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Itraconazole Brand Names
ONMEL | Sporanox | TOLSURA
What is Itraconazole
Itraconazole is an oral azole antifungal agent indicated for the treatment of pulmonary and extrapulmonary blastomycosis, histoplasmosis, including chronic cavitary pulmonary disease and disseminated, nonmeningeal disease, pulmonary and extrapulmonary aspergillosis in patients who are intolerant or refractory to amphotericin B, onychomycosis of the toenail or fingernail in non-immunocompromised patients, and oropharyngeal or esophageal candidiasis. FDA-approved indications vary by dosage form, and dosage forms are not interchangeable.
Itraconazole is closely related to ketoconazole but appears to have fewer adverse effects.
Itraconazole is active against many of the same fungi as ketoconazole and fluconazole but has greater activity against Aspergillus.
Indications
- allergic bronchopulmonary aspergillosis
- aspergillosis
- aspergillosis prophylaxis
- Aspergillus flavus
- Aspergillus fumigatus
- Aspergillus niger
- Aspergillus terreus
- Aspergillus ustus
- Blastomyces dermatitidis
- blastomycosis
- blastomycosis prophylaxis
- Candida albicans
- Candida glabrata
- Candida guilliermondii
- Candida kefyr
- Candida krusei
- Candida parapsilosis
- Candida pseudotropicalis
- Candida sp.
- Candida stellatoidea
- Candida tropicalis
- candidiasis prophylaxis
- Coccidioides immitis
- coccidioidomycosis
- coccidioidomycosis prophylaxis
- cryptococcosis prophylaxis
- Cryptococcus neoformans
- esophageal candidiasis
- fungal keratitis
- Histoplasma capsulatum
- Histoplasma duboisii
- histoplasmosis
- histoplasmosis prophylaxis
- Malassezia furfur
- meningitis
- microsporidiosis
- onychomycosis
- oropharyngeal candidiasis (thrush)
- seborrheic dermatitis
- Sporothrix schenckii
- sporotrichosis
- sporotrichosis prophylaxis
- Talaromyces marneffei
- talaromycosis
- talaromycosis prophylaxis
- tinea capitis
- tinea corporis
- tinea cruris
- tinea manuum
- tinea pedis
- tinea versicolor
- Trichophyton mentagrophytes
- Trichophyton rubrum
- Trichophyton sp.
- vulvovaginal candidiasis
Side Effects
- abdominal pain
- acute generalized exanthematous pustulosis (AGEP)
- adrenocortical insufficiency
- alopecia
- anaphylactoid reactions
- angioedema
- anorexia
- anxiety
- appetite stimulation
- arthralgia
- asthenia
- back pain
- blurred vision
- bradycardia
- chest pain (unspecified)
- chills
- confusion
- constipation
- cough
- cystitis
- dehydration
- depression
- diarrhea
- diplopia
- dizziness
- drowsiness
- dysgeusia
- dyspepsia
- dysphagia
- dysphonia
- dyspnea
- edema
- elevated hepatic enzymes
- erythema multiforme
- exfoliative dermatitis
- fatigue
- fever
- flatulence
- gastritis
- gingivitis
- gynecomastia
- headache
- hearing loss
- heart failure
- hematuria
- hemorrhoids
- hepatic failure
- hepatitis
- hot flashes
- hyperbilirubinemia
- hyperglycemia
- hyperhidrosis
- hyperkalemia
- hypertension
- hypertriglyceridemia
- hypocalcemia
- hypoesthesia
- hypokalemia
- hypomagnesemia
- hypophosphatemia
- hypotension
- impotence (erectile dysfunction)
- infection
- insomnia
- jaundice
- leukopenia
- libido decrease
- malaise
- menstrual irregularity
- myalgia
- nausea
- neutropenia
- nightmares
- orthostatic hypotension
- pancreatitis
- paresthesias
- peripheral edema
- peripheral neuropathy
- pharyngitis
- photosensitivity
- pruritus
- pulmonary edema
- QT prolongation
- rash
- rhinitis
- secondary malignancy
- serum sickness
- sinus tachycardia
- sinusitis
- Stevens-Johnson syndrome
- stomatitis
- teratogenesis
- thrombocytopenia
- tinnitus
- torsade de pointes
- toxic epidermal necrolysis
- tremor
- urinary incontinence
- urticaria
- vasculitis
- vertigo
- visual impairment
- vomiting
- weight loss
Monitoring Parameters
- LFTs
Contraindications
- achlorhydria
- apheresis
- AV block
- azole antifungals hypersensitivity
- bradycardia
- breast-feeding
- cardiomyopathy
- celiac disease
- children
- chronic obstructive pulmonary disease (COPD)
- contraception requirements
- coronary artery disease
- cystic fibrosis
- dialysis
- driving or operating machinery
- females
- fever
- geriatric
- heart failure
- hepatic disease
- hepatotoxicity
- human immunodeficiency virus (HIV) infection
- hyperparathyroidism
- hypocalcemia
- hypochlorhydria
- hypokalemia
- hypomagnesemia
- hypothermia
- hypothyroidism
- infants
- itraconazole coadministration with other drugs
- long QT syndrome
- myocardial infarction
- neonates
- neutropenia
- pheochromocytoma
- pregnancy
- pulmonary disease
- pulmonary edema
- QT prolongation
- reproductive risk
- rheumatoid arthritis
- sickle cell disease
- sleep deprivation
- stroke
- systemic lupus erythematosus (SLE)
- valvular heart disease
- ventricular arrhythmias
- ventricular dysfunction
Interactions
- Abacavir; Dolutegravir; Lamivudine
- Abemaciclib
- Acalabrutinib
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Codeine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Propoxyphene
- Aclidinium; Formoterol
- Ado-Trastuzumab emtansine
- Afatinib
- Albuterol
- Albuterol; Ipratropium
- Alfentanil
- Alfuzosin
- Aliskiren
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Aliskiren; Valsartan
- Almotriptan
- Alogliptin; Pioglitazone
- Alosetron
- Alpelisib
- Alprazolam
- Alvimopan
- Amiodarone
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amphotericin B
- Amphotericin B cholesteryl sulfate complex (ABCD)
- Amphotericin B lipid complex (ABLC)
- Amphotericin B liposomal (LAmB)
- Amprenavir
- Anagrelide
- Antacids
- Apalutamide
- Apixaban
- Apomorphine
- Aprepitant, Fosaprepitant
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- Armodafinil
- Arsenic Trioxide
- Artemether; Lumefantrine
- Asenapine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Oxycodone
- Atazanavir
- Atazanavir; Cobicistat
- Atomoxetine
- Atorvastatin
- Atorvastatin; Ezetimibe
- Atropine
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Atropine; Edrophonium
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Avanafil
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- Cevimeline
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- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
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- Daclatasvir
- Dapagliflozin; Saxagliptin
- Darifenacin
- Darolutamide
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- Dasatinib
- Deflazacort
- Degarelix
- Delavirdine
- Desflurane
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- Deutetrabenazine
- Dexamethasone
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- Diazepam
- Dichlorphenamide
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- Didanosine, ddI
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- Digoxin
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- Docetaxel
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- Donepezil
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- Doxorubicin
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- Elagolix
- Elagolix; Estradiol; Norethindrone acetate
- Elbasvir; Grazoprevir
- Eletriptan
- Elexacaftor; tezacaftor; ivacaftor
- Eliglustat
- Elvitegravir
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- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Emtricitabine; Tenofovir disoproxil fumarate
- Enalapril; Felodipine
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- Eszopiclone
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Ethosuximide
- Etonogestrel
- Etravirine
- Everolimus
- Ezetimibe; Simvastatin
- Ezogabine
- Famotidine
- Famotidine; Ibuprofen
- Fedratinib
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- Fentanyl
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- Fingolimod
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- Flibanserin
- Fluconazole
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluphenazine
- Flurazepam
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- Fluticasone; Salmeterol
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- Fluticasone; Vilanterol
- Fluvoxamine
- food
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- Gefitinib
- Gemifloxacin
- Gemtuzumab Ozogamicin
- Gilteritinib
- Glasdegib
- Glecaprevir; Pibrentasvir
- Glimepiride; Pioglitazone
- Glycopyrrolate
- Glycopyrrolate; Formoterol
- Goserelin
- Granisetron
- grapefruit juice
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guanfacine
- H2-blockers
- Halofantrine
- Halogenated Anesthetics
- Haloperidol
- Halothane
- Histrelin
- Homatropine; Hydrocodone
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydroxychloroquine
- Hydroxyprogesterone
- Hydroxyzine
- Hyoscyamine
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibrutinib
- Ibuprofen; Oxycodone
- Ibutilide
- Idelalisib
- Ifosfamide
- Iloperidone
- Imatinib
- Imipramine
- Indacaterol
- Indacaterol; Glycopyrrolate
- Indinavir
- Inotuzumab Ozogamicin
- Irinotecan
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- Isavuconazonium
- Isoflurane
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- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
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- Isradipine
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- Ivabradine
- Ivacaftor
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- Ixabepilone
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- Larotrectinib
- Ledipasvir; Sofosbuvir
- Lefamulin
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- Lemborexant
- Lenvatinib
- Leuprolide
- Leuprolide; Norethindrone
- Levalbuterol
- Levobupivacaine
- Levofloxacin
- Levomilnacipran
- Lidocaine
- Lidocaine; Prilocaine
- Lithium
- Lofexidine
- Lomitapide
- Loperamide
- Loperamide; Simethicone
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- Lorlatinib
- Lovastatin
- Lovastatin; Niacin
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- Lumacaftor; Ivacaftor
- Lumateperone
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- Lurbinectedin
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- Maprotiline
- Maraviroc
- Medroxyprogesterone
- Mefloquine
- Meloxicam
- Mepenzolate
- Meperidine; Promethazine
- Metaproterenol
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Saxagliptin
- Methadone
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methotrexate
- Methscopolamine
- Methylergonovine
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- Metronidazole
- Micafungin
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- Nadolol
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- Nevirapine
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- Nicardipine
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- Nimodipine
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- Olanzapine
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