effects of cyclosporine and tacrolimus

major toxicities of cyclosporine and tacrolimus?

  • • Decreased renal function (usually reversible with discontinuation of drug).
  • • Hypertension (treat with nifedipine or labetalol).
  • • Anemia (note that does not decrease WBC count).
  • • Malignancies (lymphomas and skin cancers): lymphoma (EBV-related) may regress with stopping drug.
  • • Hyperuricemia and gout (switch to tacrolimus which causes less hyperuricemia).
  • • Bone pain (treat with calcium channel blockers and lower cyclosporine dose).
  • • Others: infections, headaches, tremors, hyperpigmentation, anorexia, hepatotoxicity (rare).
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