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What is Latanoprost Timolol
Latanoprost 0.005%, a prostaglandin analog, is combined with timolol 0.5%, a non-specific beta-blocker, in an ophthalmic product (Xalcom™) for the reduction of intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension, who are insufficiently responsive to beta-blockers.
This product offers the advantage of once daily ocular administration of beta-blocker and prostaglandin combination therapy.
The combination of latanoprost and timolol results in additive IOP-lowering effects.
Iris pigmentation may occur during long-term therapy with latanoprost. Xalcom™ received an approvable letter (requiring further study) by the FDA on October 2, 2001; additional studies may take up to 2 years to complete.
The European product (Xalacom) was introduced in October 2001.
Indications
- glaucoma
- ocular hypertension
For the reduction of elevated intraocular pressure in patients with open-angle glaucoma† or ocular hypertension† who are insufficiently responsive to other intraocular pressure (IOP) lowering medications including beta-blockers and prostaglandins
Side Effects
- angina
- angioedema
- asthenia
- AV block
- blepharedema
- blepharitis
- blurred vision
- bradycardia
- bronchospasm
- cardiac arrest
- conjunctival hyperemia
- conjunctivitis
- depression
- diplopia
- dizziness
- dyspnea
- fatigue
- foreign body sensation
- hallucinations
- headache
- heart failure
- hypertension
- hypertrichosis
- hypotension
- iridal discoloration
- iritis
- keratitis
- keratopathy
- lacrimation
- macular edema
- nightmares
- ocular inflammation
- ocular irritation
- ocular pain
- ocular pruritus
- photophobia
- ptosis
- rash
- sinus tachycardia
- syncope
- toxic epidermal necrolysis
- urticaria
- uveitis
- visual impairment
- xerophthalmia
Monitoring Parameters
- intraocular pressure
- ophthalmologic exam
Contraindications
- acute bronchospasm
- aphakia
- asthma
- atopy
- AV block
- bradycardia
- breast-feeding
- bronchitis
- cardiac disease
- cardiogenic shock
- cerebrovascular disease
- children
- chronic obstructive pulmonary disease (COPD)
- closed-angle glaucoma
- contact lenses
- corneal abrasion
- coronary artery disease
- depression
- diabetes mellitus
- emphysema
- geriatric
- heart failure
- hepatic disease
- hyperthyroidism
- hypotension
- iritis
- keratitis
- myasthenia gravis
- ocular infection
- ocular surgery
- ocular trauma
- peripheral vascular disease
- pheochromocytoma
- pregnancy
- pulmonary disease
- Raynaud’s phenomenon
- renal disease
- renal failure
- renal impairment
- sick sinus syndrome
- stroke
- sunlight (UV) exposure
- surgery
- thyroid disease
- thyrotoxicosis
- uveitis
- vasospastic angina
- ventricular dysfunction
Interactions
No information is available regarding drug interactions associated with Latanoprost Timolol
