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Hydroxychloroquine Brand Names- Plaquenil | Quineprox
What is Hydroxychloroquine
Hydroxychloroquine is an oral disease-modifying antirheumatic drug (DMARD) used to treat rheumatoid arthritis and systemic lupus erythematosus.
It also is used to prevent and treat malaria. Irreversible retinal damage has been observed with use, and postmarketing cases of life-threatening and fatal cardiomyopathy, including ventricular arrhythmias and torsade de pointes, have been reported.
Hydroxychloroquine was FDA-approved in 1955.
Indications
- coronavirus disease 2019 (COVID-19)
- discoid lupus erythematosus
- lupus nephritis
- malaria
- malaria prophylaxis
- Plasmodium falciparum
- Plasmodium malariae
- Plasmodium ovale
- Plasmodium vivax
- polymorphous light eruption
- rheumatoid arthritis
- severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
- severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection
- systemic lupus erythematosus (SLE)
Side Effects
- abdominal pain
- acute generalized exanthematous pustulosis (AGEP)
- agranulocytosis
- alopecia
- anemia
- angioedema
- anorexia
- aplastic anemia
- ataxia
- AV block
- blurred vision
- bronchospasm
- bullous rash
- bundle-branch block
- cardiomyopathy
- corneal deposits
- corneal edema
- corneal opacification
- diarrhea
- dizziness
- Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
- dyskinesia
- dystonic reaction
- emotional lability
- erythema multiforme
- exfoliative dermatitis
- fatigue
- hair discoloration
- headache
- hearing loss
- heart failure
- hemolysis
- hepatic failure
- hypoglycemia
- irritability
- leukopenia
- macular degeneration
- myopathy
- nausea
- nightmares
- nystagmus
- photophobia
- photosensitivity
- porphyria
- pruritus
- psoriasis
- psychosis
- pulmonary hypertension
- QT prolongation
- rash
- retinal pigment changes
- retinopathy
- scotomata
- seizures
- skin discoloration
- Stevens-Johnson syndrome
- suicidal ideation
- thrombocytopenia
- tinnitus
- torsade de pointes
- toxic epidermal necrolysis
- tremor
- urticaria
- ventricular fibrillation
- ventricular tachycardia
- vertigo
- visual impairment
- vomiting
- weakness
- weight loss
Monitoring Parameters
- blood glucose
- CBC
- ECG
- glucose-6-phosphate dehydrogenase (G6PD) activity
- ophthalmologic exam
Contraindications
- accidental exposure
- alcoholism
- apheresis
- Asian patients
- AV block
- bradycardia
- breast-feeding
- cardiomyopathy
- celiac disease
- children
- diabetes mellitus
- females
- fever
- G6PD deficiency
- geriatric
- GI disease
- heart failure
- hepatic disease
- human immunodeficiency virus (HIV) infection
- hyperparathyroidism
- hypocalcemia
- hypoglycemia
- hypokalemia
- hypomagnesemia
- hypothermia
- hypothyroidism
- infants
- long QT syndrome
- myocardial infarction
- myopathy
- neonates
- neurological disease
- ocular disease
- pheochromocytoma
- porphyria
- pregnancy
- psoriasis
- QT prolongation
- renal disease
- rheumatoid arthritis
- sickle cell disease
- sleep deprivation
- stroke
- systemic lupus erythematosus (SLE)
- visual disturbance
Interactions
- Acarbose
- Acetazolamide
- Acetohexamide
- Aclidinium; Formoterol
- Albiglutide
- Albuterol
- Albuterol; Ipratropium
- Alfuzosin
- Alogliptin
- Alogliptin; Metformin
- Alogliptin; Pioglitazone
- Alpha-glucosidase Inhibitors
- Amiodarone
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amobarbital
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Ampicillin
- Anagrelide
- Antacids
- Apomorphine
- Arformoterol
- Aripiprazole
- Arsenic Trioxide
- Artemether; Lumefantrine
- Asenapine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Atomoxetine
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Azithromycin
- Bedaquiline
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Betrixaban
- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Brivaracetam
- Budesonide; Formoterol
- Buprenorphine
- Buprenorphine; Naloxone
- Calcium Carbonate
- Calcium Carbonate; Magnesium Hydroxide
- Calcium Carbonate; Risedronate
- Calcium Carbonate; Simethicone
- Canagliflozin
- Canagliflozin; Metformin
- Carbamazepine
- Ceritinib
- Chlorpromazine
- Chlorpropamide
- Cimetidine
- Ciprofloxacin
- Cisapride
- Citalopram
- Clarithromycin
- Clobazam
- Clofazimine
- Clomipramine
- Clonazepam
- Clorazepate
- Clozapine
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Crizotinib
- Cyclosporine
- Dabigatran
- Dapagliflozin
- Dapagliflozin; Metformin
- Dapagliflozin; Saxagliptin
- Dasatinib
- Degarelix
- Desflurane
- Desipramine
- Deutetrabenazine
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Diazepam
- Digoxin
- Dipeptidyl Peptidase-4 Inhibitors
- Disopyramide
- Dofetilide
- Dolasetron
- Dolutegravir; Rilpivirine
- Donepezil
- Donepezil; Memantine
- Doxepin
- Dronedarone
- Droperidol
- Dulaglutide
- Edoxaban
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Eliglustat
- Empagliflozin
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Encorafenib
- Enflurane
- Entrectinib
- Eribulin
- Ertugliflozin
- Ertugliflozin; Metformin
- Ertugliflozin; Sitagliptin
- Erythromycin
- Erythromycin; Sulfisoxazole
- Escitalopram
- Eslicarbazepine
- Ethosuximide
- Ethotoin
- Exenatide
- Ezogabine
- Felbamate
- Fingolimod
- Flecainide
- Fluconazole
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluphenazine
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Fluvoxamine
- Formoterol
- Formoterol; Mometasone
- Foscarnet
- Fosphenytoin
- Gabapentin
- Gemifloxacin
- Gemtuzumab Ozogamicin
- Gilteritinib
- Glasdegib
- Glimepiride
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- Glipizide
- Glipizide; Metformin
- Glyburide
- Glyburide; Metformin
- Glycopyrrolate; Formoterol
- Goserelin
- Granisetron
- Halogenated Anesthetics
- Haloperidol
- Halothane
- Histrelin
- Hydroxyzine
- Ibutilide
- Iloperidone
- Imipramine
- Incretin Mimetics
- Indacaterol
- Indacaterol; Glycopyrrolate
- Inotuzumab Ozogamicin
- Insulin Aspart
- Insulin Aspart; Insulin Aspart Protamine
- Insulin Degludec
- Insulin Degludec; Liraglutide
- Insulin Detemir
- Insulin Glargine
- Insulin Glargine; Lixisenatide
- Insulin Glulisine
- Insulin Lispro
- Insulin Lispro; Insulin Lispro Protamine
- Insulin, Inhaled
- Insulins
- Isoflurane
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Isophane Insulin (NPH)
- Itraconazole
- Ivosidenib
- Ketoconazole
- Lacosamide
- Lamotrigine
- Lanthanum Carbonate
- Lapatinib
- Lefamulin
- Lente Insulin
- Lenvatinib
- Leuprolide
- Leuprolide; Norethindrone
- Levalbuterol
- Levetiracetam
- Levofloxacin
- Linagliptin
- Linagliptin; Metformin
- Liraglutide
- Lithium
- Lixisenatide
- Lofexidine
- Long-acting beta-agonists
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Lorazepam
- Macimorelin
- Maprotiline
- Mefloquine
- Meglitinides
- Meperidine; Promethazine
- Mephobarbital
- Metaproterenol
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methadone
- Methotrexate
- Methsuximide
- Metronidazole
- Midostaurin
- Mifepristone
- Miglitol
- Mirtazapine
- Moxifloxacin
- Nateglinide
- Nilotinib
- Norfloxacin
- Nortriptyline
- Octreotide
- Ofloxacin
- Olanzapine
- Olodaterol
- Omeprazole; Sodium Bicarbonate
- Ondansetron
- Osilodrostat
- Osimertinib
- Oxaliplatin
- Ozanimod
- Paliperidone
- Panobinostat
- Pasireotide
- Pazopanib
- Penicillamine
- Pentamidine
- Pentobarbital
- Perampanel
- Perphenazine
- Perphenazine; Amitriptyline
- Phenobarbital
- Phentermine; Topiramate
- Phenylephrine; Promethazine
- Phenytoin
- Pimavanserin
- Pimozide
- Pioglitazone
- Pirbuterol
- Pitolisant
- Posaconazole
- Pramlintide
- Praziquantel
- Pregabalin
- Primaquine
- Primidone
- Procainamide
- Prochlorperazine
- Promethazine
- Propafenone
- Protriptyline
- Quetiapine
- Quinidine
- Quinine
- Rabies Vaccine
- Ranolazine
- Regular Insulin
- Regular Insulin; Isophane Insulin (NPH)
- Remdesivir
- Repaglinide
- Ribociclib
- Ribociclib; Letrozole
- Rifampin
- Rilpivirine
- Risperidone
- Rituximab
- Rituximab; Hyaluronidase
- Romidepsin
- Rosiglitazone
- Rufinamide
- Salmeterol
- Saquinavir
- Saxagliptin
- Selpercatinib
- Semaglutide
- Sertraline
- Sevoflurane
- SGLT2 Inhibitors
- Short-acting beta-agonists
- Simvastatin; Sitagliptin
- Siponimod
- Sitagliptin
- Sodium Bicarbonate
- Solifenacin
- Sorafenib
- Sotalol
- Sulfonylureas
- Sunitinib
- Tacrolimus
- Tamoxifen
- Telavancin
- Telbivudine
- Telithromycin
- Terbutaline
- Tetrabenazine
- Thiazolidinediones
- Thioridazine
- Tiagabine
- Tiotropium; Olodaterol
- Tolazamide
- Tolbutamide
- Tolterodine
- Topiramate
- Toremifene
- Trazodone
- Tricyclic antidepressants
- Trifluoperazine
- Trimipramine
- Triptorelin
- Ultralente Insulin
- Umeclidinium; Vilanterol
- Valproic Acid, Divalproex Sodium
- Vandetanib
- Vardenafil
- Vemurafenib
- Venlafaxine
- Vigabatrin
- Voriconazole
- Vorinostat
- Ziprasidone
- Zonisamide
