Loratadine

Loratadine Brand Names

Alavert | Allergy Relief | Claritin | Claritin Chewable | Claritin Hives Relief | Claritin Liqui-Gel | Claritin RediTab | Claritin-D 24 Hour | Clear-Atadine | Dimetapp Children’s Non-Drowsy Allergy | QlearQuil All Day & All Night Allergy Relief | Tavist ND

What is Loratadine

Loratadine is an oral non-sedating antihistamine (H1-blocker) that is similar in structure to cyproheptadine and azatadine.

Due to poor penetration into the central nervous system (CNS) and a low affinity for CNS histamine H1-receptors, the drug is less likely to cause sedation or other CNS effects compared with traditional, sedating antihistamines.

Unlike astemizole and terfenadine, which are no longer marketed due to arrhythmia risks, loratadine has not been associated with QT prolongation.

Loratadine is used in both adult and pediatric populations for allergic rhinitis and chronic idiopathic urticaria or other allergic symptoms.

Loratadine was first approved by the FDA in April 1993 as a prescription medication.

Loratadine products became approved for non-prescription (OTC) sale in December 2002.

Indications

1. allergic rhinitis
2. chronic idiopathic urticaria
3. exercise-induced bronchospasm prophylaxis
4. perennial allergies
5. pruritus
6. seasonal allergies

For the management of symptoms of seasonal allergies or perennial allergies, including allergic rhinitis

Side Effects

1. abdominal pain
2. alopecia
3. amnesia
4. anaphylactoid reactions
5. angioedema
6. anorexia
7. anxiety
8. appetite stimulation
9. arthralgia
10. asthenia
11. blepharospasm
12. blurred vision
13. breast enlargement
14. bronchospasm
15. chest pain (unspecified)
16. chills
17. confusion
18. conjunctivitis
19. constipation
20. cough
21. depression
22. diarrhea
23. dizziness
24. drowsiness
25. dysgeusia
26. dysmenorrhea
27. dyspepsia
28. dyspnea
29. elevated hepatic enzymes
30. epistaxis
31. erythema multiforme
32. fatigue
33. fever
34. flatulence
35. flushing
36. gastritis
37. headache
38. hemoptysis
39. hepatic necrosis
40. hepatitis
41. hiccups
42. hyperhidrosis
43. hypertension
44. hypertonia
45. hypoesthesia
46. hypotension
47. impotence (erectile dysfunction)
48. infection
49. insomnia
50. irritability
51. jaundice
52. laryngitis
53. libido decrease
54. mastalgia
55. menorrhagia
56. migraine
57. muscle cramps
58. myalgia
59. nasal dryness
60. nausea
61. ocular pain
62. otalgia
63. palpitations
64. paranoia
65. paresthesias
66. peripheral edema
67. pharyngitis
68. photosensitivity
69. polydipsia
70. pruritus
71. purpura
72. rash
73. seizures
74. sinus tachycardia
75. sinusitis
76. sneezing
77. stomatitis
78. supraventricular tachycardia (SVT)
79. syncope
80. thrombocytopenia
81. tinnitus
82. tremor
83. urinary incontinence
84. urinary retention
85. urine discoloration
86. urticaria
87. vaginitis
88. vertigo
89. vomiting
90. weight gain
91. wheezing
92. xerosis
93. xerostomia

Monitoring Parameters

• laboratory monitoring not necessary

Contraindications

• asthma
• breast-feeding
• children
• driving or operating machinery
• geriatric
• hepatic disease
• infants
• neonates
• phenylketonuria
• pregnancy
• renal failure
• renal impairment

Interactions

• Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
• Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
• Acetaminophen; Dextromethorphan; Doxylamine
• Acetaminophen; Diphenhydramine
• Acrivastine; Pseudoephedrine
• Brompheniramine
• Brompheniramine; Carbetapentane; Phenylephrine
• Brompheniramine; Dextromethorphan; Guaifenesin
• Brompheniramine; Dextromethorphan; Phenylephrine
• Brompheniramine; Guaifenesin; Hydrocodone
• Brompheniramine; Hydrocodone; Pseudoephedrine
• Brompheniramine; Pseudoephedrine
• Carbetapentane; Chlorpheniramine
• Carbetapentane; Chlorpheniramine; Phenylephrine
• Carbetapentane; Diphenhydramine; Phenylephrine
• Carbetapentane; Phenylephrine; Pyrilamine
• Carbetapentane; Pyrilamine
• Carbinoxamine
• Carbinoxamine; Dextromethorphan; Pseudoephedrine
• Carbinoxamine; Hydrocodone; Phenylephrine
• Carbinoxamine; Hydrocodone; Pseudoephedrine
• Carbinoxamine; Phenylephrine
• Carbinoxamine; Pseudoephedrine
• Cetirizine
• Cetirizine; Pseudoephedrine
• Chlophedianol; Dexbrompheniramine
• Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
• Chlorcyclizine
• Chlorpheniramine
• Chlorpheniramine; Codeine
• Chlorpheniramine; Dextromethorphan
• Chlorpheniramine; Dextromethorphan; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
• Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Hydrocodone
• Chlorpheniramine; Hydrocodone; Phenylephrine
• Chlorpheniramine; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Phenylephrine
• Chlorpheniramine; Pseudoephedrine
• Clemastine
• Cyclizine
• Cyproheptadine
• Desloratadine
• Desloratadine; Pseudoephedrine
• Dexchlorpheniramine
• Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
• Dextromethorphan; Diphenhydramine; Phenylephrine
• Dimenhydrinate
• Diphenhydramine
• Diphenhydramine; Hydrocodone; Phenylephrine
• Diphenhydramine; Ibuprofen
• Diphenhydramine; Naproxen
• Diphenhydramine; Phenylephrine
• Doxylamine
• Doxylamine; Pyridoxine
• Fexofenadine
• Fexofenadine; Pseudoephedrine
• Heparin
• Hydroxyzine
• Levocetirizine
• Meclizine
• Sedating H1-blockers
• Sincalide
• Triprolidine