Ibuprofen Oxycodone Brand Name– Combunox
What is Ibuprofen Oxycodone
Oxycodone and ibuprofen are used together for the relief of acute pain. Ibuprofen is a nonsteroidal anti-inflammatory agent (NSAID) with analgesic and antipyretic effects.
Oxycodone is an oral semisynthetic opiate agonist derived from the opioid alkaloid, thebaine. In single dose studies, the combination of ibuprofen and oxycodone produced greater analgesia efficacy than placebo and each of the individual components as measured by the magnitude of pain relief and the reduction in pain intensity over 6 hours.
All NSAIDs carry an increased risk of serious gastrointestinal adverse effects including bleeding, ulceration, and perforation of the stomach or intestines and may cause an increased risk of serious cardiovascular (CV) thrombotic events, myocardial infarction, and stroke; prescribe at the lowest effective dose for the shortest possible duration.
On November 26, 2004 the FDA approved an ibuprofen; oxycodone combination product, Combunox (previously known as Oxyprofen), for the short-term treatment of moderate to severe pain.
Indications
- moderate pain
- severe pain
For the management of moderate pain to severe pain
Side Effects
- abdominal pain
- adrenocortical insufficiency
- agranulocytosis
- alopecia
- amblyopia
- amenorrhea
- anaphylactoid reactions
- anemia
- angioedema
- anxiety
- aplastic anemia
- aseptic meningitis
- asthenia
- azotemia
- back pain
- biliary obstruction
- blurred vision
- bullous rash
- chest pain (unspecified)
- chills
- colitis
- constipation
- cystitis
- diaphoresis
- diarrhea
- dizziness
- drowsiness
- dysgeusia
- dyspepsia
- dysphagia
- ecchymosis
- edema
- elevated hepatic enzymes
- eructation
- erythema multiforme
- esophageal stricture
- esophageal ulceration
- esophagitis
- euphoria
- exfoliative dermatitis
- fever
- flatulence
- fluid retention
- GI bleeding
- GI obstruction
- GI perforation
- gonadal suppression
- headache
- hearing loss
- heart failure
- hematuria
- hemolytic anemia
- hepatic failure
- hepatic necrosis
- hepatitis
- hyperkalemia
- hyperkinesis
- hypertension
- hypertonia
- hyperuricemia
- hypokalemia
- hypotension
- hypoxia
- ileus
- impotence (erectile dysfunction)
- increased urinary frequency
- infection
- infertility
- insomnia
- interstitial nephritis
- jaundice
- libido decrease
- maculopapular rash
- miosis
- myocardial infarction
- myoclonia
- nausea
- neonatal opioid withdrawal syndrome
- nephrotic syndrome
- neutropenia
- odynophagia
- pancreatitis
- pancytopenia
- peptic ulcer
- peripheral edema
- peripheral vasodilation
- pharyngitis
- phlebitis
- photophobia
- photosensitivity
- physiological dependence
- polyuria
- proteinuria
- pruritus
- psychological dependence
- pyrosis (heartburn)
- rash
- renal failure (unspecified)
- renal papillary necrosis
- respiratory depression
- serotonin syndrome
- SIADH
- sinus tachycardia
- Stevens-Johnson syndrome
- stroke
- syncope
- thrombocytopenia
- thromboembolism
- tinnitus
- tolerance
- toxic epidermal necrolysis
- urinary retention
- urticaria
- vasculitis
- visual impairment
- vomiting
- withdrawal
- xerostomia
Monitoring Parameters
- CBC
- LFTs
- serum creatinine/BUN
- serum electrolytes
Contraindications
- acute bronchospasm
- acute myocardial infarction
- adrenal insufficiency
- alcoholism
- angina
- anticoagulant therapy
- asthma
- biliary tract disease
- bladder obstruction
- bone marrow suppression
- brain tumor
- breast-feeding
- cardiac arrhythmias
- cardiac disease
- cerebrovascular disease
- chemotherapy
- children
- chronic obstructive pulmonary disease (COPD)
- coadministration with other CNS depressants
- coagulopathy
- coma
- constipation
- cor pulmonale
- coronary artery bypass graft surgery (CABG)
- coronary artery disease
- corticosteroid therapy
- dehydration
- dental disease
- dental work
- diabetes mellitus
- diarrhea
- driving or operating machinery
- edema
- geriatric
- GI bleeding
- GI disease
- GI obstruction
- GI perforation
- head trauma
- heart failure
- hematological disease
- hemophilia
- hepatic disease
- hypertension
- hypothyroidism
- hypovolemia
- hypoxemia
- ileus
- immunosuppression
- increased intracranial pressure
- infertility
- inflammatory bowel disease
- intramuscular injections
- jaundice
- labor
- myocardial infarction
- myxedema
- nasal polyps
- neonatal opioid withdrawal syndrome
- neutropenia
- NSAID hypersensitivity
- obesity
- obstetric delivery
- oliguria
- opiate agonist hypersensitivity
- pancreatitis
- peptic ulcer disease
- peripheral vascular disease
- pregnancy
- prostatic hypertrophy
- pulmonary disease
- renal disease
- renal failure
- renal impairment
- reproductive risk
- respiratory depression
- respiratory insufficiency
- rheumatoid arthritis
- salicylate hypersensitivity
- scoliosis
- seizure disorder
- shock
- sleep apnea
- status asthmaticus
- stroke
- substance abuse
- surgery
- systemic lupus erythematosus (SLE)
- tachycardia
- thrombocytopenia
- thromboembolism
- tobacco smoking
- ulcerative colitis
- urethral stricture
- urinary retention
- urticaria
Interactions
- Abciximab
- Acebutolol
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Diphenhydramine
- Acetaminophen; Hydrocodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Tramadol
- Acetohexamide
- Acrivastine; Pseudoephedrine
- Acyclovir
- Adefovir
- Aldesleukin, IL-2
- Alfentanil
- Aliskiren
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Aliskiren; Valsartan
- Almotriptan
- Alosetron
- Alpha-blockers
- Alprazolam
- Alteplase
- Altretamine
- Alvimopan
- Ambenonium Chloride
- Amide local anesthetics
- Amifampridine
- Amikacin
- Amiloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Aminolevulinic Acid
- Aminosalicylate sodium, Aminosalicylic acid
- Amiodarone
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amoxapine
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amphetamine
- Amphetamine; Dextroamphetamine
- Amphetamines
- Amphotericin B
- Amphotericin B cholesteryl sulfate complex (ABCD)
- Amphotericin B lipid complex (ABLC)
- Amphotericin B liposomal (LAmB)
- Anagrelide
- Angiotensin II receptor antagonists
- Angiotensin-converting enzyme inhibitors
- Anticholinergics
- Antithrombin III
- Antithymocyte Globulin
- Apalutamide
- Apixaban
- Apomorphine
- Apraclonidine
- Aprepitant, Fosaprepitant
- Aprotinin
- Argatroban
- Aripiprazole
- Armodafinil
- Arsenic Trioxide
- Articaine; Epinephrine
- Asenapine
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atazanavir
- Atazanavir; Cobicistat
- Atenolol
- Atenolol; Chlorthalidone
- Atomoxetine
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Atropine; Edrophonium
- Azathioprine
- Azelastine
- Azelastine; Fluticasone
- Azilsartan
- Azilsartan; Chlorthalidone
- Bacitracin
- Baclofen
- Barbiturates
- Beclomethasone
- Belladonna; Opium
- Benazepril
- Benazepril; Hydrochlorothiazide, HCTZ
- Bendamustine
- Bendroflumethiazide; Nadolol
- Benzhydrocodone; Acetaminophen
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Benzonatate
- Benzphetamine
- Beta-blockers
- Betamethasone
- Betaxolol
- Bethanechol
- Betrixaban
- Bexarotene
- Bicalutamide
- Bictegravir; Emtricitabine; Tenofovir Alafenamide
- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
- Bismuth Subsalicylate
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Bisoprolol
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Bisphosphonates
- Bivalirudin
- Bleomycin
- Boceprevir
- Bosentan
- Brexpiprazole
- Brigatinib
- Brimonidine
- Brimonidine; Brinzolamide
- Brimonidine; Timolol
- Brompheniramine
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Dextromethorphan; Guaifenesin
- Brompheniramine; Dextromethorphan; Phenylephrine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Budesonide
- Budesonide; Formoterol
- Bumetanide
- Bupivacaine
- Bupivacaine Liposomal
- Bupivacaine; Lidocaine
- Buprenorphine
- Buprenorphine; Naloxone
- Bupropion
- Bupropion; Naltrexone
- Buspirone
- Busulfan
- Butorphanol
- Calcium Phosphate, Supersaturated
- Calcium-channel blockers
- Candesartan
- Candesartan; Hydrochlorothiazide, HCTZ
- Cannabidiol
- Capecitabine
- Capreomycin
- Capsaicin; Metaxalone
- Captopril
- Captopril; Hydrochlorothiazide, HCTZ
- Carbamazepine
- Carbetapentane; Chlorpheniramine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbetapentane; Pyrilamine
- Carbinoxamine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Cardiac glycosides
- Cariprazine
- Carisoprodol
- Carmustine, BCNU
- Carteolol
- Carvedilol
- Cefotaxime
- Celecoxib
- Cenobamate
- Ceritinib
- Cetirizine
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexbrompheniramine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chloral Hydrate
- Chlorambucil
- Chloramphenicol
- Chlorcyclizine
- Chlordiazepoxide
- Chlordiazepoxide; Clidinium
- Chloroprocaine
- Chlorothiazide
- Chlorpheniramine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Chlorpromazine
- Chlorpropamide
- Chlorthalidone
- Chlorthalidone; Clonidine
- Chlorzoxazone
- Cholestyramine
- Choline Salicylate; Magnesium Salicylate
- Cholinesterase inhibitors
- Ciclesonide
- Cidofovir
- Cilostazol
- Cimetidine
- Ciprofloxacin
- Citalopram
- Cladribine
- Clarithromycin
- Clemastine
- Clobazam
- Clofarabine
- Clomipramine
- Clonazepam
- Clonidine
- Clopidogrel
- Clorazepate
- Clozapine
- Cobicistat
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Colchicine; Probenecid
- Colistimethate, Colistin, Polymyxin E
- COMT inhibitors
- Conivaptan
- Conjugated Estrogens; Bazedoxifene
- Corticosteroids
- Cortisone
- Crizotinib
- Crofelemer
- Cyclizine
- Cyclobenzaprine
- Cyclosporine
- Cyproheptadine
- Cytarabine, ARA-C
- Dabigatran
- Dabrafenib
- Dacarbazine, DTIC
- Dactinomycin, Actinomycin D
- Dalfopristin; Quinupristin
- Dalteparin
- Danaparoid
- Danazol
- Dantrolene
- Darifenacin
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Dasatinib
- Decitabine
- Deferasirox
- Deflazacort
- Delavirdine
- Denileukin Diftitox
- Desflurane
- Desipramine
- Desirudin
- Desmopressin
- Desvenlafaxine
- Deutetrabenazine
- Dexamethasone
- Dexchlorpheniramine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmedetomidine
- Dexpanthenol
- Dextroamphetamine
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Diazepam
- Diazoxide
- Dichlorphenamide
- Diclofenac
- Diclofenac; Misoprostol
- Diflunisal
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diltiazem
- Dimenhydrinate
- Diphenhydramine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Diphenhydramine; Phenylephrine
- Dipyridamole
- Docetaxel
- Dolasetron
- Donepezil
- Donepezil; Memantine
- Doravirine; Lamivudine; Tenofovir disoproxil fumarate
- Dorzolamide; Timolol
- Doxazosin
- Doxepin
- Doxylamine
- Doxylamine; Pyridoxine
- Dronabinol
- Dronedarone
- Droperidol
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Drotrecogin Alfa
- Duloxetine
- Duvelisib
- Edoxaban
- Edrophonium
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elagolix
- Elagolix; Estradiol; Norethindrone acetate
- Elbasvir; Grazoprevir
- Eletriptan
- Elexacaftor; tezacaftor; ivacaftor
- Eliglustat
- Eltrombopag
- Eluxadoline
- Elvitegravir
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Emtricitabine
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Emtricitabine; Tenofovir alafenamide
- Emtricitabine; Tenofovir disoproxil fumarate
- Enalapril, Enalaprilat
- Enalapril; Felodipine
- Enalapril; Hydrochlorothiazide, HCTZ
- Enflurane
- Enoxaparin
- Entecavir
- Enzalutamide
- Eplerenone
- Epoprostenol
- Eprosartan
- Eprosartan; Hydrochlorothiazide, HCTZ
- Eptifibatide
- Eribulin
- Erlotinib
- Erythromycin
- Erythromycin; Sulfisoxazole
- Escitalopram
- Esketamine
- Eslicarbazepine
- Esmolol
- Esomeprazole; Naproxen
- Estazolam
- Estramustine
- Eszopiclone
- Ethacrynic Acid
- Ethanol
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Etodolac
- Etomidate
- Etravirine
- Everolimus
- Fedratinib
- Fenfluramine
- Fenofibric Acid
- Fenoldopam
- Fenoprofen
- Fentanyl
- Fesoterodine
- Flavocoxid, Flavocoxid; Citrated Zinc Bisglycinate
- Flibanserin
- Floxuridine
- Fluconazole
- Fludarabine
- Fludrocortisone
- Flunisolide
- Fluorouracil, 5-FU
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluphenazine
- Flurazepam
- Flurbiprofen
- Fluticasone
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Fluvoxamine
- Fondaparinux
- food
- Formoterol; Mometasone
- Fosamprenavir
- Foscarnet
- Fosinopril
- Fosinopril; Hydrochlorothiazide, HCTZ
- Fosphenytoin
- Fospropofol
- Fostamatinib
- Frovatriptan
- Furosemide
- Gabapentin
- Gadoterate meglumine
- Galantamine
- Gallium Ga 68 Dotatate
- Ganciclovir
- Garlic, Allium sativum
- Gefitinib
- General anesthetics
- Gentamicin
- Ginger, Zingiber officinale
- Ginkgo, Ginkgo biloba
- Glimepiride
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- Glipizide
- Glipizide; Metformin
- Glyburide
- Glyburide; Metformin
- Gold
- Granisetron
- grapefruit juice
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guanabenz
- Guanfacine
- Haloperidol
- Halothane
- Heparin
- Homatropine; Hydrocodone
- Hyaluronidase, Recombinant; Immune Globulin
- Hydralazine
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydralazine; Isosorbide Dinitrate, ISDN
- Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydrocortisone
- Hydromorphone
- Hydroxyzine
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibritumomab Tiuxetan
- Ibuprofen lysine
- Idelalisib
- Iloperidone
- Iloprost
- Imatinib
- Imipramine
- Immune Globulin IV, IVIG, IGIV
- Indapamide
- Indinavir
- Indomethacin
- Inotersen
- Interferon Alfa-2a
- Interferon Alfa-2b
- Interferon Alfa-2b; Ribavirin
- Iodipamide Meglumine
- Iohexol
- Ionic Contrast Media
- Iopamidol
- Iopromide
- Ioversol
- Ioxaglate Meglumine; Ioxaglate Sodium
- Irbesartan
- Isavuconazonium
- Isoflurane
- Isoniazid, INH
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Isosulfan Blue
- Istradefylline
- Itraconazole
- Ivacaftor
- Ixabepilone
- Kanamycin
- Ketamine
- Ketoconazole
- Ketoprofen
- Ketorolac
- Labetalol
- Lamivudine; Tenofovir Disoproxil Fumarate
- Lansoprazole; Naproxen
- Lapatinib
- Larotrectinib
- Lasmiditan
- Lefamulin
- Leflunomide
- Lemborexant
- Lepirudin
- Lesinurad
- Lesinurad; Allopurinol
- Letermovir
- Levobetaxolol
- Levobunolol
- Levobupivacaine
- Levocetirizine
- Levomefolate
- Levomilnacipran
- Levorphanol
- Lidocaine
- Lidocaine; Prilocaine
- Lincosamides
- Linezolid
- Lisdexamfetamine
- Lisinopril
- Lithium
- Lofexidine
- Lomustine, CCNU
- Loop diuretics
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Lorazepam
- Lorcaserin
- Lorlatinib
- Losartan
- Loxapine
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Lumateperone
- Lurasidone
- Macimorelin
- Magnesium Salicylate
- Magnesium Salts
- Magnesium Sulfate; Potassium Sulfate; Sodium Sulfate
- Mannitol
- Maprotiline
- Mecamylamine
- Mechlorethamine, Nitrogen Mustard
- Meclofenamate Sodium
- Mefenamic Acid
- Melatonin
- Meloxicam
- Melphalan
- Meperidine
- Meperidine; Promethazine
- Mepivacaine
- Mepivacaine; Levonordefrin
- Meprobamate
- Mesalamine, 5-ASA
- Mesoridazine
- Metaxalone
- Methadone
- Methamphetamine
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methocarbamol
- Methotrexate
- Methoxsalen
- Methyclothiazide
- Methyldopa
- Methylene Blue
- Methylphenidate
- Methylprednisolone
- Methylsulfonylmethane, MSM
- Metoclopramide
- Metolazone
- Metoprolol
- Metyrapone
- Metyrosine
- Midazolam
- Mifepristone
- Milnacipran
- Minocycline
- Minoxidil
- Mirabegron
- Mirtazapine
- Mitomycin
- Mitotane
- Mitoxantrone
- Modafinil
- Moexipril
- Molindone
- Mometasone
- Monoamine oxidase inhibitors
- Morphine
- Morphine; Naltrexone
- Nabilone
- Nabumetone
- Nadolol
- Nafcillin
- Nalbuphine
- Naloxone
- Naltrexone
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Naratriptan
- Nebivolol
- Nebivolol; Valsartan
- Nefazodone
- Nelarabine
- Nelfinavir
- Neomycin
- Neostigmine
- Nesiritide, BNP
- Netupitant, Fosnetupitant; Palonosetron
- Nevirapine
- Nicardipine
- Nilotinib
- Nitroglycerin
- Nitroprusside
- Non-Ionic Contrast Media
- Nortriptyline
- Octreotide
- Olanzapine
- Olmesartan
- Omacetaxine
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Ondansetron
- Oritavancin
- Orphenadrine
- Osilodrostat
- Oxaprozin
- Oxazepam
- Oxcarbazepine
- Oxymorphone
- Ozanimod
- Paclitaxel
- Palbociclib
- Paliperidone
- Palonosetron
- Papaverine
- Paroxetine
- Pazopanib
- Pegaspargase
- Peginterferon Alfa-2b
- Pegvisomant
- Pemetrexed
- Penbutolol
- Pentamidine
- Pentazocine
- Pentazocine; Naloxone
- Pentosan
- Pentostatin
- Perampanel
- Perindopril
- Perindopril; Amlodipine
- Perphenazine
- Perphenazine; Amitriptyline
- Pexidartinib
- Phenothiazines
- Phenoxybenzamine
- Phentermine; Topiramate
- Phentolamine
- Phenylephrine; Promethazine
- Phenytoin
- Photosensitizing agents (topical)
- Physostigmine
- Pimozide
- Pindolol
- Piroxicam
- Platelet Inhibitors
- Pneumococcal Vaccine, Polyvalent
- Polyethylene Glycol; Electrolytes
- Polyethylene Glycol; Electrolytes; Ascorbic Acid
- Polymyxin B
- Polymyxins
- Posaconazole
- Potassium
- Pralatrexate
- Pramipexole
- Pramlintide
- Prasugrel
- Prazosin
- Prednisolone
- Prednisone
- Pregabalin
- Prilocaine
- Prilocaine; Epinephrine
- Probenecid
- Procaine
- Procarbazine
- Prochlorperazine
- Promethazine
- Propafenone
- Propofol
- Propoxyphene
- Propranolol
- Protriptyline
- Pyridostigmine
- Quazepam
- Quetiapine
- Quinapril
- Quinidine
- Quinine
- Quinolones
- Ramelteon
- Ramipril
- Ranolazine
- Rasagiline
- Remifentanil
- Reserpine
- Reteplase, r-PA
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
- Rifampin
- Rifapentine
- Rifaximin
- Riluzole
- Risperidone
- Ritonavir
- Rivaroxaban
- Rivastigmine
- Rizatriptan
- Rolapitant
- Romidepsin
- Ropinirole
- Ropivacaine
- Rotigotine
- Rucaparib
- Sacubitril; Valsartan
- Safinamide
- Salicylates
- Salsalate
- Saquinavir
- Selective norepinephrine reuptake inhibitors
- Selective serotonin reuptake inhibitors
- Selegiline
- Selpercatinib
- Serotonin norepinephrine reuptake inhibitors
- Serotonin-Receptor Agonists
- Serotonin-Receptor Antagonists
- Sertraline
- Sevoflurane
- Sibutramine
- Sildenafil
- Simeprevir
- Sodium Hyaluronate, Hyaluronic Acid
- Sodium Oxybate
- Sodium Phosphate Monobasic Monohydrate; Sodium Phosphate Dibasic Anhydrous
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Solifenacin
- Sotalol
- Spironolactone
- St. John’s Wort, Hypericum perforatum
- Streptogramins
- Streptokinase
- Streptomycin
- Streptozocin
- Sulfinpyrazone
- Sulfonylureas
- Sulindac
- Sumatriptan
- Suvorexant
- Tacrine
- Tacrolimus
- Tapentadol
- Tasimelteon
- Tedizolid
- Telaprevir
- Telavancin
- Telbivudine
- Telithromycin
- Telmisartan
- Telotristat Ethyl
- Temazepam
- Temozolomide
- Tenecteplase
- Teniposide
- Tenofovir Alafenamide
- Tenofovir, PMPA
- Terazosin
- Terbinafine
- Tetrabenazine
- Tetracaine
- Tezacaftor; Ivacaftor
- Thalidomide
- Thiazide diuretics
- Thiethylperazine
- Thioguanine, 6-TG
- Thioridazine
- Thiothixene
- Thrombolytic Agents
- Ticagrelor
- Ticlopidine
- Timolol
- Tinzaparin
- Tipranavir
- Tirofiban
- Tizanidine
- tobacco
- Tobramycin
- Tolazamide
- Tolbutamide
- Tolmetin
- Tolterodine
- Topiramate
- Torsemide
- Tositumomab
- Tramadol
- Trandolapril
- Trandolapril; Verapamil
- Trazodone
- Treprostinil
- Tretinoin, ATRA
- Triamcinolone
- Triamterene
- Triazolam
- Tricyclic antidepressants
- Trifluoperazine
- Trimethobenzamide
- Trimipramine
- Triprolidine
- Trospium
- Tucatinib
- Urea
- Urokinase
- Valacyclovir
- Valerian, Valeriana officinalis
- Valganciclovir
- Valproic Acid, Divalproex Sodium
- Valsartan
- Vancomycin
- Vasodilators
- Vemurafenib
- Venlafaxine
- Verapamil
- Verteporfin
- Vigabatrin
- Vilazodone
- Vincristine
- Vincristine Liposomal
- Vorapaxar
- Voriconazole
- Vorinostat
- Vortioxetine
- Voxelotor
- Warfarin
- Zafirlukast
- Zaleplon
- Ziconotide
- Ziprasidone
- Zolmitriptan
- Zolpidem
