Lisdexamfetamine

Lisdexamfetamine Brand Name– Vyvanse

What is Lisdexamfetamine

Lisdexamfetamine is a prodrug of dextroamphetamine, a centrally acting stimulant indicated for treatment of Attention-Deficit Hyperactivity Disorder (ADHD) in adults and pediatric patients 6 years and older and for treating binge-eating disorder (BED) in adults.

Lisdexamfetamine and other stimulants are considered first-line therapy in the treatment of Attention-Deficit Hyperactivity Disorder (ADHD), and are best utilized as part of a comprehensive approach including psychological, educational, and/or social interventions.

Drug therapy is not intended for use in children with symptoms resulting from environmental factors or other primary psychiatric disorders.

Efficacy for moderate to severe binge-eating disorder (BED) in adults up to 55 years of age was evidenced by the primary outcome of a greater reduction in the reported number of binge-eating days per week versus placebo.

Lisdexamfetamine is not indicated for or recommended for weight loss or the treatment of obesity. Use of other sympathomimetic drugs for weight loss has been associated with serious cardiovascular adverse events.

As with other amphetamines, assess all patients for risk for substance abuse prior to treatment, and monitor treated patients for signs and symptoms of abuse and dependence during therapy.

Lisdexamfetamine was initially FDA-approved in 2007

Indications

  • attention-deficit hyperactivity disorder (ADHD)
  • binge-eating disorder

For the treatment of attention-deficit hyperactivity disorder (ADHD)

Side Effects

  1. abdominal pain
  2. agitation
  3. alopecia
  4. anaphylactoid reactions
  5. angioedema
  6. anorexia
  7. anxiety
  8. arrhythmia exacerbation
  9. blurred vision
  10. bradycardia
  11. cardiomyopathy
  12. chest pain (unspecified)
  13. confusion
  14. constipation
  15. delirium
  16. depression
  17. diarrhea
  18. diplopia
  19. dizziness
  20. drowsiness
  21. dysgeusia
  22. dyskinesia
  23. dyspepsia
  24. dysphoria
  25. dyspnea
  26. emotional lability
  27. euphoria
  28. fatigue
  29. fever
  30. growth inhibition
  31. hallucinations
  32. headache
  33. hepatitis
  34. hostility
  35. hyperhidrosis
  36. hyperreflexia
  37. hypertension
  38. hyperthermia
  39. hypotension
  40. impotence (erectile dysfunction)
  41. infection
  42. insomnia
  43. irritability
  44. libido decrease
  45. libido increase
  46. mania
  47. mydriasis
  48. myocardial infarction
  49. nausea
  50. nightmares
  51. ocular hypertension
  52. palpitations
  53. paranoia
  54. paresthesias
  55. peripheral vasoconstriction
  56. photosensitivity
  57. physiological dependence
  58. priapism
  59. pruritus
  60. psychological dependence
  61. psychosis
  62. rash
  63. restlessness
  64. rhabdomyolysis
  65. seizures
  66. serotonin syndrome
  67. sinus tachycardia
  68. skin ulcer
  69. Stevens-Johnson syndrome
  70. stroke
  71. supranormalization
  72. syncope
  73. tachypnea
  74. teeth grinding (bruxism)
  75. tolerance
  76. Tourette’s syndrome
  77. toxic epidermal necrolysis
  78. tremor
  79. urticaria
  80. visual impairment
  81. vomiting
  82. weight loss
  83. withdrawal
  84. xerostomia

Monitoring Parameters

  • blood pressure
  • growth rate
  • heart rate
  • serum creatinine/BUN
  • weight

Contraindications

  • abrupt discontinuation
  • acute myocardial infarction
  • alcoholism
  • anorexia nervosa
  • aortic stenosis
  • arteriosclerosis
  • bipolar disorder
  • breast-feeding
  • bulimia nervosa
  • cardiac arrhythmias
  • cardiac disease
  • cardiomyopathy
  • congenital heart disease
  • coronary artery disease
  • depression
  • driving or operating machinery
  • geriatric
  • glaucoma
  • growth inhibition
  • heart failure
  • hepatic disease
  • hypercortisolism
  • hypertension
  • hyperthyroidism
  • infants
  • labor
  • mania
  • MAOI therapy
  • myocardial infarction
  • neonates
  • obesity treatment
  • obstetric delivery
  • peripheral vascular disease
  • pregnancy
  • premature labor
  • priapism
  • prosthetic heart valves
  • psychosis
  • radiographic contrast administration
  • Raynaud’s phenomenon
  • renal failure
  • renal impairment
  • schizophrenia
  • seizure disorder
  • seizures
  • stroke
  • substance abuse
  • suicidal ideation
  • surgery
  • syncope
  • tachycardia
  • thyrotoxicosis
  • tics
  • Tourette’s syndrome
  • valvular heart disease
  • ventricular arrhythmias
  • ventricular dysfunction
  • visual disturbance

Interactions

  • Acarbose
  • Acebutolol
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Codeine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Tramadol
  • Acetazolamide
  • Albiglutide
  • Albuterol
  • Albuterol; Ipratropium
  • Alfentanil
  • Aliskiren
  • Aliskiren; Amlodipine
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Aliskiren; Valsartan
  • Alkalinizing Agents
  • Alogliptin; Metformin
  • Alogliptin; Pioglitazone
  • Alpha-glucosidase Inhibitors
  • Aluminum Hydroxide
  • Aluminum Hydroxide; Magnesium Carbonate
  • Aluminum Hydroxide; Magnesium Hydroxide
  • Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
  • Aluminum Hydroxide; Magnesium Trisilicate
  • Ambrisentan
  • Amifampridine
  • Amlodipine
  • Amlodipine; Atorvastatin
  • Amlodipine; Benazepril
  • Amlodipine; Celecoxib
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
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  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Oxycodone
  • Atenolol
  • Atenolol; Chlorthalidone
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  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
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  • Brompheniramine; Hydrocodone; Pseudoephedrine
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  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorthalidone; Clonidine
  • Cinacalcet
  • Citalopram
  • Citric Acid; Potassium Citrate
  • Citric Acid; Potassium Citrate; Sodium Citrate
  • Citric Acid; Sodium Citrate
  • Clevidipine
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  • Clonazepam
  • Clonidine
  • Clorazepate
  • Cocaine
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
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  • Colchicine
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  • Dorzolamide; Timolol
  • Doxazosin
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  • Duloxetine
  • Dyphylline
  • Dyphylline; Guaifenesin
  • Empagliflozin
  • Empagliflozin; Linagliptin
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • Enalapril; Felodipine
  • Eplerenone
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  • Ergonovine
  • Ergot alkaloids
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  • Ertugliflozin; Metformin
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  • Felodipine
  • Fenfluramine
  • Fentanyl
  • Fluoxetine
  • Fluoxetine; Olanzapine
  • Fluticasone; Salmeterol
  • Fluticasone; Umeclidinium; Vilanterol
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  • Fluvoxamine
  • food
  • Gabapentin
  • General anesthetics
  • Glimepiride; Pioglitazone
  • Glimepiride; Rosiglitazone
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  • Green Tea
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  • Homatropine; Hydrocodone
  • Hydantoins
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydromorphone
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Ibritumomab Tiuxetan
  • Ibuprofen; Oxycodone
  • Iloprost
  • Incretin Mimetics
  • Indacaterol
  • Indacaterol; Glycopyrrolate
  • Indapamide
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  • Insulins
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  • Levodopa
  • Levomilnacipran
  • Levorphanol
  • Levothyroxine
  • Levothyroxine; Liothyronine (Porcine)
  • Levothyroxine; Liothyronine (Synthetic)
  • Linagliptin; Metformin
  • Linezolid
  • Liothyronine
  • Liraglutide
  • Lithium
  • Lixisenatide
  • Loop diuretics
  • Lopinavir; Ritonavir
  • Lorazepam
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  • Lurasidone
  • Macitentan
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  • Maprotiline
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  • Meglitinides
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  • Meperidine; Promethazine
  • Mephobarbital
  • Metformin
  • Metformin; Pioglitazone
  • Metformin; Repaglinide
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  • Metformin; Saxagliptin
  • Metformin; Sitagliptin
  • Methadone
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  • Methenamine
  • Methenamine; Sodium Acid Phosphate
  • Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
  • Methohexital
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  • Morphine
  • Morphine; Naltrexone
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  • Nalbuphine
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  • Nicardipine
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  • Nimodipine
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  • Nitrates
  • Non-Ionic Contrast Media
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  • Oxycodone
  • Oxymorphone
  • Ozanimod
  • Paroxetine
  • Penbutolol
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  • Perampanel
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  • Phenoxybenzamine
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  • Phentermine; Topiramate
  • Phentolamine
  • Pindolol
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  • Potassium Bicarbonate
  • Potassium Chloride
  • Potassium Citrate
  • Potassium-sparing diuretics
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  • Vasodilators
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  • Vigabatrin
  • Vilazodone
  • Vortioxetine
  • Ziprasidone
  • Zonisamide
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