Latanoprost Timolol

What is Latanoprost Timolol

Latanoprost 0.005%, a prostaglandin analog, is combined with timolol 0.5%, a non-specific beta-blocker, in an ophthalmic product (Xalcom™) for the reduction of intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension, who are insufficiently responsive to beta-blockers.

This product offers the advantage of once daily ocular administration of beta-blocker and prostaglandin combination therapy.

The combination of latanoprost and timolol results in additive IOP-lowering effects.

Iris pigmentation may occur during long-term therapy with latanoprost. Xalcom™ received an approvable letter (requiring further study) by the FDA on October 2, 2001; additional studies may take up to 2 years to complete.

The European product (Xalacom) was introduced in October 2001.

Indications

  • glaucoma
  • ocular hypertension

For the reduction of elevated intraocular pressure in patients with open-angle glaucoma† or ocular hypertension† who are insufficiently responsive to other intraocular pressure (IOP) lowering medications including beta-blockers and prostaglandins

Side Effects

  1. angina
  2. angioedema
  3. asthenia
  4. AV block
  5. blepharedema
  6. blepharitis
  7. blurred vision
  8. bradycardia
  9. bronchospasm
  10. cardiac arrest
  11. conjunctival hyperemia
  12. conjunctivitis
  13. depression
  14. diplopia
  15. dizziness
  16. dyspnea
  17. fatigue
  18. foreign body sensation
  19. hallucinations
  20. headache
  21. heart failure
  22. hypertension
  23. hypertrichosis
  24. hypotension
  25. iridal discoloration
  26. iritis
  27. keratitis
  28. keratopathy
  29. lacrimation
  30. macular edema
  31. nightmares
  32. ocular inflammation
  33. ocular irritation
  34. ocular pain
  35. ocular pruritus
  36. photophobia
  37. ptosis
  38. rash
  39. sinus tachycardia
  40. syncope
  41. toxic epidermal necrolysis
  42. urticaria
  43. uveitis
  44. visual impairment
  45. xerophthalmia

Monitoring Parameters

  • intraocular pressure
  • ophthalmologic exam

Contraindications

  • acute bronchospasm
  • aphakia
  • asthma
  • atopy
  • AV block
  • bradycardia
  • breast-feeding
  • bronchitis
  • cardiac disease
  • cardiogenic shock
  • cerebrovascular disease
  • children
  • chronic obstructive pulmonary disease (COPD)
  • closed-angle glaucoma
  • contact lenses
  • corneal abrasion
  • coronary artery disease
  • depression
  • diabetes mellitus
  • emphysema
  • geriatric
  • heart failure
  • hepatic disease
  • hyperthyroidism
  • hypotension
  • iritis
  • keratitis
  • myasthenia gravis
  • ocular infection
  • ocular surgery
  • ocular trauma
  • peripheral vascular disease
  • pheochromocytoma
  • pregnancy
  • pulmonary disease
  • Raynaud’s phenomenon
  • renal disease
  • renal failure
  • renal impairment
  • sick sinus syndrome
  • stroke
  • sunlight (UV) exposure
  • surgery
  • thyroid disease
  • thyrotoxicosis
  • uveitis
  • vasospastic angina
  • ventricular dysfunction

Interactions

No information is available regarding drug interactions associated with Latanoprost Timolol

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