Lurbinectedin Brand Name– ZEPZELCA
What is Lurbinectedin
Lurbinectedin is an intravenous alkylating agent. It is indicated for the treatment of metastatic small cell lung cancer (SCLC) with disease progression on or after platinum-based chemotherapy.
Treatment with lurbinectedin is associated with potentially severe myelosuppression; it is more common in patients 65 years of age or older.
Monitor blood counts prior to each dose of lurbinectedin and do not initiate or continue treatment until the neutrophil count is at least 1,500 cells/mm3 and the platelet count is at least 100,000 cells/mm3.
Indications
- small cell lung cancer (SCLC)
For the treatment of small cell lung cancer (SCLC)
for the treatment of metastatic SCLC with disease progression on or after platinum-based chemotherapy, as monotherapy
Side Effects
- abdominal pain
- abdominal pain
- anemia
- anorexia
- anorexia
- arthralgia
- back pain
- bone marrow suppression
- bone pain
- chest pain (unspecified)
- constipation
- cough
- diarrhea
- diarrhea
- dysgeusia
- dyspnea
- dyspnea
- elevated hepatic enzymes
- fatigue
- fatigue
- fever
- headache
- headache
- hepatotoxicity
- hyperesthesia
- hyperglycemia
- hypoalbuminemia
- hypoesthesia
- hypomagnesemia
- hyponatremia
- infection
- infection
- leukopenia
- lymphopenia
- musculoskeletal pain
- musculoskeletal pain
- myalgia
- nausea
- neutropenia
- paresthesias
- peripheral neuropathy
- peripheral neuropathy
- pneumonitis
- thrombocytopenia
- vomiting
Monitoring Parameters
- CBC with differential
- LFTs
- pregnancy testing
Contraindications
- bone marrow suppression
- breast-feeding
- contraception requirements
- geriatric
- hepatic disease
- hepatotoxicity
- male-mediated teratogenicity
- neutropenia
- pregnancy
- pregnancy testing
- reproductive risk
- thrombocytopenia
Interactions
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Amiodarone
- Amobarbital
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Apalutamide
- Aprepitant, Fosaprepitant
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Atazanavir
- Atazanavir; Cobicistat
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Bexarotene
- Bosentan
- Brigatinib
- Butabarbital
- Carbamazepine
- Cenobamate
- Ceritinib
- Chloramphenicol
- Ciprofloxacin
- Clarithromycin
- Cobicistat
- Conivaptan
- Crizotinib
- Cyclosporine
- Dabrafenib
- Danazol
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Delavirdine
- Dexamethasone
- Diltiazem
- Dronedarone
- Duvelisib
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elagolix
- Elagolix; Estradiol; Norethindrone acetate
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Enzalutamide
- Erythromycin
- Erythromycin; Sulfisoxazole
- Eslicarbazepine
- Etravirine
- Fedratinib
- Fluconazole
- Fluvoxamine
- Fosamprenavir
- Fosphenytoin
- grapefruit juice
- Idelalisib
- Imatinib
- Indinavir
- Isavuconazonium
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Itraconazole
- Ketoconazole
- Letermovir
- Lopinavir; Ritonavir
- Lorlatinib
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Mephobarbital
- Methohexital
- Mifepristone
- Mitotane
- Nafcillin
- Nefazodone
- Nelfinavir
- Netupitant, Fosnetupitant; Palonosetron
- Nevirapine
- Nilotinib
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Pentobarbital
- Phenobarbital
- Phenytoin
- Posaconazole
- Primidone
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
- Rifampin
- Rifapentine
- Ritonavir
- Saquinavir
- Secobarbital
- St. John’s Wort, Hypericum perforatum
- Telithromycin
- Thiopental
- Tipranavir
- Trandolapril; Verapamil
- Tucatinib
- Verapamil
- Voriconazole
