Lurasidone

Lurasidone Brand Name– Latuda

What is Lurasidone

Lurasidone is an oral atypical antipsychotic belonging to the benzisoxazole/benzoisothiazol derivatives class.

Atypical antipsychotics such as lurasidone are first-line treatment options for the management of schizophrenia and related disorders, with the exception of clozapine. Clinically, lurasidone is effective for the positive and negative symptoms of schizophrenia.

Some atypical antipsychotics, including lurasidone, have demonstrated efficacy in treating bipolar depression. Lurasidone is indicated for the treatment of schizophrenia in adults and adolescents and is also used to treat depressive episodes associated with bipolar I disorder in adults and pediatric patients 10 years of age and older.

Compared to conventional antipsychotics, atypical antipsychotics generally have a lower potential for extrapyramidal side effects. Due to extensive metabolism through CYP3A4, lurasidone is contraindicated for use with strong CYP3A4 inhibitors and strong CYP3A4 inducers.

As with all antipsychotics, lurasidone carries a boxed warning for increased mortality in elderly patients with dementia-related psychosis

Indications

1. behavioral or psychological symptoms of dementia
2. bipolar depression
3. schizophrenia

Side Effects

1. abdominal pain
2. abnormal dreams
3. agitation
4. agranulocytosis
5. akathisia
6. amenorrhea
7. anemia
8. angina
9. angioedema
10. anxiety
11. appetite stimulation
12. AV block
13. back pain
14. blurred vision
15. bradycardia
16. breast enlargement
17. diabetes mellitus
18. diabetic ketoacidosis
19. diarrhea
20. dizziness
21. drowsiness
22. dysarthria
23. dyskinesia
24. dysmenorrhea
25. dyspepsia
26. dysphagia
27. dyspnea
28. dystonic reaction
29. dysuria
30. fatigue
31. galactorrhea
32. gastritis
33. hypercholesterolemia
34. hyperglycemia
35. hyperlipidemia
36. hyperprolactinemia
37. hypersalivation
38. hypertension
39. hyperthermia
40. hypertriglyceridemia
41. hyponatremia
42. impotence (erectile dysfunction)
43. infection
44. influenza
45. insomnia
46. leukopenia
47. libido decrease
48. mastalgia
49. nasal congestion
50. nausea
51. neuroleptic malignant syndrome
52. neutropenia
53. orthostatic hypotension
54. pharyngitis
55. polydipsia
56. priapism
57. pruritus
58. pseudoparkinsonism
59. QT prolongation
60. rash
61. renal failure (unspecified)
62. restlessness
63. rhabdomyolysis
64. rhinitis
65. rhinorrhea
66. seizures
67. SIADH
68. sinus tachycardia
69. stroke
70. suicidal ideation
71. syncope
72. tardive dyskinesia
73. urticaria
74. vertigo
75. vomiting
76. water intoxication
77. weight gain
78. xerostomia

Monitoring Parameters

• AIMS assessment
• blood glucose
• CBC
• glycosylated hemoglobin A1c (HbA1c)
• LFTs
• neurologic function
• pregnancy testing
• serum creatinine
• serum electrolytes
• serum lipid profile
• serum prolactin
• thyroid function tests (TFTs)
• weight

Contraindications

• abrupt discontinuation
• agranulocytosis
• ambient temperature increase
• breast cancer
• breast-feeding
• cardiac disease
• cerebrovascular disease
• children
• coadministration with other CNS depressants
• dehydration
• dementia
• diabetes mellitus
• diabetic ketoacidosis
• driving or operating machinery
• dysphagia
• ethanol ingestion
• geriatric
• heart failure
• hematological disease
• hepatic disease
• hypercholesterolemia
• hyperglycemia
• hyperlipidemia
• hyperprolactinemia
• hyperthermia
• hypertriglyceridemia
• hypotension
• hypothermia
• hypovolemia
• infertility
• leukopenia
• long QT syndrome
• myocardial infarction
• neonates
• neurological disease
• neutropenia
• obesity
• orthostatic hypotension
• Parkinson’s disease
• pregnancy
• pregnancy testing
• QT prolongation
• renal disease
• renal failure
• renal impairment
• seizure disorder
• seizures
• strenuous exercise
• stroke
• substance abuse
• suicidal ideation
• syncope
• tardive dyskinesia

Lurasidone is contraindicated in patients with a hypersensitivity to lurasidone or any other component of the commercial product. Angioedema has been observed with lurasidone use

Interactions

• Acarbose
• Acebutolol
• Acetaminophen; Butalbital
• Acetaminophen; Butalbital; Caffeine
• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Caffeine; Dihydrocodeine
• Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
• Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
• Acetaminophen; Codeine
• Acetaminophen; Dextromethorphan; Doxylamine
• Acetaminophen; Dichloralphenazone; Isometheptene
• Acetaminophen; Diphenhydramine
• Acetaminophen; Hydrocodone
• Acetaminophen; Oxycodone
• Acetaminophen; Pentazocine
• Acetaminophen; Propoxyphene
• Acetaminophen; Tramadol
• Acrivastine; Pseudoephedrine
• Albiglutide
• Aldesleukin, IL-2
• Alfentanil
• Aliskiren
• Aliskiren; Amlodipine
• Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
• Aliskiren; Hydrochlorothiazide, HCTZ
• Aliskiren; Valsartan
• Alogliptin
• Alogliptin; Metformin
• Alogliptin; Pioglitazone
• Alpha-blockers
• Alpha-glucosidase Inhibitors
• Alprazolam
• Ambrisentan
• Amifampridine
• Amiloride
• Amiloride; Hydrochlorothiazide, HCTZ
• Amiodarone
• Amitriptyline; Chlordiazepoxide
• Amlodipine
• Amlodipine; Atorvastatin
• Amlodipine; Benazepril
• Amlodipine; Celecoxib
• Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
• Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
• Amlodipine; Olmesartan
• Amlodipine; Telmisartan
• Amlodipine; Valsartan
• Amobarbital
• Amoxapine
• Amoxicillin; Clarithromycin; Lansoprazole
• Amoxicillin; Clarithromycin; Omeprazole
• Amphetamine
• Amphetamine; Dextroamphetamine
• Amphetamines
• Amprenavir
• Angiotensin II receptor antagonists
• Angiotensin-converting enzyme inhibitors
• Anticholinergics
• Apalutamide
• Apomorphine
• Aprepitant, Fosaprepitant
• Aripiprazole
• Asenapine
• Aspirin, ASA; Butalbital; Caffeine
• Aspirin, ASA; Butalbital; Caffeine; Codeine
• Aspirin, ASA; Caffeine; Dihydrocodeine
• Aspirin, ASA; Carisoprodol; Codeine
• Aspirin, ASA; Oxycodone
• Atazanavir
• Atazanavir; Cobicistat
• Atenolol
• Atenolol; Chlorthalidone
• Atropine
• Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
• Atropine; Difenoxin
• Atropine; Diphenoxylate
• Atropine; Edrophonium
• Atropine; Hyoscyamine; Phenobarbital; Scopolamine
• Azilsartan
• Azilsartan; Chlorthalidone
• Barbiturates
• Belladonna Alkaloids; Ergotamine; Phenobarbital
• Belladonna; Opium
• Benazepril
• Benazepril; Hydrochlorothiazide, HCTZ
• Bendroflumethiazide; Nadolol
• Benzhydrocodone; Acetaminophen
• Benzodiazepines
• Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
• Benzphetamine
• Benztropine
• Beta-adrenergic blockers
• Betaxolol
• Bexarotene
• Bisoprolol
• Bisoprolol; Hydrochlorothiazide, HCTZ
• Boceprevir
• Bosentan
• Brexpiprazole
• Brigatinib
• Brimonidine; Timolol
• Bromocriptine
• Brompheniramine
• Brompheniramine; Carbetapentane; Phenylephrine
• Brompheniramine; Dextromethorphan; Guaifenesin
• Brompheniramine; Dextromethorphan; Phenylephrine
• Brompheniramine; Guaifenesin; Hydrocodone
• Brompheniramine; Hydrocodone; Pseudoephedrine
• Brompheniramine; Pseudoephedrine
• Bumetanide
• Buprenorphine
• Buprenorphine; Naloxone
• Bupropion
• Bupropion; Naltrexone
• Buspirone
• Butabarbital
• Butorphanol
• Cabergoline
• Canagliflozin
• Canagliflozin; Metformin
• Candesartan
• Candesartan; Hydrochlorothiazide, HCTZ
• Cannabidiol
• Captopril
• Captopril; Hydrochlorothiazide, HCTZ
• Carbamazepine
• Carbetapentane; Chlorpheniramine
• Carbetapentane; Chlorpheniramine; Phenylephrine
• Carbetapentane; Diphenhydramine; Phenylephrine
• Carbetapentane; Guaifenesin
• Carbetapentane; Guaifenesin; Phenylephrine
• Carbetapentane; Phenylephrine
• Carbetapentane; Phenylephrine; Pyrilamine
• Carbetapentane; Pseudoephedrine
• Carbetapentane; Pyrilamine
• Carbidopa
• Carbidopa; Levodopa
• Carbidopa; Levodopa; Entacapone
• Carbinoxamine
• Carbinoxamine; Dextromethorphan; Pseudoephedrine
• Carbinoxamine; Hydrocodone; Phenylephrine
• Carbinoxamine; Hydrocodone; Pseudoephedrine
• Carbinoxamine; Phenylephrine
• Carbinoxamine; Pseudoephedrine
• Cariprazine
• Carteolol
• Carvedilol
• Cenobamate
• Central-acting adrenergic agents
• Ceritinib
• Cetirizine
• Cetirizine; Pseudoephedrine
• Cetrorelix
• Chlophedianol; Dexbrompheniramine
• Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
• Chloramphenicol
• Chlorcyclizine
• Chlordiazepoxide
• Chlordiazepoxide; Clidinium
• Chlorothiazide
• Chlorpheniramine
• Chlorpheniramine; Codeine
• Chlorpheniramine; Dextromethorphan
• Chlorpheniramine; Dextromethorphan; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
• Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Hydrocodone
• Chlorpheniramine; Hydrocodone; Phenylephrine
• Chlorpheniramine; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Phenylephrine
• Chlorpheniramine; Pseudoephedrine
• Chlorpromazine
• Chlorthalidone
• Chlorthalidone; Clonidine
• Cimetidine
• Clarithromycin
• Clemastine
• Clevidipine
• Clobazam
• Clonazepam
• Clonidine
• Clorazepate
• Clozapine
• Cobicistat
• Codeine
• Codeine; Guaifenesin
• Codeine; Phenylephrine; Promethazine
• Codeine; Promethazine
• COMT inhibitors
• Conivaptan
• Crizotinib
• Cyclizine
• Cyproheptadine
• Dabrafenib
• Danazol
• Dapagliflozin
• Dapagliflozin; Metformin
• Dapagliflozin; Saxagliptin
• Darunavir
• Darunavir; Cobicistat
• Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
• Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
• Delavirdine
• Deutetrabenazine
• Dexamethasone
• Dexchlorpheniramine
• Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
• Dexmethylphenidate
• Dextroamphetamine
• Dextromethorphan; Diphenhydramine; Phenylephrine
• Dextromethorphan; Promethazine
• Diazepam
• Diazoxide
• Dicyclomine
• Dihydrocodeine; Guaifenesin; Pseudoephedrine
• Diltiazem
• Dimenhydrinate
• Dipeptidyl Peptidase-4 Inhibitors
• Diphenhydramine
• Diphenhydramine; Hydrocodone; Phenylephrine
• Diphenhydramine; Ibuprofen
• Diphenhydramine; Naproxen
• Diphenhydramine; Phenylephrine
• Dorzolamide; Timolol
• Doxazosin
• Doxepin
• Doxylamine
• Doxylamine; Pyridoxine
• Dronabinol
• Dronedarone
• Droperidol
• Dulaglutide
• Duvelisib
• Efavirenz
• Efavirenz; Emtricitabine; Tenofovir
• Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
• Elbasvir; Grazoprevir
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
• Empagliflozin
• Empagliflozin; Linagliptin
• Empagliflozin; Linagliptin; Metformin
• Empagliflozin; Metformin
• Enalapril, Enalaprilat
• Enalapril; Felodipine
• Enalapril; Hydrochlorothiazide, HCTZ
• Encorafenib
• Entacapone
• Enzalutamide
• Eplerenone
• Epoprostenol
• Eprosartan
• Eprosartan; Hydrochlorothiazide, HCTZ
• Ertugliflozin
• Ertugliflozin; Metformin
• Ertugliflozin; Sitagliptin
• Erythromycin
• Erythromycin; Sulfisoxazole
• Esketamine
• Eslicarbazepine
• Esmolol
• Estazolam
• Eszopiclone
• Ethacrynic Acid
• Ethanol
• Ethotoin
• Etravirine
• Exenatide
• Fedratinib
• Felodipine
• Fenfluramine
• Fenoldopam
• Fentanyl
• Flavoxate
• Fluconazole
• Fluoxetine
• Fluoxetine; Olanzapine
• Fluphenazine
• Flurazepam
• Fluvoxamine
• food
• Fosamprenavir
• Fosinopril
• Fosinopril; Hydrochlorothiazide, HCTZ
• Fosphenytoin
• Furosemide
• Gabapentin
• Ganirelix
• Glimepiride; Pioglitazone
• Glimepiride; Rosiglitazone
• Glipizide; Metformin
• Glyburide; Metformin
• Glycopyrrolate
• Glycopyrrolate; Formoterol
• grapefruit juice
• Guaifenesin; Hydrocodone
• Guaifenesin; Hydrocodone; Pseudoephedrine
• Guanabenz
• Guanfacine
• Haloperidol
• Homatropine; Hydrocodone
• Hydralazine
• Hydralazine; Hydrochlorothiazide, HCTZ
• Hydralazine; Isosorbide Dinitrate, ISDN
• Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ; Irbesartan
• Hydrochlorothiazide, HCTZ; Lisinopril
• Hydrochlorothiazide, HCTZ; Losartan
• Hydrochlorothiazide, HCTZ; Methyldopa
• Hydrochlorothiazide, HCTZ; Metoprolol
• Hydrochlorothiazide, HCTZ; Moexipril
• Hydrochlorothiazide, HCTZ; Olmesartan
• Hydrochlorothiazide, HCTZ; Propranolol
• Hydrochlorothiazide, HCTZ; Quinapril
• Hydrochlorothiazide, HCTZ; Spironolactone
• Hydrochlorothiazide, HCTZ; Telmisartan
• Hydrochlorothiazide, HCTZ; Triamterene
• Hydrochlorothiazide, HCTZ; Valsartan
• Hydrocodone
• Hydrocodone; Ibuprofen
• Hydrocodone; Phenylephrine
• Hydrocodone; Potassium Guaiacolsulfonate
• Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
• Hydrocodone; Pseudoephedrine
• Hydromorphone
• Hydroxyzine
• Hyoscyamine
• Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
• Ibuprofen; Oxycodone
• Idelalisib
• Iloperidone
• Iloprost
• Imatinib
• Incretin Mimetics
• Indacaterol; Glycopyrrolate
• Indapamide
• Indinavir
• Insulin Degludec; Liraglutide
• Insulin Glargine; Lixisenatide
• Insulins
• Iohexol
• Iopamidol
• Iopromide
• Ioversol
• Irbesartan
• Isavuconazonium
• Isocarboxazid
• Isoniazid, INH; Pyrazinamide, PZA; Rifampin
• Isoniazid, INH; Rifampin
• Isosulfan Blue
• Isradipine
• Itraconazole
• Ivosidenib
• Ketoconazole
• Labetalol
• Lasmiditan
• Lefamulin
• Lemborexant
• Lesinurad
• Lesinurad; Allopurinol
• Letermovir
• Levobetaxolol
• Levobunolol
• Levocetirizine
• Levodopa
• Levorphanol
• Linagliptin
• Linagliptin; Metformin
• Liraglutide
• Lisdexamfetamine
• Lisinopril
• Lithium
• Lixisenatide
• Lofexidine
• Loop diuretics
• Lopinavir; Ritonavir
• Lorazepam
• Lorlatinib
• Losartan
• Loxapine
• Lumacaftor; Ivacaftor
• Lumateperone
• Macitentan
• Mecamylamine
• Meclizine
• Meglitinides
• Mepenzolate
• Meperidine
• Meperidine; Promethazine
• Mephobarbital
• Meprobamate
• Metformin
• Metformin; Pioglitazone
• Metformin; Repaglinide
• Metformin; Rosiglitazone
• Metformin; Saxagliptin
• Metformin; Sitagliptin
• Methadone
• Methamphetamine
• Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
• Methohexital
• Methscopolamine
• Methyclothiazide
• Methyldopa
• Methylphenidate
• Metoclopramide
• Metolazone
• Metoprolol
• Midazolam
• Mifepristone
• Miglitol
• Minoxidil
• Mitotane
• Modafinil
• Moexipril
• Molindone
• Monoamine oxidase inhibitors
• Morphine
• Morphine; Naltrexone
• Nabilone
• Nadolol
• Nafarelin
• Nalbuphine
• Nateglinide
• Nebivolol
• Nebivolol; Valsartan
• Nefazodone
• Nelfinavir
• Netupitant, Fosnetupitant; Palonosetron
• Nevirapine
• Nicardipine
• Nifedipine
• Nilotinib
• Nisoldipine
• Nitroprusside
• Non-Ionic Contrast Media
• Octreotide
• Olanzapine
• Olmesartan
• Ombitasvir; Paritaprevir; Ritonavir
• Omeprazole; Amoxicillin; Rifabutin
• Opiate Agonists
• Oritavancin
• Oxazepam
• Oxybutynin
• Oxycodone
• Oxymorphone
• Paliperidone
• Penbutolol
• Pentazocine
• Pentazocine; Naloxone
• Pentobarbital
• Pergolide
• Perindopril
• Perindopril; Amlodipine
• Perphenazine
• Perphenazine; Amitriptyline
• Pexidartinib
• Phenelzine
• Phenobarbital
• Phenoxybenzamine
• Phentermine; Topiramate
• Phentolamine
• Phenylephrine; Promethazine
• Phenytoin
• Pimozide
• Pindolol
• Pioglitazone
• Posaconazole
• Potassium-sparing diuretics
• Pramipexole
• Pramlintide
• Prazosin
• Pregabalin
• Primidone
• Prochlorperazine
• Promethazine
• Propantheline
• Propoxyphene
• Propranolol
• Quazepam
• Quetiapine
• Quinapril
• Quinine
• Ramelteon
• Ramipril
• Ranolazine
• Rasagiline
• Remifentanil
• Repaglinide
• Reserpine
• Ribociclib
• Ribociclib; Letrozole
• Rifabutin
• Rifampin
• Rifapentine
• Riociguat
• Risperidone
• Ritonavir
• Ropinirole
• Rosiglitazone
• Rotigotine
• Sacubitril; Valsartan
• Safinamide
• Saquinavir
• Saxagliptin
• Scopolamine
• Secobarbital
• Sedating H1-blockers
• Selegiline
• Selexipag
• Semaglutide
• SGLT2 Inhibitors
• Sibutramine
• Sildenafil
• Simeprevir
• Simvastatin; Sitagliptin
• Sitagliptin
• Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
• Solifenacin
• Spironolactone
• St. John’s Wort, Hypericum perforatum
• Sufentanil
• Sulfonylureas
• Suvorexant
• Tadalafil
• Tasimelteon
• Telithromycin
• Telmisartan
• Telotristat Ethyl
• Temazepam
• Terazosin
• Tetrabenazine
• Thalidomide
• Thiazide diuretics
• Thiopental
• Thioridazine
• Thiothixene
• Timolol
• Tipranavir
• Tizanidine
• Tolcapone
• Tolterodine
• Topiramate
• Torsemide
• Tramadol
• Trandolapril
• Trandolapril; Verapamil
• Tranylcypromine
• Treprostinil
• Triamterene
• Triazolam
• Trifluoperazine
• Trihexyphenidyl
• Triprolidine
• Trospium
• Tucatinib
• Valsartan
• Vemurafenib
• Verapamil
• Voriconazole
• Zafirlukast
• Zaleplon
• Ziprasidone
• Zolpidem
• Zonisamide