Lefamulin Brand Name– Xenleta
What is Lefamulin
Lefamulin is a first-in-class oral and injectable pleuromutilin antibiotic indicated for the treatment of community-acquired pneumonia.
Lefamulin may maintain activity against some bacterial isolates that may be resistant to other antibiotic classes.
Lefamulin may cause QT prolongation, and the oral formulation is contraindicated for use with CYP3A4 substrates that also prolong the QT interval.
Based on animal data, lefamulin may cause fetal harm when administered during pregnancy; therefore, effective contraception use is recommended for women of reproductive potential.
Indications
- Chlamydophila pneumoniae
- community-acquired pneumonia
- Haemophilus influenzae (beta-lactamase negative)
- Haemophilus influenzae (beta-lactamase positive)
- Haemophilus parainfluenzae
- Legionella pneumophila
- Moraxella catarrhalis
- Mycoplasma pneumoniae
- Staphylococcus aureus (MRSA)
- Staphylococcus aureus (MSSA)
- Streptococcus agalactiae (group B streptococci)
- Streptococcus anginosus
- Streptococcus mitis
- Streptococcus pneumoniae
- Streptococcus pyogenes (group A beta-hemolytic streptococci)
- Streptococcus salivarius
Side Effects
- abdominal pain
- anemia
- anxiety
- atrial fibrillation
- candidiasis
- constipation
- diarrhea
- drowsiness
- dyspepsia
- elevated hepatic enzymes
- gastritis
- headache
- hypokalemia
- injection site reaction
- insomnia
- nausea
- palpitations
- phlebitis
- pseudomembranous colitis
- QT prolongation
- superinfection
- thrombocytopenia
- urinary retention
- vomiting
Monitoring Parameters
- pregnancy testing
Contraindications
- apheresis
- AV block
- bradycardia
- breast-feeding
- cardiomyopathy
- celiac disease
- contraception requirements
- dialysis
- diarrhea
- females
- fever
- geriatric
- heart failure
- hepatic disease
- human immunodeficiency virus (HIV) infection
- hyperparathyroidism
- hypocalcemia
- hypokalemia
- hypomagnesemia
- hypothermia
- hypothyroidism
- long QT syndrome
- myocardial infarction
- pheochromocytoma
- pregnancy
- pregnancy testing
- pseudomembranous colitis
- QT prolongation
- renal failure
- reproductive risk
- rheumatoid arthritis
- sickle cell disease
- sleep deprivation
- stroke
- systemic lupus erythematosus (SLE)
- torsade de pointes
- ventricular arrhythmias
Interactions
- Abemaciclib
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- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
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