Iohexol Brand Name– Omnipaque
What is Iohexol
Iohexol is an iodinated nonionic, low-osmolar contrast medium used for visualization during angiography and excretory urography.
Iohexol is used to enhance computed tomography head and body imaging and to investigate the presence of cerebral infarctions, active infections, arteriovenous malformations, aneurysms and lesions or tumors (both malignant and nonneoplastic) in the liver, kidneys, pancreas, aorta, abdominal cavity, pelvis, retroperitoneal space, and the mediastinum.
Iohexol can be used orally for radiographic examinations of the gastrointestinal tract and is particularly useful for this indication when barium is contraindicated.
Iohexol can be administered into joints for arthrography and into body cavities for visualization of the uterus, fallopian tubes, peritoneum, and bladder.
In addition, iohexol can be administered intrathecally for use during myelography and to enhance myelographic computed tomography imaging.
Iohexol was approved by the FDA on December 26, 1985.
Indications
- angiography
- arthrography
- computed tomography (CT) imaging
- digital subtraction angiography (DSA)
- endoscopic retrograde cholangiopancreatography (ERCP)
- gastrointestinal radiography
- herniography
- hysterosalpingography
- myelography
- urography
- voiding cystourethrography (VCU)
Side Effects
- abdominal pain
- acute generalized exanthematous pustulosis (AGEP)
- agitation
- amblyopia
- amnesia
- anaphylactoid reactions
- angina
- angioedema
- anorexia
- anuria
- anxiety
- aphasia
- apnea
- arachnoiditis
- aseptic meningitis
- asterixis
- asystole
- ataxia
- back pain
- bleeding
- bradycardia
- bronchospasm
- cardiac arrest
- chest pain (unspecified)
- chills
- coma
- confusion
- conjunctivitis
- cough
- cyanosis
- depression
- diaphoresis
- diarrhea
- diplopia
- disseminated intravascular coagulation (DIC)
- dizziness
- drowsiness
- Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
- dysgeusia
- dyspepsia
- dyspnea
- ecchymosis
- erythema
- fatigue
- fever
- flushing
- Guillain-Barre syndrome
- hallucinations
- headache
- hematoma
- hematuria
- hostility
- hot flashes
- hyperesthesia
- hyperhidrosis
- hyperreflexia
- hypertension
- hypertensive crisis
- hyperthermia
- hyperthyroidism
- hypertonia
- hypotension
- hypothyroidism
- hypovolemia
- hypoxia
- injection site reaction
- insomnia
- involuntary movements
- irritability
- lacrimation
- laryngeal edema
- maculopapular rash
- malaise
- meningitis
- muscle cramps
- myelitis
- myocardial infarction
- myoclonia
- nasal congestion
- nausea
- neuropathic pain
- neutropenia
- nystagmus
- oliguria
- pallor
- paresis
- paresthesias
- peripheral edema
- peripheral neuropathy
- peripheral vasodilation
- petechiae
- photophobia
- polyuria
- proteinuria
- pruritus
- psychosis
- pulmonary edema
- purpura
- rash
- renal failure (unspecified)
- renal tubular necrosis
- restlessness
- retroperitoneal bleeding
- rhabdomyolysis
- rhinitis
- seizures
- sinus tachycardia
- skin necrosis
- sneezing
- Stevens-Johnson syndrome
- stroke
- syncope
- thromboembolism
- thrombosis
- thyrotoxicosis
- tinnitus
- tissue necrosis
- toxic epidermal necrolysis
- tremor
- urinary retention
- urticaria
- ventricular fibrillation
- vertigo
- visual impairment
- vomiting
- weakness
- wheezing
- xerostomia
Monitoring Parameters
- serum creatinine/BUN
Contraindications
- alcoholism
- anuria
- arteriosclerosis
- asthma
- atopy
- breast-feeding
- cardiac disease
- cervical cancer
- children
- coagulopathy
- corticosteroid therapy
- dehydration
- diabetes mellitus
- emphysema
- extravasation
- females
- geriatric
- heart failure
- hepatic disease
- hypertension
- hyperthyroidism
- hypothyroidism
- increased intracranial pressure
- infants
- infection
- intracranial mass
- intrathecal administration
- iodine hypersensitivity
- menstruation
- multiple myeloma
- multiple sclerosis
- myasthenia gravis
- neonates
- parenteral administration
- pheochromocytoma
- pregnancy
- premature neonates
- pulmonary disease
- pulmonary hypertension
- QT prolongation
- radiopaque contrast media hypersensitivity
- renal disease
- renal failure
- renal impairment
- seizures
- sepsis
- serious rash
- sickle cell disease
- thromboembolic disease
- thyroid disease
- thyrotoxicosis
- urinary tract infection (UTI)
- uterine cancer
- valvular heart disease
Interactions
- Acebutolol
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Tramadol
- Acyclovir
- Aldesleukin, IL-2
- Alogliptin; Metformin
- Aminoglycosides
- Amiodarone
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amoxapine
- Amphetamine
- Amphetamine; Dextroamphetamine
- Amphetamine; Dextroamphetamine Salts
- Amphotericin B
- Angiotensin-converting enzyme inhibitors
- Aprotinin
- Aripiprazole
- Asenapine
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Atenolol
- Atenolol; Chlorthalidone
- Bendroflumethiazide; Nadolol
- Benzphetamine
- Beta-blockers
- Betamethasone
- Betaxolol
- Bictegravir; Emtricitabine; Tenofovir Alafenamide
- Bisoprolol
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Brexpiprazole
- Brimonidine; Timolol
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Dextromethorphan; Phenylephrine
- Bumetanide
- Bupropion
- Bupropion; Naltrexone
- Caffeine
- Caffeine; Ergotamine
- Canagliflozin; Metformin
- Capreomycin
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Phenylephrine
- Carteolol
- Carvedilol
- Chlophedianol; Guaifenesin; Phenylephrine
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Phenylephrine
- Cisplatin
- Clomipramine
- Clonazepam
- Clozapine
- Cocaine
- Codeine; Phenylephrine; Promethazine
- Colistimethate, Colistin, Polymyxin E
- Cortisone
- Cyclobenzaprine
- Cyclosporine
- Dapagliflozin; Metformin
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Deferasirox
- Desipramine
- Dexamethasone
- Dexmethylphenidate
- Dextroamphetamine
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin; Phenylephrine
- Diethylpropion
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Phenylephrine
- Dopamine
- Doravirine; Lamivudine; Tenofovir disoproxil fumarate
- Dorzolamide; Timolol
- Doxepin
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Emtricitabine; Tenofovir alafenamide
- Emtricitabine; Tenofovir disoproxil fumarate
- Entecavir
- Ephedrine
- Ertugliflozin; Metformin
- Esmolol
- Ethacrynic Acid
- Ethanol
- Fluoxetine; Olanzapine
- Furosemide
- Glipizide; Metformin
- Glyburide; Metformin
- Green Tea
- Guaifenesin; Phenylephrine
- Haloperidol
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrocodone; Phenylephrine
- Hydrocortisone
- Ibandronate
- Iloperidone
- Imipramine
- Labetalol
- Lamivudine; Tenofovir Disoproxil Fumarate
- Levobetaxolol
- Levobunolol
- Linagliptin; Metformin
- Lisdexamfetamine
- Loop diuretics
- Lorazepam
- Loxapine
- Lurasidone
- Maprotiline
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methamphetamine
- Methylphenidate
- Methylprednisolone
- Metoprolol
- Midodrine
- Molindone
- Monoamine oxidase inhibitors
- Nadolol
- Nebivolol
- Nebivolol; Valsartan
- Nonsteroidal antiinflammatory drugs
- Norepinephrine
- Nortriptyline
- Olanzapine
- Oxaliplatin
- Pamidronate
- Pemoline
- Penbutolol
- Perphenazine; Amitriptyline
- Phendimetrazine
- Phenothiazines
- Phentermine
- Phentermine; Topiramate
- Phenylephrine
- Phenylephrine; Promethazine
- Pimozide
- Pindolol
- Polymyxins
- Prednisolone
- Propranolol
- Protriptyline
- Quetiapine
- Risperidone
- Sodium Iodide
- Sodium Oxybate
- Sotalol
- Telbivudine
- Tenofovir Alafenamide
- Tenofovir Alafenamide
- Tenofovir, PMPA
- Thiothixene
- Thyroid hormones
- Timolol
- Torsemide
- Tramadol
- Triamcinolone
- Tricyclic antidepressants
- Trimipramine
- Valacyclovir
- Ziprasidone
- Zoledronic Acid
