Levobetaxolol

Levobetaxolol Brand Name– Betaxon

What is Levobetaxolol

NOTE: This drug is discontinued in the U.S.

Levobetaxolol is an ophthalmic suspension which is applied twice daily for the treatment of chronic open-angle glaucoma or ocular hypertension.

Levobetaxolol (S-isomer) is the more active enantiomer of racemic betaxolol, a potent and highly selective beta-1 adrenergic antagonist with weak beta-2-blocking activity.

Levobetaxolol and betaxolol are the preferred ophthalmic beta-blockers in patients with bronchospastic pulmonary disease due to their selectivity for the beta-1 receptor. In comparison, levobunol, carteolol, and timolol are nonselective beta-blockers.

Levobetaxolol does not have intrinsic sympathomimetic or significant membrane-stabilizing activities.

Levobetaxolol was approved by the FDA on February 29, 2000.

Indications

  • glaucoma
  • ocular hypertension

For the treatment of chronic open-angle glaucoma or ocular hypertension to reduce intraocular pressure

NOTE: Beta-blockers are generally less effective in treating angle-closure glaucoma than open-angle glaucoma. In treating angle-closure glaucoma, the immediate goal is to re-open the angle using a miotic agent to constrict the pupil. When using levobetaxolol to treat ocular hypertension in patients with angle-closure glaucoma, it should be used with a miotic agent and not alone.

Side Effects

  1. alopecia
  2. anxiety
  3. AV block
  4. blurred vision
  5. bradycardia
  6. bronchospasm
  7. cardiac arrest
  8. cataracts
  9. constipation
  10. contact dermatitis
  11. cystitis
  12. depression
  13. diabetes mellitus
  14. dizziness
  15. dysgeusia
  16. dyspnea
  17. fatigue
  18. gout
  19. hallucinations
  20. headache
  21. heart failure
  22. hypercholesterolemia
  23. hyperlipidemia
  24. hypertension
  25. hypertonia
  26. hypotension
  27. hypothyroidism
  28. infection
  29. myocardial infarction
  30. nightmares
  31. ocular irritation
  32. pharyngitis
  33. psoriasis
  34. rhinitis
  35. sinus tachycardia
  36. sinusitis
  37. tinnitus
  38. vertigo

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • acute bronchospasm
  • asthma
  • atopy
  • AV block
  • bradycardia
  • breast-feeding
  • bronchitis
  • cardiac disease
  • cardiogenic shock
  • cerebrovascular disease
  • children
  • chronic obstructive pulmonary disease (COPD)
  • contact lenses
  • coronary artery disease
  • depression
  • diabetes mellitus
  • emphysema
  • geriatric
  • heart failure
  • hyperthyroidism
  • hypotension
  • myasthenia gravis
  • peripheral vascular disease
  • pheochromocytoma
  • pregnancy
  • pulmonary disease
  • Raynaud’s phenomenon
  • sick sinus syndrome
  • surgery
  • thyroid disease
  • thyrotoxicosis
  • vasospastic angina
  • ventricular dysfunction

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