Indapamide

Indapamide Brand Name– Lozol

What is Indapamide

Indapamide is an oral antihypertensive and diuretic.

Although it is a sulfonamide-type diuretic similar to thiazides, indapamide was the first in the class of antihypertensive/diuretics called the indolines.

Although some experts believe attaining goal blood pressure is most important in patients with diabetes mellitus, a recent large, randomized, placebo-controlled trial (ADVANCE, n=11,140) has reported that the administration of a fixed combination of perindopril and indapamide to a broad range of patients with type 2 diabetes mellitus is associated with reduced risks of major vascular events, including death.

After a mean follow-up of 4.3 years, 15.5% of patients in the active treatment group vs. 16.8% in the placebo group had a major macrovascular or microvascular event (relative risk reduction, 9%; 95% CI, 0.83—1.0; p=0.041). Cardiovascular death was significantly lower in the active treatment group vs. placebo group (3.8% vs. 4.6%; 95% CI, 0.68—0.98; p=0.03).

Death from any cause also was significantly lower in the active treatment group vs. placebo group (7.3% vs. 8.5%; 95% CI 0.75—0.98; p=0.03).

Indapamide was approved by the FDA in 1983.

Indications

• edema
• heart failure
• hypertension

For treatment of edema of congestive heart failure

Side Effects

1. abdominal pain
2. agitation
3. agranulocytosis
4. anaphylactoid reactions
5. anxiety
6. aplastic anemia
7. asthenia
8. azotemia
9. back pain
10. bullous rash
11. chest pain (unspecified)
12. constipation
13. cough
14. depression
15. diarrhea
16. dizziness
17. drowsiness
18. dyspepsia
19. elevated hepatic enzymes
20. fatigue
21. fever
22. flushing
23. gastritis
24. glycosuria
25. headache
26. hepatitis
27. hypercalcemia
28. hypercholesterolemia
29. hyperglycemia
30. hypertonia
31. hypertriglyceridemia
32. hyperuricemia
33. hypochloremia
34. hypokalemia
35. hyponatremia
36. hypophosphatemia
37. hypovolemia
38. impotence (erectile dysfunction)
39. increased urinary frequency
40. infection
41. insomnia
42. interstitial nephritis
43. irritability
44. jaundice
45. leukopenia
46. libido decrease
47. maculopapular rash
48. malaise
49. muscle cramps
50. nausea
51. nocturia
52. orthostatic hypotension
53. palpitations
54. pancreatitis
55. paresthesias
56. pharyngitis
57. photosensitivity
58. polyuria
59. premature ventricular contractions (PVCs)
60. pruritus
61. purpura
62. rhinitis
63. rhinorrhea
64. sinusitis
65. Stevens-Johnson syndrome
66. thrombocytopenia
67. toxic epidermal necrolysis
68. urticaria
69. vasculitis
70. vertigo
71. vomiting
72. weakness
73. weight loss
74. xerostomia

Monitoring Parameters

• blood glucose
• serum creatinine/BUN
• serum electrolytes
• serum magnesium
• serum uric acid

Contraindications

• anuria
• breast-feeding
• children
• diabetes mellitus
• electrolyte imbalance
• geriatric
• gout
• hepatic disease
• hypercalcemia
• hyperglycemia
• hyperuricemia
• hypochloremia
• hypokalemia
• hypomagnesemia
• hyponatremia
• hypotension
• hypovolemia
• metabolic alkalosis
• orthostatic hypotension
• parathyroid disease
• pregnancy
• renal disease
• renal failure
• renal impairment
• sulfonamide hypersensitivity
• sunlight (UV) exposure
• sympathectomy
• syncope
• thyroid disease

Interactions

• Acarbose
• Acetaminophen; Aspirin, ASA; Caffeine
• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
• Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
• Acetaminophen; Codeine
• Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
• Acetaminophen; Dextromethorphan; Phenylephrine
• Acetaminophen; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Guaifenesin; Phenylephrine
• Acetaminophen; Hydrocodone
• Acetaminophen; Oxycodone
• Acetaminophen; Pentazocine
• Acetaminophen; Pseudoephedrine
• Acetaminophen; Tramadol
• Acrivastine; Pseudoephedrine
• Alfentanil
• Alfuzosin
• Aliskiren
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• Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
• Aliskiren; Hydrochlorothiazide, HCTZ
• Aliskiren; Valsartan
• Alogliptin; Metformin
• Alpha-glucosidase Inhibitors
• Amiloride
• Amiloride; Hydrochlorothiazide, HCTZ
• Aminolevulinic Acid
• Aminosalicylate sodium, Aminosalicylic acid
• Amiodarone
• Amlodipine; Benazepril
• Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
• Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
• Amlodipine; Olmesartan
• Amlodipine; Telmisartan
• Amlodipine; Valsartan
• Amphetamine; Dextroamphetamine Salts
• Amphotericin B
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• Aspirin, ASA; Carisoprodol; Codeine
• Aspirin, ASA; Citric Acid; Sodium Bicarbonate
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• Brompheniramine; Pseudoephedrine
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• Cabergoline
• Calcium Phosphate, Supersaturated
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• Chlorpheniramine; Hydrocodone
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• Hydrocodone
• Hydrocodone; Ibuprofen
• Hydrocodone; Phenylephrine
• Hydrocodone; Potassium Guaiacolsulfonate
• Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
• Hydrocodone; Pseudoephedrine
• Hydrocortisone
• Hydromorphone
• Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
• Ibuprofen; Oxycodone
• Ibuprofen; Pseudoephedrine
• Iloperidone
• Iloprost
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• Inotersen
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• Phendimetrazine
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• Phentermine
• Phentermine; Topiramate
• Phenylephrine
• Phenylephrine; Promethazine
• Photosensitizing agents (topical)
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• Prazosin
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• Silodosin
• Simvastatin; Sitagliptin
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