Iron Sucrose Sucroferric Oxyhydroxide Brand Name– Velphoro | Venofer
What is Iron Sucrose Sucroferric Oxyhydroxide
Intravenous iron sucrose is approved for the treatment of iron deficiency anemia in patients with chronic kidney disease.
Oral sucroferric oxyhydroxide, which is a synonym for iron sucrose and is the same therapeutic ingredient per the National Library of Medicine, is approved as a phosphate binder for the control of serum phosphorus levels in patients with chronic kidney disease on dialysis.
Intravenous iron sucrose is one of the oldest parenteral iron preparations available; it has been used clinically for more than 50 years.
Intravenous iron is preferred over oral iron therapy when rapid repletion of iron-depleted patients is desired. Intravenous iron has been used to treat the anemia associated with dialysis and may reduce the need for erythropoietin dosage by about 40%.
Intravenous iron sucrose appears less likely to cause hypersensitivity reactions than iron dextran and has been used in patients with a hypersensitivity to iron dextran.
However, hypersensitivity may also occur with intravenous iron sucrose; serious and fatal anaphylactic reactions have been reported. Intravenous iron sucrose rapidly increases serum iron concentrations, which can be reliably measured 48 hours after administration.
Oral sucroferric oxyhydroxide is a calcium-free phosphate binder. In clinical trials, oral sucroferric oxyhydroxide effectively lowered serum phosphorus concentrations at doses of 1,000 to 3,000 mg/day PO with treatment effect seen as early as 1 to 2 weeks.
This effect was consistently maintained through 12 months of treatment in a 28-week extension study
Indications
- anemia
- hyperphosphatemia
- iron-deficiency anemia
For the treatment of iron-deficiency anemia in patients with chronic kidney disease
Side Effects
- abdominal pain
- anaphylactic shock
- anaphylactoid reactions
- angioedema
- arthralgia
- asthenia
- back pain
- bradycardia
- bronchospasm
- chest pain (unspecified)
- confusion
- conjunctivitis
- constipation
- cough
- diarrhea
- dizziness
- dysgeusia
- dyspnea
- edema
- fever
- gout
- headache
- heart failure
- hemosiderosis
- hyperglycemia
- hyperhidrosis
- hypertension
- hypervolemia
- hypoglycemia
- hypotension
- infection
- injection site reaction
- muscle cramps
- musculoskeletal pain
- myalgia
- nasal congestion
- nausea
- paresthesias
- peripheral edema
- pharyngitis
- pruritus
- rash
- seizures
- sinusitis
- stool discoloration
- tooth discoloration
- vomiting
Monitoring Parameters
- ferritin
- hemoglobin/hematocrit
- serum iron
- serum phosphate
- transferrin
Contraindications
- breast-feeding
- cardiac disease
- children
- hemochromatosis
- hemoglobinopathy
- hemosiderosis
- hepatic disease
- hypotension
- infants
- intramuscular administration
- neonates
- peritonitis
- pregnancy
- requires a specialized care setting
- subcutaneous administration
Interactions
- Acetaminophen; Aspirin, ASA; Caffeine
- Alendronate
- Alendronate; Cholecalciferol
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Baloxavir Marboxil
- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Cephalexin
- Darbepoetin Alfa
- Deferasirox
- Deferiprone
- Deferoxamine
- Demeclocycline
- Dimercaprol
- Doxycycline
- enteral feedings
- Epoetin Alfa
- Erdafitinib
- food
- Iron
- Levothyroxine
- Levothyroxine; Liothyronine (Porcine)
- Levothyroxine; Liothyronine (Synthetic)
- Liothyronine
- Methoxy polyethylene glycol-epoetin beta
- Minocycline
- Omadacycline
- Paricalcitol
- Sarecycline
- Tetracycline
- Tetracyclines
- Thyroid hormones
- Trientine
