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Isradipine Brand Names- DynaCirc | DynaCirc CR
What is Isradipine
Isradipine is a calcium-channel blocking agent of the dihydropyridine class similar to nifedipine, amlodipine, and felodipine.
On a milligram-per-milligram basis, isradipine is the most potent drug of this class. Currently, isradipine is approved for the treatment of hypertension. Isradipine is longer acting than regular-release nifedipine but has a shorter duration of action than amlodipine.
Unlike with other dihydropyridines, however, chronic therapy with isradipine does not cause increases in heart rate.
It was approved by the FDA in December 1990 for the treatment of hypertension.
Indications
- angina
- hypertension
For the treatment of hypertension
Side Effects
- abdominal pain
- angina
- angioedema
- asthenia
- atrial fibrillation
- constipation
- diarrhea
- dizziness
- dyspnea
- elevated hepatic enzymes
- fatigue
- flushing
- gynecomastia
- headache
- heart failure
- hypotension
- impotence (erectile dysfunction)
- increased urinary frequency
- leukopenia
- libido decrease
- myocardial infarction
- nausea
- palpitations
- paresthesias
- peripheral edema
- peripheral vasodilation
- sinus tachycardia
- stroke
- syncope
- ventricular fibrillation
- vomiting
- weakness
Monitoring Parameters
- blood pressure
- heart rate
Contraindications
- acute myocardial infarction
- bradycardia
- breast-feeding
- cardiogenic shock
- children
- dihydropyridine hypersensitivity
- gastroesophageal reflux disease (GERD)
- geriatric
- heart failure
- hepatic disease
- hiatal hernia
- hypotension
- infants
- neonates
- pregnancy
- renal disease
- ventricular dysfunction
Interactions
- Acebutolol
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Pseudoephedrine
- Acrivastine; Pseudoephedrine
- Aldesleukin, IL-2
- Alemtuzumab
- Alfentanil
- Alfuzosin
- Alprostadil
- Amifostine
- Aminolevulinic Acid
- Amiodarone
- Amlodipine; Celecoxib
- Amobarbital
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amphetamine; Dextroamphetamine Salts
- Amprenavir
- Amyl Nitrite
- Apalutamide
- Apomorphine
- Apraclonidine
- Aprepitant, Fosaprepitant
- Aripiprazole
- Asenapine
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Atazanavir
- Atazanavir; Cobicistat
- Atenolol
- Atenolol; Chlorthalidone
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Baclofen
- Barbiturates
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Bendroflumethiazide; Nadolol
- Benzonatate
- Benzphetamine
- Beta-blockers
- Betaxolol
- Bisoprolol
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Boceprevir
- Bortezomib
- Bosentan
- Brimonidine; Timolol
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Dextromethorphan; Phenylephrine
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Butabarbital
- Cabergoline
- Carbamazepine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbidopa; Levodopa
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Cariprazine
- Carteolol
- Carvedilol
- Celecoxib
- Cenobamate
- Ceritinib
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chlophedianol; Guaifenesin; Phenylephrine
- Chloroprocaine
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Cimetidine
- Ciprofloxacin
- Clarithromycin
- Clozapine
- Co-Enzyme Q10, Ubiquinone
- Cobicistat
- Cocaine
- Codeine; Phenylephrine; Promethazine
- Conivaptan
- Crizotinib
- Dalfopristin; Quinupristin
- Danazol
- Dantrolene
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Delavirdine
- Desloratadine; Pseudoephedrine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmedetomidine
- Dexmethylphenidate
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Dextromethorphan; Quinidine
- Diazoxide
- Diclofenac
- Diclofenac; Misoprostol
- Diethylpropion
- Diflunisal
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Diphenhydramine; Phenylephrine
- Dorzolamide; Timolol
- Dronedarone
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Duloxetine
- Dutasteride; Tamsulosin
- Duvelisib
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elbasvir; Grazoprevir
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Empagliflozin
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Enflurane
- Enzalutamide
- Ephedrine
- Epirubicin
- Eplerenone
- Epoprostenol
- Ergonovine
- Erythromycin
- Erythromycin; Sulfisoxazole
- Esmolol
- Esomeprazole; Naproxen
- Estradiol
- Estradiol Cypionate; Medroxyprogesterone
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Etodolac
- Etomidate
- Everolimus
- Famotidine; Ibuprofen
- Fedratinib
- Fenoprofen
- Fentanyl
- Fexofenadine; Pseudoephedrine
- Fish Oil, Omega-3 Fatty Acids (Dietary Supplements)
- Fluconazole
- Fluoxetine
- Fluoxetine; Olanzapine
- Flurbiprofen
- Fluvoxamine
- Fosamprenavir
- Fospropofol
- Fostamatinib
- General anesthetics
- Ginkgo, Ginkgo biloba
- Ginseng, Panax ginseng
- grapefruit juice
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Phenylephrine
- Guaifenesin; Pseudoephedrine
- Haloperidol
- Halothane
- Hydantoins
- Hydralazine; Isosorbide Dinitrate, ISDN
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Idelalisib
- Iloperidone
- Iloprost
- Imatinib
- Indinavir
- Indomethacin
- Intravenous Lipid Emulsions
- Isavuconazonium
- Isocarboxazid
- Isoflurane
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Isoproterenol
- Isosorbide Dinitrate, ISDN
- Isosorbide Mononitrate
- Itraconazole
- Ketamine
- Ketoconazole
- Ketoprofen
- Ketorolac
- Labetalol
- Lacosamide
- Lanreotide
- Lansoprazole; Naproxen
- Lapatinib
- Lasmiditan
- Lefamulin
- Lesinurad
- Lesinurad; Allopurinol
- Letermovir
- Levobetaxolol
- Levobunolol
- Levodopa
- Lisdexamfetamine
- Lithium
- Lopinavir; Ritonavir
- Loratadine; Pseudoephedrine
- Lorlatinib
- Lovastatin
- Lovastatin; Niacin
- Lumacaftor; Ivacaftor
- Lurasidone
- Meclofenamate Sodium
- Mefenamic Acid
- Melatonin
- Meloxicam
- Mephobarbital
- Mestranol; Norethindrone
- Methamphetamine
- Methohexital
- Methoxsalen
- Methylphenidate
- Methysergide
- Metoprolol
- Mifepristone
- Milrinone
- Mitotane
- Nabumetone
- Nadolol
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Nebivolol
- Nebivolol; Valsartan
- Nefazodone
- Nelfinavir
- Nesiritide, BNP
- Neuromuscular blockers
- Nevirapine
- Niacin, Niacinamide
- Niacin; Simvastatin
- Nitrates
- Nitroglycerin
- Nitroprusside
- Nonsteroidal antiinflammatory drugs
- Octreotide
- Olanzapine
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Oritavancin
- Osilodrostat
- Oxaprozin
- Oxymetazoline
- Palbociclib
- Paliperidone
- Pasireotide
- Pazopanib
- Penbutolol
- Pentobarbital
- Pentoxifylline
- Phenelzine
- Phenobarbital
- Phenylephrine
- Phenylephrine; Promethazine
- Photosensitizing agents (topical)
- Pindolol
- Piroxicam
- Posaconazole
- Prazosin
- Primidone
- Procainamide
- Procaine
- Propofol
- Propranolol
- Protease inhibitors
- Pseudoephedrine
- Quinidine
- Rasagiline
- Red Yeast Rice
- Remifentanil
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
- Rifampin
- Rifapentine
- Risperidone
- Ritonavir
- Rofecoxib
- Rucaparib
- Saquinavir
- Secobarbital
- Segesterone Acetate; Ethinyl Estradiol
- Selegiline
- Selpercatinib
- Sevoflurane
- Silodosin
- Simeprevir
- Sincalide
- Sotalol
- St. John’s Wort, Hypericum perforatum
- Streptogramins
- Sufentanil
- Sulindac
- Tamsulosin
- Tazemetostat
- Telaprevir
- Telithromycin
- Telotristat Ethyl
- Temsirolimus
- Tetrabenazine
- Tetracaine
- Thalidomide
- Thiopental
- Thiothixene
- Timolol
- Tipranavir
- Tolmetin
- Tranylcypromine
- Trazodone
- Tucatinib
- Valdecoxib
- Vemurafenib
- Verteporfin
- Voriconazole
- Yohimbine
- Zafirlukast
- Ziprasidone
