Luspatercept

Luspatercept Brand Name– REBLOZYL

What is Luspatercept

Luspatercept is an erythroid maturation agent. It is indicated for the treatment of anemia in adult patients with beta thalassemia who require regular red blood cell (RBC) transfusions and adult patients with very low- to intermediate-risk myelodysplastic syndromes (MDS) with ring sideroblasts or with MDS/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis who failed an erythropoiesis stimulating agent and require 2 or more RBC units over an 8-week period.

Thromboembolism has been reported in luspatercept-treated patients; monitor for signs and symptoms of thromboembolism and initiate prophylaxis in at-risk patients.

Indications

  • anemia
  • myelodysplastic syndrome (MDS)

For the treatment of anemia in patients with beta thalassemia who require regular red blood cell transfusions

NOTE: Luspatercept is not indicated as a substitute for RBC transfusions in patients who require immediate correction of anemia.

Side Effects

  1. abdominal pain
  2. antibody formation
  3. arthralgia
  4. asthenia
  5. bone pain
  6. bone pain
  7. cough
  8. diarrhea
  9. diarrhea
  10. dizziness
  11. dizziness
  12. dyspnea
  13. dyspnea
  14. elevated hepatic enzymes
  15. fatigue
  16. fatigue
  17. headache
  18. headache
  19. hyperbilirubinemia
  20. hypertension
  21. hypertension
  22. hypertensive crisis
  23. hyperuricemia
  24. hyperuricemia
  25. infection
  26. infection
  27. influenza
  28. injection site reaction
  29. musculoskeletal pain
  30. musculoskeletal pain
  31. nausea
  32. nausea
  33. nephrotoxicity
  34. new primary malignancy
  35. pulmonary embolism
  36. sinus tachycardia
  37. stroke
  38. syncope
  39. syncope
  40. thromboembolism
  41. thrombosis
  42. vertigo
  43. vertigo

Monitoring Parameters

  • blood pressure
  • hemoglobin/hematocrit
  • pregnancy testing

Contraindications

  • anemia
  • breast-feeding
  • children
  • contraception requirements
  • hypertension
  • infants
  • infertility
  • neonates
  • pregnancy
  • pregnancy testing
  • reproductive risk
  • thromboembolism
  • thrombosis
  • tobacco smoking

Interactions

There are no drug interactions associated with Luspatercept products.