Insoluble Prussian Blue Brand Name– Radiogardase
What is Insoluble Prussian Blue
Insoluble Prussian Blue (ferric hexacyanoferrate, Radiogardase™) is an oral radioactive decontamination agent used in the case of cesium or thallium exposure.
The drug increases the rate of cesium and thallium elimination from the body by binding the isotopes in the gastrointestinal tract. Treatment for possible cesium or thallium exposure should begin as soon as possible, with contamination verified as soon as possible.
If treatment cannot be started right away, patients should be given Insoluble Prussian Blue as soon as it becomes available, as treatment is still effective even after time has elapsed since exposure.
When the sources of radiation contamination are multiple or unknown, other therapies (such as potassium iodide, calcium or zinc DTPA, or sodium alginate) can be used together with Insoluble Prussian Blue.
The U.S. national stockpile of products for emergency use includes stores of Insoluble Prussian Blue.
Those who are concerned about the possibility of being contaminated with radioactive cesium or thallium should be encouraged to discuss such issues with their health care provider for advice and treatment.
The FDA approved the Radiogardase™ brand of Insoluble Prussian Blue in October 2003.
Indications
- radiation exposure
For the treatment of radiation exposure in patients with known or suspected internal contamination with radioactive cesium and/or radioactive or non-radioactive thallium to increase the rate of elimination
Side Effects
- constipation
- dyspepsia
- hypokalemia
- stool discoloration
- tooth discoloration
Monitoring Parameters
- CBC with differential
- serum electrolytes
Contraindications
- bone marrow suppression
- breast-feeding
- burns
- cardiac arrhythmias
- children
- constipation
- electrolyte imbalance
- GI obstruction
- hepatic disease
- hypokalemia
- ileus
- infants
- neonates
- neutropenia
- pregnancy
- thrombocytopenia
- trauma
Interactions
- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Demeclocycline
- Doxycycline
- Minocycline
- Omadacycline
- Sarecycline
- Tetracycline
- Tetracyclines
