Lorcaserin

Lorcaserin Brand Names- Belviq | Belviq XR

What is Lorcaserin

Lorcaserin is an oral serotonin-2C (5-HT2C) receptor agonist used as an adjunct to lifestyle modifications for weight loss and chronic weight management in obese adults, or in overweight adults in the presence of at least 1 weight-related comorbidity (e.g., hypertension, dyslipidemia, type 2 diabetes).

Long-term use of lorcaserin has been associated with an average weight loss of 4% to 4.5% during clinical trials and 47.2% of patients lost 5% or more of their baseline body weight.

Favorable changes in glycemic control have been noted in addition to weight loss in those with type 2 diabetes mellitus.

According to the American Association of Clinical Endocrinologists and American College of Endocrinology (AACE/ACE) Obesity Clinical Practice Guidelines, weight loss medications should be offered as chronic treatment along with lifestyle modifications to obese patients when the potential benefits outweigh the risks.

Short-term pharmacotherapy has not been shown to produce longer-term health benefits and cannot be generally recommended.

A generalized hierarchy for medication preferences that would be applicable to all obese patients cannot currently be scientifically justified. Individualized weight loss pharmacotherapy is recommended, based upon factors such as the specific characteristics of each weight-loss medication, the presence of weight-related complications, and the medical history of the patient

Indications

  • obesity
  • weight management

For the treatment of obesity and for chronic weight management as an adjunct to a reduced-calorie diet and increased physical activity

Side Effects

  1. anxiety
  2. back pain
  3. blurred vision
  4. bradycardia
  5. cardiac valvulopathy
  6. chills
  7. confusion
  8. conjunctivitis
  9. constipation
  10. cough
  11. dental pain
  12. depression
  13. diarrhea
  14. dizziness
  15. drowsiness
  16. euphoria
  17. fatigue
  18. headache
  19. hyperhidrosis
  20. hyperprolactinemia
  21. hypertension
  22. hypoglycemia
  23. impaired cognition
  24. infection
  25. insomnia
  26. leukopenia
  27. lymphopenia
  28. memory impairment
  29. muscle cramps
  30. musculoskeletal pain
  31. nausea
  32. neuroleptic malignant syndrome-like symptoms
  33. neutropenia
  34. new primary malignancy
  35. peripheral edema
  36. rash
  37. serotonin syndrome
  38. suicidal ideation
  39. tremor
  40. visual impairment
  41. vomiting
  42. xerophthalmia
  43. xerostomia

Monitoring Parameters

  • blood glucose
  • CBC with differential
  • hemoglobin/hematocrit
  • serum prolactin
  • weight

Contraindications

  • alcoholism
  • anemia
  • anorexia nervosa
  • AV block
  • bariatric surgery
  • bradycardia
  • breast-feeding
  • bulimia nervosa
  • bundle-branch block
  • children
  • contraception requirements
  • depression
  • diabetes mellitus
  • dialysis
  • driving or operating machinery
  • geriatric
  • heart failure
  • hepatic disease
  • hyperprolactinemia
  • hypoglycemia
  • infants
  • labor
  • leukemia
  • leukopenia
  • MAOI therapy
  • multiple myeloma
  • neutropenia
  • new primary malignancy
  • obstetric delivery
  • Peyronie’s disease
  • pregnancy
  • priapism
  • pulmonary hypertension
  • renal disease
  • renal failure
  • renal impairment
  • schizophrenia
  • sick sinus syndrome
  • sickle cell disease
  • substance abuse
  • suicidal ideation
  • valvular heart disease

Lorcaserin is contraindicated in patients with prior hypersensitivity to lorcaserin or to any of the product components. Hypersensitivity reactions have been reported.

Interactions

  • Acarbose
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Tramadol
  • Acetohexamide
  • Albiglutide
  • Alfentanil
  • Alogliptin
  • Alogliptin; Metformin
  • Alogliptin; Pioglitazone
  • Alpha-glucosidase Inhibitors
  • Amitriptyline
  • Amitriptyline; Chlordiazepoxide
  • Amphetamines
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Oxycodone
  • Atazanavir; Cobicistat
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Brompheniramine; Dextromethorphan; Guaifenesin
  • Brompheniramine; Dextromethorphan; Phenylephrine
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Bupropion
  • Bupropion; Naltrexone
  • Cabergoline
  • Canagliflozin; Metformin
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dextromethorphan
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpropamide
  • Citalopram
  • Clomipramine
  • Cobicistat
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Dapagliflozin; Metformin
  • Dapagliflozin; Saxagliptin
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Degarelix
  • Desipramine
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dextromethorphan
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Guaifenesin
  • Dextromethorphan; Guaifenesin; Phenylephrine
  • Dextromethorphan; Guaifenesin; Potassium Guaiacolsulfonate
  • Dextromethorphan; Guaifenesin; Pseudoephedrine
  • Dextromethorphan; Promethazine
  • Dextromethorphan; Quinidine
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Dipeptidyl Peptidase-4 Inhibitors
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Doxepin
  • Doxorubicin
  • Dulaglutide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Empagliflozin; Linagliptin
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • Ergot alkaloids
  • Ertugliflozin; Metformin
  • Ertugliflozin; Sitagliptin
  • Escitalopram
  • Exenatide
  • Fenfluramine
  • Fentanyl
  • Fluoxetine
  • Fluoxetine; Olanzapine
  • Fluvoxamine
  • Glimepiride
  • Glimepiride; Pioglitazone
  • Glimepiride; Rosiglitazone
  • Glipizide
  • Glipizide; Metformin
  • Glyburide
  • Glyburide; Metformin
  • Goserelin
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Histrelin
  • Homatropine; Hydrocodone
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydromorphone
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Ibuprofen; Oxycodone
  • Imipramine
  • Incretin Mimetics
  • Insulin Degludec; Liraglutide
  • Insulin Glargine; Lixisenatide
  • Insulins
  • Lasmiditan
  • Leuprolide
  • Leuprolide; Norethindrone
  • Levorphanol
  • Linagliptin
  • Linagliptin; Metformin
  • Linezolid
  • Liraglutide
  • Lithium
  • Lixisenatide
  • Loperamide
  • Loperamide; Simethicone
  • Meglitinides
  • Meperidine
  • Meperidine; Promethazine
  • Metformin
  • Metformin; Pioglitazone
  • Metformin; Repaglinide
  • Metformin; Rosiglitazone
  • Metformin; Saxagliptin
  • Metformin; Sitagliptin
  • Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
  • Methylene Blue
  • Miglitol
  • Monoamine oxidase inhibitors
  • Morphine
  • Morphine; Naltrexone
  • Nalbuphine
  • Nateglinide
  • Nebivolol
  • Nebivolol; Valsartan
  • Nortriptyline
  • Orlistat
  • Oxycodone
  • Oxymorphone
  • Ozanimod
  • Paroxetine
  • Perphenazine; Amitriptyline
  • Phendimetrazine
  • Phentermine
  • Phentermine; Topiramate
  • Phosphodiesterase inhibitors
  • Pioglitazone
  • Pramlintide
  • Protriptyline
  • Remifentanil
  • Repaglinide
  • Rosiglitazone
  • Saxagliptin
  • Selective serotonin reuptake inhibitors
  • Selegiline
  • Semaglutide
  • Serotonin norepinephrine reuptake inhibitors
  • Serotonin-Receptor Agonists
  • Sertraline
  • Sibutramine
  • Simvastatin; Sitagliptin
  • Sitagliptin
  • St. John’s Wort, Hypericum perforatum
  • Sufentanil
  • Sulfonylureas
  • Tapentadol
  • Thiazolidinediones
  • Tolazamide
  • Tolbutamide
  • Tramadol
  • Tricyclic antidepressants
  • Trimipramine
  • Triptorelin