Lefamulin

Lefamulin Brand Name– Xenleta

What is Lefamulin

Lefamulin is a first-in-class oral and injectable pleuromutilin antibiotic indicated for the treatment of community-acquired pneumonia.

Lefamulin may maintain activity against some bacterial isolates that may be resistant to other antibiotic classes.

Lefamulin may cause QT prolongation, and the oral formulation is contraindicated for use with CYP3A4 substrates that also prolong the QT interval.

Based on animal data, lefamulin may cause fetal harm when administered during pregnancy; therefore, effective contraception use is recommended for women of reproductive potential.

Indications

  1. Chlamydophila pneumoniae
  2. community-acquired pneumonia
  3. Haemophilus influenzae (beta-lactamase negative)
  4. Haemophilus influenzae (beta-lactamase positive)
  5. Haemophilus parainfluenzae
  6. Legionella pneumophila
  7. Moraxella catarrhalis
  8. Mycoplasma pneumoniae
  9. Staphylococcus aureus (MRSA)
  10. Staphylococcus aureus (MSSA)
  11. Streptococcus agalactiae (group B streptococci)
  12. Streptococcus anginosus
  13. Streptococcus mitis
  14. Streptococcus pneumoniae
  15. Streptococcus pyogenes (group A beta-hemolytic streptococci)
  16. Streptococcus salivarius

Side Effects

  1. abdominal pain
  2. anemia
  3. anxiety
  4. atrial fibrillation
  5. candidiasis
  6. constipation
  7. diarrhea
  8. drowsiness
  9. dyspepsia
  10. elevated hepatic enzymes
  11. gastritis
  12. headache
  13. hypokalemia
  14. injection site reaction
  15. insomnia
  16. nausea
  17. palpitations
  18. phlebitis
  19. pseudomembranous colitis
  20. QT prolongation
  21. superinfection
  22. thrombocytopenia
  23. urinary retention
  24. vomiting

Monitoring Parameters

  • pregnancy testing

Contraindications

  • apheresis
  • AV block
  • bradycardia
  • breast-feeding
  • cardiomyopathy
  • celiac disease
  • contraception requirements
  • dialysis
  • diarrhea
  • females
  • fever
  • geriatric
  • heart failure
  • hepatic disease
  • human immunodeficiency virus (HIV) infection
  • hyperparathyroidism
  • hypocalcemia
  • hypokalemia
  • hypomagnesemia
  • hypothermia
  • hypothyroidism
  • long QT syndrome
  • myocardial infarction
  • pheochromocytoma
  • pregnancy
  • pregnancy testing
  • pseudomembranous colitis
  • QT prolongation
  • renal failure
  • reproductive risk
  • rheumatoid arthritis
  • sickle cell disease
  • sleep deprivation
  • stroke
  • systemic lupus erythematosus (SLE)
  • torsade de pointes
  • ventricular arrhythmias

Interactions

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