Indacaterol Glycopyrrolate Brand Name– Utibron Neohaler
What is Indacaterol Glycopyrrolate
Indacaterol glycopyrrolate is a combination of indacaterol, a long-acting beta-2 adrenergic agonist (LABA), and glycopyrrolate, a long-acting muscarinic antagonist (LAMA).
The fixed-dose combination inhalation is used twice daily and is indicated for the maintenance treatment of airflow obstruction in adults with chronic obstructive pulmonary disease (COPD).
Treatment with indacaterol; glycopyrrolate also led to statistically and clinically meaningful improvements FEV1, improved health-related quality of life, and reduced use of rescue medication compared to placebo.
According to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines, indacaterol; glycopyrrolate may be used as initial therapy in group D (those with a high risk of exacerbation).
Combining bronchodilators with different mechanisms of action may further improve patient symptoms with a lower risk of adverse events compared to increasing the dose of a single bronchdilator. Combination bronchodilators have a greater impact on patient reported outcomes and quality of life compared to monotherapies.
Indacaterol glycopyrrolate is not indicated for the treatment of acute bronchospasm and is not to be used for the treatment of asthma.
Indacaterol glycopyrrolate was initially FDA-approved in 2015.
Indications
- chronic bronchitis
- chronic obstructive pulmonary disease (COPD)
- emphysema
For the maintenance treatment of chronic obstructive pulmonary disease (COPD), including chronic bronchitis and/or emphysema
Side Effects
- anaphylactoid reactions
- angioedema
- asthma-related death
- atrial fibrillation
- back pain
- blurred vision
- bronchospasm
- chest pain (unspecified)
- constipation
- cough
- diarrhea
- dizziness
- dyspepsia
- edema
- fatigue
- gastroesophageal reflux
- headache
- hyperglycemia
- hypertension
- hypokalemia
- infection
- insomnia
- ocular hypertension
- ocular pain
- palpitations
- pharyngitis
- pruritus
- QT prolongation
- rash
- rhinitis
- sinus tachycardia
- ST-T wave changes
- urinary retention
Monitoring Parameters
- pulmonary function tests (PFTs)
Contraindications
- acute bronchospasm
- alcoholism
- asthma
- asthma-related death
- bradycardia
- breast-feeding
- cardiac arrhythmias
- cardiac disease
- closed-angle glaucoma
- contact lenses
- coronary artery disease
- diabetes mellitus
- diabetic ketoacidosis
- females
- geriatric
- heart failure
- hepatic disease
- hyperglycemia
- hypertension
- hyperthyroidism
- hypocalcemia
- hypokalemia
- hypomagnesemia
- labor
- long QT syndrome
- malnutrition
- MAOI therapy
- milk protein hypersensitivity
- monotherapy treatment of asthma
- myocardial infarction
- obstetric delivery
- ocular exposure
- paradoxical bronchospasm
- pheochromocytoma
- pregnancy
- prostatic hypertrophy
- QT prolongation
- renal failure
- renal impairment
- seizure disorder
- seizures
- tachycardia
- thyrotoxicosis
- urinary retention
- urinary tract obstruction
Interactions
- Abarelix
- Acebutolol
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Diphenhydramine
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Pseudoephedrine
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