Hydroxyethyl Starch

Hydroxyethyl Starch Brand Name– Voluven

What is Hydroxyethyl Starch

Hydroxyethyl starch (HES) is a hydroxyethyl synthetic colloidal starch. HES is used for the treatment of hypovolemia when plasma volume expansion is desired.

HES is derived from a waxy starch composed almost entirely of amylopectin.

The average molecular weight of HES is approximately 130,000 daltons.

HES was FDA-approved for the treatment of hypovolemia in December 2007.

Indications

  • hypovolemia

For use as a plasma volume substitute in the treatment and prophylaxis of hypovolemia

Side Effects

  1. anaphylactoid reactions
  2. bleeding
  3. bradycardia
  4. bronchospasm
  5. chills
  6. coagulopathy
  7. cough
  8. hyperamylasemia
  9. hypotension
  10. pruritus
  11. pulmonary edema
  12. renal failure (unspecified)
  13. sinus tachycardia
  14. sneezing

Monitoring Parameters

  • hemoglobin/hematocrit
  • platelet count
  • prothrombin time (PT)
  • serum creatinine/BUN
  • serum electrolytes

Contraindications

  • anuria
  • breast-feeding
  • cardiac disease
  • coagulopathy
  • dehydration
  • dialysis
  • geriatric
  • heart failure
  • hepatic disease
  • hydroxyethyl cellulose hypersensitivity
  • hyperchloremia
  • hypernatremia
  • hypervolemia
  • intracranial bleeding
  • labor
  • mortality
  • obstetric delivery
  • oliguria
  • pregnancy
  • pulmonary edema
  • renal disease
  • renal failure
  • sepsis
  • surgery
  • von Willebrand’s disease

Interactions

  • Azelastine; Fluticasone
  • Beclomethasone
  • Betamethasone
  • Budesonide
  • Budesonide; Formoterol
  • Ciclesonide
  • Corticosteroids
  • Cortisone
  • Deflazacort
  • Dexamethasone
  • Dichlorphenamide
  • Fludrocortisone
  • Flunisolide
  • Fluticasone
  • Fluticasone; Salmeterol
  • Fluticasone; Umeclidinium; Vilanterol
  • Fluticasone; Vilanterol
  • Formoterol; Mometasone
  • Hydrocortisone
  • Lithium
  • Methylprednisolone
  • Mometasone
  • Prednisolone
  • Prednisone
  • Tolvaptan
  • Triamcinolone
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