In which rheumatic diseases has PLEX been beneficial

In which rheumatic diseases has PLEX been beneficial?

  • • Thrombotic thrombocytopenia purpura (TTP) associated with rheumatic diseases.
  • • Catastrophic antiphospholipid syndrome.
  • • SLE: diffuse alveolar hemorrhage; neuropsychiatric lupus with coma; TTP.
  • • Neuromyelitis optica spectrum disorder.
  • • ANCA-associated vasculitis with diffuse alveolar hemorrhage and/or rapidly progressive crescentic glomerulonephritis (Cr >3.5; controversial).
  • • Hepatitis B-associated polyarteritis nodosa (combined with antiviral agent).
  • • Hepatitis C-associated cryoglobulinemia (combined with antiviral agent).
  • • Goodpasture syndrome with progressive renal failure and/or diffuse alveolar hemorrhage.
  • • PANDAS—pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections.
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