Isoniazid and Rifampin Brand Name– IsonaRif | Rifamate
What is Isoniazid and Rifampin
The combination product of isoniazid and rifampin is used to treat pulmonary tuberculosis in patients already established on a fixed dosage regimen.
This combination has demonstrated bactericidal activity against both intracellular and extracellular Mycobacterium tuberculosis organisms.
Multiple antitubercular drugs are given together to prevent the development of resistant strains of Mycobacterium tuberculosis.
This product was developed to promote patient adherence and was approved by the FDA in July 1975.
Indications
- Mycobacterium tuberculosis
- tuberculosis infection
Side Effects
- acute generalized exanthematous pustulosis (AGEP)
- agranulocytosis
- anaphylactoid reactions
- anemia
- angioedema
- anorexia
- aplastic anemia
- ataxia
- bleeding
- bone pain
- bronchospasm
- chest pain (unspecified)
- chills
- cholestasis
- confusion
- conjunctivitis
- contact lens discoloration
- cough
- diarrhea
- disseminated intravascular coagulation (DIC)
- dizziness
- drowsiness
- Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
- dyspepsia
- dyspnea
- elevated hepatic enzymes
- encephalopathy
- eosinophilia
- erythema multiforme
- exfoliative dermatitis
- fatigue
- fever
- flatulence
- flushing
- gynecomastia
- headache
- hematuria
- hemolysis
- hemolytic anemia
- hepatic failure
- hepatitis
- hepatotoxicity
- hyperbilirubinemia
- hyperglycemia
- hyperuricemia
- hypotension
- interstitial nephritis
- intracranial bleeding
- jaundice
- leukopenia
- lupus-like symptoms
- lymphadenopathy
- maculopapular rash
- menstrual irregularity
- metabolic acidosis
- myalgia
- nausea
- neutropenia
- optic atrophy
- optic neuritis
- palpitations
- paresthesias
- pemphigus
- peripheral neuropathy
- porphyria
- pruritus
- psychosis
- purpura
- pyrosis (heartburn)
- rash
- renal failure (unspecified)
- seizures
- sideroblastic anemia
- Stevens-Johnson syndrome
- syncope
- thrombocytopenia
- tooth discoloration
- toxic epidermal necrolysis
- urine discoloration
- urticaria
- vasculitis
- visual impairment
- vitamin B6 deficiency
- vitamin D deficiency
- vomiting
- weakness
- wheezing
Monitoring Parameters
- CBC
- INR
- LFTs
- ophthalmologic exam
- prothrombin time (PT)
- serum bilirubin
- serum creatinine
- serum uric acid
Contraindications
- acquired immunodeficiency syndrome (AIDS)
- alcoholism
- anticoagulant therapy
- Black patients
- breast-feeding
- children
- colitis
- contact lenses
- diabetes mellitus
- diarrhea
- females
- geriatric
- GI disease
- gout
- hepatic disease
- hepatitis
- hepatotoxicity
- Hispanic patients
- human immunodeficiency virus (HIV) infection
- hyperuricemia
- infants
- inflammatory bowel disease
- malnutrition
- MAOI therapy
- neonates
- peripheral neuropathy
- pregnancy
- pseudomembranous colitis
- renal failure
- renal impairment
- rifamycin hypersensitivity
- ulcerative colitis
- visual disturbance
- vitamin K deficiency
Interactions
- Abacavir; Dolutegravir; Lamivudine
- Abacavir; Lamivudine, 3TC; Zidovudine, ZDV
- Abemaciclib
- Abiraterone
- Acalabrutinib
- Acetaminophen
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Diphenhydramine
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Pseudoephedrine
- Acetaminophen; Tramadol
- Acetohexamide
- Afatinib
- Aldesleukin, IL-2
- Alendronate; Cholecalciferol
- Alfentanil
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Valsartan
- Alogliptin; Pioglitazone
- Alosetron
- Alpelisib
- Alprazolam
- Altretamine
- Aluminum Hydroxide
- Aluminum Hydroxide; Magnesium Carbonate
- Aluminum Hydroxide; Magnesium Hydroxide
- Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
- Aluminum Hydroxide; Magnesium Trisilicate
- Aminosalicylate sodium, Aminosalicylic acid
- Amiodarone
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amprenavir
- Anagrelide
- Antacids
- Apixaban
- Apremilast
- Aprepitant, Fosaprepitant
- Aripiprazole
- Armodafinil
- Artemether; Lumefantrine
- Artesunate
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atazanavir
- Atazanavir; Cobicistat
- Atomoxetine
- Atorvastatin
- Atorvastatin; Ezetimibe
- Atovaquone
- Atovaquone; Proguanil
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Avanafil
- Avapritinib
- Avatrombopag
- Axitinib
- Azelastine; Fluticasone
- Bacillus Calmette-Guerin Vaccine, BCG
- Bedaquiline
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Bendamustine
- Benzhydrocodone; Acetaminophen
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Bepridil
- Betrixaban
- Bicalutamide
- Bictegravir; Emtricitabine; Tenofovir Alafenamide
- Bisoprolol
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Boceprevir
- Bortezomib
- Bosentan
- Bosutinib
- Brentuximab vedotin
- Brexpiprazole
- Brigatinib
- Brivaracetam
- Bromocriptine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Budesonide
- Budesonide; Formoterol
- Bupivacaine
- Bupivacaine Liposomal
- Bupivacaine; Lidocaine
- Buprenorphine
- Buprenorphine; Naloxone
- Bupropion
- Bupropion; Naltrexone
- Buspirone
- Cabozantinib
- Caffeine
- Caffeine; Ergotamine
- Calcium Carbonate
- Calcium Carbonate; Magnesium Hydroxide
- Calcium Carbonate; Risedronate
- Calcium Carbonate; Simethicone
- Canagliflozin
- Canagliflozin; Metformin
- Cannabidiol
- Capmatinib
- Capreomycin
- Carbamazepine
- Carbidopa
- Carbidopa; Levodopa
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Cariprazine
- Carisoprodol
- Carvedilol
- Caspofungin
- Cefazolin
- Celecoxib
- Ceritinib
- Cevimeline
- Chloramphenicol
- Chlordiazepoxide
- Chlordiazepoxide; Clidinium
- Chloroquine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpropamide
- Cilostazol
- Cinacalcet
- Ciprofloxacin
- Cisapride
- Citalopram
- Clarithromycin
- Clindamycin
- Clobazam
- Clomipramine
- Clonazepam
- Clopidogrel
- Clorazepate
- Clozapine
- Cobicistat
- Cobimetinib
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Colchicine
- Colchicine; Probenecid
- COMT inhibitors
- Conivaptan
- Conjugated Estrogens
- Conjugated Estrogens; Bazedoxifene
- Conjugated Estrogens; Medroxyprogesterone
- Copanlisib
- Crizotinib
- Cyclophosphamide
- Cycloserine
- Cyclosporine
- Dabigatran
- Daclatasvir
- Dapagliflozin
- Dapagliflozin; Metformin
- Dapagliflozin; Saxagliptin
- Dapsone
- Darifenacin
- Darolutamide
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Dasatinib
- Deferasirox
- Deflazacort
- Delavirdine
- Desipramine
- Desvenlafaxine
- Dexamethasone
- Dexlansoprazole
- Dextromethorphan; Quinidine
- Diazepam
- Dichlorphenamide
- Dienogest; Estradiol valerate
- Diethylstilbestrol, DES
- Digoxin
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diltiazem
- Diphenhydramine; Hydrocodone; Phenylephrine
- Disopyramide
- Disulfiram
- Docetaxel
- Dofetilide
- Dolasetron
- Dolutegravir
- Dolutegravir; Lamivudine
- Dolutegravir; Rilpivirine
- Donepezil
- Donepezil; Memantine
- Doravirine
- Doravirine; Lamivudine; Tenofovir disoproxil fumarate
- Doxepin
- Doxercalciferol
- Doxorubicin
- Doxycycline
- Dronabinol
- Dronedarone
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Duloxetine
- Duvelisib
- Edoxaban
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elagolix
- Elagolix; Estradiol; Norethindrone acetate
- Elbasvir; Grazoprevir
- Elexacaftor; tezacaftor; ivacaftor
- Eliglustat
- Eltrombopag
- Eluxadoline
- Elvitegravir
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Enalapril, Enalaprilat
- Enalapril; Felodipine
- Enalapril; Hydrochlorothiazide, HCTZ
- Encorafenib
- Enflurane
- Entacapone
- Entrectinib
- Enzalutamide
- Eravacycline
- Erdafitinib
- Ergocalciferol, Vitamin D2
- Erlotinib
- Erythromycin
- Erythromycin; Sulfisoxazole
- Escitalopram
- Esomeprazole
- Esomeprazole; Naproxen
- Estazolam
- Esterified Estrogens
- Esterified Estrogens; Methyltestosterone
- Estradiol
- Estradiol Cypionate; Medroxyprogesterone
- Estradiol; Levonorgestrel
- Estradiol; Norethindrone
- Estradiol; Norgestimate
- Estradiol; Progesterone
- Estrogens
- Estropipate
- Eszopiclone
- Ethambutol
- Ethanol
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Ethionamide
- Ethotoin
- Etonogestrel
- Etravirine
- Everolimus
- Exemestane
- Ezetimibe; Simvastatin
- Fedratinib
- Felodipine
- Fenfluramine
- Fentanyl
- Fesoterodine
- Fexofenadine
- Fexofenadine; Pseudoephedrine
- Flibanserin
- Fluconazole
- Fluoxetine
- Fluoxetine; Olanzapine
- Flurazepam
- Fluticasone
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Fluvastatin
- Fluvoxamine
- food
- Fosamprenavir
- Fosphenytoin
- Fostamatinib
- Fostemsavir
- Gefitinib
- Gemfibrozil
- Gilteritinib
- Glasdegib
- Glecaprevir; Pibrentasvir
- Glimepiride
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- Glipizide
- Glipizide; Metformin
- Glyburide
- Glyburide; Metformin
- Green Tea
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guanfacine
- Haloperidol
- Halothane
- Homatropine; Hydrocodone
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydroxychloroquine
- Hydroxyprogesterone
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibrutinib
- Ibuprofen; Oxycodone
- Idelalisib
- Ifosfamide
- Iloperidone
- Imatinib
- Imipramine
- Indinavir
- Irinotecan
- Irinotecan Liposomal
- Isavuconazonium
- Isocarboxazid
- Isoflurane
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isradipine
- Istradefylline
- Itraconazole
- Ivabradine
- Ivacaftor
- Ivosidenib
- Ixabepilone
- Ixazomib
- Ketoconazole
- Lamivudine, 3TC; Zidovudine, ZDV
- Lamotrigine
- Lansoprazole
- Lansoprazole; Naproxen
- Lapatinib
- Larotrectinib
- Ledipasvir; Sofosbuvir
- Lefamulin
- Leflunomide
- Lemborexant
- Lesinurad
- Lesinurad; Allopurinol
- Letermovir
- Leuprolide; Norethindrone
- Levobupivacaine
- Levodopa
- Levomethadyl
- Levomilnacipran
- Levonorgestrel
- Levothyroxine
- Levothyroxine; Liothyronine (Porcine)
- Levothyroxine; Liothyronine (Synthetic)
- Lidocaine
- Lidocaine; Prilocaine
- Linagliptin
- Linagliptin; Metformin
- Linezolid
- Liothyronine
- Lomitapide
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Lorlatinib
- Losartan
- Lovastatin
- Lovastatin; Niacin
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Lumateperone
- Lurasidone
- Lurbinectedin
- Macimorelin
- Macitentan
- Magnesium Hydroxide
- Maraviroc
- Mebendazole
- Medroxyprogesterone
- Mefloquine
- Megestrol
- Melatonin
- Meperidine
- Meperidine; Promethazine
- Mestranol; Norethindrone
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Methadone
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methylene Blue
- Methylprednisolone
- Metoprolol
- Mexiletine
- Midazolam
- Midostaurin
- Mifepristone
- Milnacipran
- Mirtazapine
- Modafinil
- Montelukast
- Morphine
- Morphine; Naltrexone
- Moxifloxacin
- Mycophenolate
- Naldemedine
- Naloxegol
- Nanoparticle Albumin-Bound Paclitaxel
- Nateglinide
- Nebivolol
- Nebivolol; Valsartan
- Nelfinavir
- Neratinib
- Netupitant, Fosnetupitant; Palonosetron
- Nevirapine
- Niacin; Simvastatin
- Nicardipine
- Nifedipine
- Nilotinib
- Nimodipine
- Nintedanib
- Nisoldipine
- Norethindrone
- Norfloxacin
- Nortriptyline
- Olanzapine
- Olaparib
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole
- Omeprazole; Amoxicillin; Rifabutin
- Omeprazole; Sodium Bicarbonate
- Ondansetron
- Osilodrostat
- Osimertinib
- Ospemifene
- Oxcarbazepine
- Oxybutynin
- Oxycodone
- Ozanimod
- Paclitaxel
- Palbociclib
- Paliperidone
- Paricalcitol
- Paroxetine
- Pazopanib
- Pemigatinib
- Pentobarbital
- Perampanel
- Perindopril; Amlodipine
- Perphenazine; Amitriptyline
- Pexidartinib
- Phenelzine
- Phenobarbital
- Phenothiazines
- Phenytoin
- Pimavanserin
- Pioglitazone
- Pitavastatin
- Pitolisant
- Polatuzumab Vedotin
- Pomalidomide
- Ponatinib
- Posaconazole
- Pravastatin
- Praziquantel
- Prednisolone
- Prednisone
- Primidone
- Probenecid
- Procarbazine
- Progesterone
- Propafenone
- Propranolol
- Protriptyline
- Pyrazinamide, PZA
- Quazepam
- Quetiapine
- Quinidine
- Quinine
- Raltegravir
- Ramelteon
- Ranolazine
- Rasagiline
- Red Yeast Rice
- Regorafenib
- Remdesivir
- Repaglinide
- Revefenacin
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
- Rifampin
- Rifapentine
- Rilpivirine
- Riluzole
- Rimegepant
- Riociguat
- Ripretinib
- Risperidone
- Ritonavir
- Rivaroxaban
- Rofecoxib
- Roflumilast
- Rolapitant
- Romidepsin
- Ropinirole
- Rosiglitazone
- Ruxolitinib
- Sacubitril; Valsartan
- Safinamide
- Sapropterin
- Saquinavir
- Saxagliptin
- Segesterone Acetate; Ethinyl Estradiol
- Selegiline
- Selexipag
- Selpercatinib
- Selumetinib
- Sertraline
- Sevoflurane
- Sibutramine
- Sildenafil
- Simeprevir
- Simvastatin
- Simvastatin; Sitagliptin
- Siponimod
- Sirolimus
- Sodium Bicarbonate
- Sofosbuvir
- Sofosbuvir; Velpatasvir
- Sofosbuvir; Velpatasvir; Voxilaprevir
- Sonidegib
- Sorafenib
- Sufentanil
- Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
- Sulfasalazine
- Sulfonylureas
- Sunitinib
- Suvorexant
- Tacrolimus
- Tadalafil
- Tamoxifen
- Tasimelteon
- Tazemetostat
- Tedizolid
- Telaprevir
- Telithromycin
- Telotristat Ethyl
- Temsirolimus
- Teniposide
- Tenofovir Alafenamide
- Terbinafine
- Teriflunomide
- Tezacaftor; Ivacaftor
- Theophylline, Aminophylline
- Thiotepa
- Thiothixene
- Thyroid hormones
- Ticagrelor
- Tinidazole
- Tipranavir
- Tocainide
- Tofacitinib
- Tolazamide
- Tolbutamide
- Tolvaptan
- Toremifene
- Torsemide
- Trabectedin
- Tramadol
- Trandolapril; Verapamil
- Tranylcypromine
- Trazodone
- Treprostinil
- Tretinoin, ATRA
- Triamcinolone
- Triazolam
- Tricyclic antidepressants
- Trimethoprim
- Trimetrexate
- Trimipramine
- Tucatinib
- Ubrogepant
- Ulipristal
- Upadacitinib
- Valbenazine
- Valproic Acid, Divalproex Sodium
- Valsartan
- Vandetanib
- Vemurafenib
- Venetoclax
- Venlafaxine
- Verapamil
- Vilazodone
- Vincristine
- Vincristine Liposomal
- Vinorelbine
- Vorapaxar
- Voriconazole
- Vortioxetine
- Voxelotor
- Warfarin
- Zalcitabine, ddC
- Zaleplon
- Zanubrutinib
- Zidovudine, ZDV
- Ziprasidone
- Zolpidem
- Zonisamide
