Indinavir Brand Name– Chemet | Crixivan
What is Indinavir
Indinavir is a protease inhibitor approved for use in combination with other antiretroviral medications to treat human immunodeficiency virus (HIV-1) infections.
Concerns about high pill burden (when used without ritonavir) and the potential for nephrolithiasis may limit its use.
Adequate hydration (1.5 liters per 24 hour period) is recommended in all patients treated with indinavir.
Indications
- human immunodeficiency virus (HIV)
- human immunodeficiency virus (HIV) infection
Side Effects
- abdominal pain
- alopecia
- anaphylactoid reactions
- anemia
- angina
- anorexia
- appetite stimulation
- arthralgia
- asthenia
- back pain
- bleeding
- cough
- crystalluria
- Cushingoid features
- depression
- diabetes mellitus
- diabetic ketoacidosis
- diarrhea
- dizziness
- drowsiness
- dysgeusia
- dyspepsia
- dysuria
- elevated hepatic enzymes
- erythema multiforme
- fatigue
- fever
- flank pain
- gastroesophageal reflux
- GI bleeding
- gynecomastia
- headache
- hematoma
- hematuria
- hemolytic anemia
- hepatic failure
- hepatitis
- hyperamylasemia
- hyperbilirubinemia
- hypercholesterolemia
- hyperglycemia
- hyperlipidemia
- hypertriglyceridemia
- interstitial nephritis
- intracranial bleeding
- jaundice
- lipodystrophy
- malaise
- myocardial infarction
- nausea
- nephrolithiasis
- neutropenia
- pancreatitis
- paresthesias
- pruritus
- rash
- renal tubular obstruction
- skin hyperpigmentation
- Stevens-Johnson syndrome
- thrombocytopenia
- urticaria
- vasculitis
- vomiting
- xerosis
Monitoring Parameters
- blood glucose
- CBC with differential
- CD4+ T cell count
- hepatitis B serology
- LFTs
- plasma hepatitis C RNA
- plasma HIV RNA
- pregnancy testing
- serum bilirubin (total and direct)
- serum cholesterol
- serum lipid profile
- urinalysis
Contraindications
- autoimmune disease
- breast-feeding
- children
- dehydration
- diabetes mellitus
- diabetic ketoacidosis
- Graves’ disease
- Guillain-Barre syndrome
- hemophilia
- hepatic disease
- hepatitis
- hepatitis B and HIV coinfection
- hepatitis C and HIV coinfection
- human immunodeficiency virus (HIV) infection resistance
- hypercholesterolemia
- hyperglycemia
- hyperlipidemia
- hypertriglyceridemia
- immune reconstitution syndrome
- infants
- labor
- neonates
- nephrolithiasis
- pancreatitis
- pregnancy
- tuberculosis
Interactions
- Abacavir; Lamivudine, 3TC; Zidovudine, ZDV
- Abemaciclib
- Acalabrutinib
- Acarbose
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Codeine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Propoxyphene
- Adefovir
- Ado-Trastuzumab emtansine
- Aldesleukin, IL-2
- Alfentanil
- Alfuzosin
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Almotriptan
- Alogliptin
- Alogliptin; Metformin
- Alogliptin; Pioglitazone
- Alosetron
- Alpha-glucosidase Inhibitors
- Alprazolam
- Amiodarone
- Amitriptyline; Chlordiazepoxide
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amobarbital
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Apalutamide
- Aprepitant, Fosaprepitant
- Aripiprazole
- Artemether; Lumefantrine
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Atazanavir
- Atazanavir; Cobicistat
- Atorvastatin
- Atorvastatin; Ezetimibe
- Atovaquone
- Atovaquone; Proguanil
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Avanafil
- Avapritinib
- Axitinib
- Azelastine; Fluticasone
- Barbiturates
- Bedaquiline
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Benzhydrocodone; Acetaminophen
- Bepridil
- Betamethasone
- Bicalutamide
- Boceprevir
- Bortezomib
- Bosentan
- Bosutinib
- Brentuximab vedotin
- Brexpiprazole
- Brigatinib
- Bromocriptine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Budesonide
- Budesonide; Formoterol
- Bupivacaine
- Bupivacaine Liposomal
- Bupivacaine; Lidocaine
- Buprenorphine
- Buprenorphine; Naloxone
- Buspirone
- Butabarbital
- Cabazitaxel
- Cabozantinib
- Caffeine; Ergotamine
- Canagliflozin
- Canagliflozin; Metformin
- Cannabidiol
- Capmatinib
- Carbamazepine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Cariprazine
- Carvedilol
- Cenobamate
- Ceritinib
- Cevimeline
- Chlordiazepoxide
- Chlordiazepoxide; Clidinium
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Cidofovir
- Cilostazol
- Ciprofloxacin
- Cisapride
- Citalopram
- Clarithromycin
- Clindamycin
- Clonazepam
- Clorazepate
- Clozapine
- Cobicistat
- Cobimetinib
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Colchicine
- Colchicine; Probenecid
- Conivaptan
- Conjugated Estrogens
- Conjugated Estrogens; Bazedoxifene
- Conjugated Estrogens; Medroxyprogesterone
- Copanlisib
- Crizotinib
- Cyclosporine
- Dabrafenib
- Daclatasvir
- Dapagliflozin
- Dapagliflozin; Metformin
- Dapagliflozin; Saxagliptin
- Darifenacin
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Dasatinib
- Deflazacort
- Delavirdine
- Dexamethasone
- Dextromethorphan; Quinidine
- Diazepam
- Didanosine, ddI
- Dienogest; Estradiol valerate
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Dihydroergotamine
- Diltiazem
- Diphenhydramine; Hydrocodone; Phenylephrine
- Disopyramide
- Docetaxel
- Dofetilide
- Dolutegravir; Rilpivirine
- Donepezil
- Donepezil; Memantine
- Doravirine
- Doravirine; Lamivudine; Tenofovir disoproxil fumarate
- Doxazosin
- Doxercalciferol
- Doxorubicin
- Dronabinol
- Dronedarone
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Dutasteride
- Dutasteride; Tamsulosin
- Duvelisib
- Echinacea
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elagolix
- Elagolix; Estradiol; Norethindrone acetate
- Elbasvir; Grazoprevir
- Eletriptan
- Elexacaftor; tezacaftor; ivacaftor
- Eliglustat
- Elvitegravir
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Empagliflozin
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Enalapril; Felodipine
- Encorafenib
- Enfortumab vedotin
- Entrectinib
- Enzalutamide
- Eplerenone
- Erdafitinib
- Ergoloid Mesylates
- Ergonovine
- Ergot alkaloids
- Ergotamine
- Erlotinib
- Ertugliflozin; Metformin
- Estazolam
- Esterified Estrogens
- Esterified Estrogens; Methyltestosterone
- Estradiol
- Estradiol Cypionate; Medroxyprogesterone
- Estradiol; Levonorgestrel
- Estradiol; Norethindrone
- Estradiol; Norgestimate
- Estradiol; Progesterone
- Estropipate
- Eszopiclone
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Ethosuximide
- Ethotoin
- Etonogestrel
- Etravirine
- Everolimus
- Ezetimibe; Simvastatin
- Fedratinib
- Felodipine
- Fentanyl
- Fesoterodine
- Flibanserin
- Fluconazole
- Flurazepam
- Fluticasone
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Fluvastatin
- food
- Formoterol; Mometasone
- Fosphenytoin
- Fostamatinib
- Gefitinib
- Gilteritinib
- Glasdegib
- Glecaprevir; Pibrentasvir
- Glipizide; Metformin
- Glyburide; Metformin
- grapefruit juice
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guanfacine
- Halofantrine
- Haloperidol
- Homatropine; Hydrocodone
- Hydantoins
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Ibrutinib
- Ibuprofen; Oxycodone
- Idelalisib
- Ifosfamide
- Iloperidone
- Imatinib
- Incretin Mimetics
- Insulins
- Interferon Alfa-2b; Ribavirin
- Interferons
- Irinotecan
- Irinotecan Liposomal
- Isavuconazonium
- Isoniazid, INH
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Isradipine
- Istradefylline
- Itraconazole
- Ivabradine
- Ivacaftor
- Ivosidenib
- Ixabepilone
- Ketoconazole
- Lacosamide
- Lamivudine, 3TC; Zidovudine, ZDV
- Lanthanum Carbonate
- Lapatinib
- Larotrectinib
- Lefamulin
- Lemborexant
- Lesinurad
- Lesinurad; Allopurinol
- Letermovir
- Leuprolide; Norethindrone
- Levobupivacaine
- Levomethadyl
- Levomilnacipran
- Levonorgestrel
- Levothyroxine
- Levothyroxine; Liothyronine (Porcine)
- Levothyroxine; Liothyronine (Synthetic)
- Lidocaine
- Lidocaine; Prilocaine
- Linagliptin
- Linagliptin; Metformin
- Liothyronine
- Lofexidine
- Lomitapide
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Lorlatinib
- Lovastatin
- Lovastatin; Niacin
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Lumateperone
- Lurasidone
- Lurbinectedin
- Macitentan
- Maraviroc
- Medroxyprogesterone
- Mefloquine
- Megestrol
- Mephobarbital
- Mestranol; Norethindrone
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methadone
- Methohexital
- Methylergonovine
- Methysergide
- Midazolam
- Midostaurin
- Mifepristone
- Miglitol
- Mirtazapine
- Mitotane
- Mometasone
- Naldemedine
- Naloxegol
- Nanoparticle Albumin-Bound Paclitaxel
- Nateglinide
- Nebivolol
- Nebivolol; Valsartan
- Nefazodone
- Nelfinavir
- Neratinib
- Netupitant, Fosnetupitant; Palonosetron
- Nevirapine
- Niacin; Simvastatin
- Nicardipine
- Nifedipine
- Nilotinib
- Nimodipine
- Nisoldipine
- Norethindrone
- Norgestrel
- Olaparib
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole
- Omeprazole; Amoxicillin; Rifabutin
- Omeprazole; Sodium Bicarbonate
- Oritavancin
- Orlistat
- Osilodrostat
- Osimertinib
- Ospemifene
- Oxybutynin
- Oxycodone
- Paclitaxel
- Palbociclib
- Panobinostat
- Paricalcitol
- Pazopanib
- Pemigatinib
- Pentobarbital
- Perampanel
- Pergolide
- Perindopril; Amlodipine
- Pexidartinib
- Phenobarbital
- Phenytoin
- Pimavanserin
- Pimozide
- Polatuzumab Vedotin
- Ponatinib
- Posaconazole
- Pramlintide
- Primidone
- Progesterone
- Propafenone
- Propoxyphene
- Quazepam
- Quetiapine
- Quinidine
- Quinine
- Ramelteon
- Ranolazine
- Red Yeast Rice
- Regorafenib
- Repaglinide
- Retapamulin
- Ribavirin
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
- Rifampin
- Rifapentine
- Rilpivirine
- Rimegepant
- Riociguat
- Ripretinib
- Ritonavir
- Rivaroxaban
- Roflumilast
- Romidepsin
- Rucaparib
- Ruxolitinib
- Sacituzumab Govitecan
- Sapropterin
- Saquinavir
- Saxagliptin
- Secobarbital
- Segesterone Acetate; Ethinyl Estradiol
- Selpercatinib
- Selumetinib
- Sibutramine
- Sildenafil
- Silodosin
- Simeprevir
- Simvastatin
- Simvastatin; Sitagliptin
- Siponimod
- Sirolimus
- Sitagliptin
- Sofosbuvir; Velpatasvir
- Sofosbuvir; Velpatasvir; Voxilaprevir
- Solifenacin
- Somatropin, rh-GH
- Sonidegib
- Sorafenib
- St. John’s Wort, Hypericum perforatum
- Sufentanil
- Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
- Sulfonylureas
- Sunitinib
- Suvorexant
- Tacrolimus
- Tadalafil
- Tamsulosin
- Tasimelteon
- Tazemetostat
- Telaprevir
- Telithromycin
- Telotristat Ethyl
- Temsirolimus
- Terbinafine
- Terfenadine
- Tezacaftor; Ivacaftor
- Thiazolidinediones
- Thiopental
- Thiotepa
- Thyroid hormones
- Ticagrelor
- Tofacitinib
- Tolterodine
- Tolvaptan
- Toremifene
- Trabectedin
- Trandolapril; Verapamil
- Trazodone
- Triamcinolone
- Triazolam
- Trimethoprim
- Trimetrexate
- Tucatinib
- Ubrogepant
- Ulipristal
- Upadacitinib
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- Venetoclax
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- Vinorelbine
- Vorapaxar
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- Zidovudine, ZDV
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