Hydrocodone bitartrate Ibuprofen

Hydrocodone bitartrate Ibuprofen Brand Names- Ibudone | Reprexain | Vicoprofen | Xylon 10

What is Hydrocodone Ibuprofen

Hydrocodone bitartrate and ibuprofen are used together for the relief of acute pain. Hydrocodone is a semisynthetic opioid analgesic and antitussive. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic effects.

All NSAIDs carry an increased risk of serious gastrointestinal adverse effects including bleeding, ulceration, and perforation of the stomach or intestines and may cause an increased risk of serious cardiovascular (CV) thrombotic events, myocardial infarction, and stroke.

The lowest effective ibuprofen dose for the shortest possible duration is recommended, as the risk for adverse effects may increase with duration of use.

The American Geriatrics Society recommends that NSAIDs (nonselective and COX-2 inhibitors) not be used to treat persistent pain in elderly patients except rarely, then only in patients who have failed other therapies and have a favorable benefits vs. risks assessment; extreme caution, continued therapy evaluation, and concurrent PPI or misoprostol is advised with ibuprofen use in this population.

In clinical trials, one tablet of the combination of hydrocodone and ibuprofen was as effective as two tablets of Tylenol No. 3 (acetaminophen 300 mg and codeine phosphate 30 mg) in relieving acute pain resulting from sprains/strains, surgery, back disorders, dental procedures, sport injuries, and fractures/dislocations.

The FDA approved hydrocodone; ibuprofen (Vicoprofen) 7.5 mg/200 mg tablets in October 1997, hydrocodone; ibuprofen 5 mg/200 mg tablets (Reprexain) in March 2004, hydrocodone; ibuprofen 2.5 mg/200 mg tablets (Reprexain) in October 2007, and hydrocodone; ibuprofen 10 mg/200 mg tablets (Ibudone) in January 2008.

Indications

• severe pain

For the treatment of short-term (generally less than 10 days) acute, severe pain that requires and opioid analgesic and for which alternative treatments are inadequate

Side Effects

1. abdominal pain
2. adrenocortical insufficiency
3. agitation
4. agranulocytosis
5. amenorrhea
6. angioedema
7. anorexia
8. anxiety
9. aplastic anemia
10. arthralgia
11. aseptic meningitis
12. asthenia
13. biliary obstruction
14. bleeding
15. blurred vision
16. bradycardia
17. bullous rash
18. confusion
19. constipation
20. cystitis
21. depression
22. diarrhea
23. dizziness
24. drowsiness
25. dysgeusia
26. dyspepsia
27. dysphagia
28. dyspnea
29. edema
30. elevated hepatic enzymes
31. esophagitis
32. euphoria
33. exfoliative dermatitis
34. fever
35. flatulence
36. flushing
37. gastritis
38. GI bleeding
39. GI obstruction
40. GI perforation
41. glossitis
42. glycosuria
43. gonadal suppression
44. headache
45. heart failure
46. hemolytic anemia
47. hepatic failure
48. hepatic necrosis
49. hepatitis
50. hiccups
51. hoarseness
52. hypertension
53. hypertonia
54. hyponatremia
55. hypotension
56. impotence (erectile dysfunction)
57. infection
58. infertility
59. interstitial nephritis
60. jaundice
61. libido decrease
62. maculopapular rash
63. melena
64. miosis
65. myalgia
66. myocardial infarction
67. nausea
68. neonatal opioid withdrawal syndrome
69. nephrotic syndrome
70. neutropenia
71. oral ulceration
72. orthostatic hypotension
73. palpitations
74. pancreatitis
75. pancytopenia
76. paresthesias
77. peptic ulcer
78. pharyngitis
79. photophobia
80. photosensitivity
81. physiological dependence
82. platelet dysfunction
83. pruritus
84. psychological dependence
85. pyrosis (heartburn)
86. rash
87. renal papillary necrosis
88. respiratory depression
89. rhinitis
90. serotonin syndrome
91. SIADH
92. sinus tachycardia
93. sinusitis
94. Stevens-Johnson syndrome
95. stroke
96. syncope
97. thrombocytopenia
98. thromboembolism
99. tinnitus
100. toxic epidermal necrolysis
101. tremor
102. urinary incontinence
103. urinary retention
104. urticaria
105. vasculitis
106. vertigo
107. visual impairment
108. vomiting
109. weight loss
110. withdrawal
111. xerophthalmia
112. xerostomia

Monitoring Parameters

• laboratory monitoring not necessary

Contraindications

• abrupt discontinuation
• accidental exposure
• acute myocardial infarction
• adrenal insufficiency
• alcoholism
• anemia
• angina
• anticoagulant therapy
• asthma
• biliary tract disease
• bladder obstruction
• bone marrow suppression
• breast-feeding
• cardiac arrhythmias
• cardiac disease
• cardiomyopathy
• chemotherapy
• chronic obstructive pulmonary disease (COPD)
• coadministration with other CNS depressants
• coagulopathy
• constipation
• coronary artery bypass graft surgery (CABG)
• coronary artery disease
• corticosteroid therapy
• dental disease
• dental work
• diabetes mellitus
• diarrhea
• driving or operating machinery
• edema
• geriatric
• GI bleeding
• GI disease
• GI obstruction
• GI perforation
• head trauma
• heart failure
• hematological disease
• hemophilia
• hepatic disease
• hypertension
• hypothyroidism
• ileus
• immunosuppression
• increased intracranial pressure
• infection
• infertility
• inflammatory bowel disease
• intramuscular injections
• jaundice
• labor
• myocardial infarction
• myxedema
• nasal polyps
• neonatal opioid withdrawal syndrome
• neutropenia
• NSAID hypersensitivity
• obstetric delivery
• oliguria
• opiate agonist hypersensitivity
• peptic ulcer disease
• peripheral vascular disease
• polysorbate 80 hypersensitivity
• potential for overdose or poisoning
• pregnancy
• prostatic hypertrophy
• pulmonary disease
• renal disease
• renal failure
• renal impairment
• reproductive risk
• respiratory depression
• respiratory insufficiency
• salicylate hypersensitivity
• seizure disorder
• sepsis
• status asthmaticus
• stroke
• substance abuse
• surgery
• systemic lupus erythematosus (SLE)
• tachycardia
• thrombocytopenia
• thromboembolism
• tobacco smoking
• ulcerative colitis
• urethral stricture
• urinary retention
• urticaria

Interactions

• Abciximab
• Abiraterone
• Acebutolol
• Acetaminophen; Aspirin, ASA; Caffeine
• Acetaminophen; Butalbital
• Acetaminophen; Butalbital; Caffeine
• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Caffeine; Dihydrocodeine
• Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
• Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
• Acetaminophen; Codeine
• Acetaminophen; Dextromethorphan; Doxylamine
• Acetaminophen; Dichloralphenazone; Isometheptene
• Acetaminophen; Diphenhydramine
• Acetaminophen; Oxycodone
• Acetaminophen; Pentazocine
• Acetaminophen; Propoxyphene
• Acetaminophen; Tramadol
• Acetohexamide
• Acrivastine; Pseudoephedrine
• Acyclovir
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• Brompheniramine; Pseudoephedrine
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• Carbetapentane; Phenylephrine
• Carbetapentane; Phenylephrine; Pyrilamine
• Carbetapentane; Pseudoephedrine
• Carbetapentane; Pyrilamine
• Carbinoxamine
• Carbinoxamine; Dextromethorphan; Pseudoephedrine
• Carbinoxamine; Hydrocodone; Phenylephrine
• Carbinoxamine; Hydrocodone; Pseudoephedrine
• Carbinoxamine; Phenylephrine
• Carbinoxamine; Pseudoephedrine
• Cardiac glycosides
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• Carmustine, BCNU
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• Carvedilol
• Castor Oil
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• Chloral Hydrate
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• Chloramphenicol
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• Chlordiazepoxide
• Chlordiazepoxide; Clidinium
• Chloroprocaine
• Chlorothiazide
• Chlorpheniramine
• Chlorpheniramine; Codeine
• Chlorpheniramine; Dextromethorphan
• Chlorpheniramine; Dextromethorphan; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
• Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Hydrocodone
• Chlorpheniramine; Hydrocodone; Phenylephrine
• Chlorpheniramine; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Phenylephrine
• Chlorpheniramine; Pseudoephedrine
• Chlorpromazine
• Chlorpropamide
• Chlorthalidone
• Chlorthalidone; Clonidine
• Chlorzoxazone
• Cholestyramine
• Choline Salicylate; Magnesium Salicylate
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• Codeine; Guaifenesin
• Codeine; Phenylephrine; Promethazine
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• Dronabinol
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• Nabilone
• Nabumetone
• Nadolol
• Nafcillin
• Nalbuphine
• Naloxone
• Naltrexone
• Naproxen
• Naproxen; Pseudoephedrine
• Naproxen; Sumatriptan
• Naratriptan
• Nebivolol
• Nebivolol; Valsartan
• Nefazodone
• Nelarabine
• Nelfinavir
• Neomycin
• Neostigmine
• Nesiritide, BNP
• Netupitant, Fosnetupitant; Palonosetron
• Nevirapine
• Nicardipine
• Nilotinib
• Nitroglycerin
• Nitroprusside
• Non-Ionic Contrast Media
• Olanzapine
• Olmesartan
• Omacetaxine
• Ombitasvir; Paritaprevir; Ritonavir
• Omeprazole; Amoxicillin; Rifabutin
• Ondansetron
• Oritavancin
• Orphenadrine
• Osilodrostat
• Oxaprozin
• Oxazepam
• Oxcarbazepine
• Oxybutynin
• Oxycodone
• Oxymorphone
• Ozanimod
• Paclitaxel
• Palbociclib
• Paliperidone
• Palonosetron
• Panobinostat
• Papaverine
• Paroxetine
• Pazopanib
• Pegaspargase
• Peginterferon Alfa-2b
• Pegvisomant
• Pemetrexed
• Penbutolol
• Pentamidine
• Pentazocine
• Pentazocine; Naloxone
• Pentobarbital
• Pentosan
• Pentostatin
• Perampanel
• Perindopril
• Perindopril; Amlodipine
• Perphenazine
• Perphenazine; Amitriptyline
• Pexidartinib
• Phenelzine
• Phenobarbital
• Phenoxybenzamine
• Phentermine; Topiramate
• Phentolamine
• Phenylephrine; Promethazine
• Phenytoin
• Photosensitizing agents (topical)
• Physostigmine
• Pimozide
• Pindolol
• Piroxicam
• Platelet Inhibitors
• Pneumococcal Vaccine, Polyvalent
• Polyethylene Glycol
• Polyethylene Glycol; Electrolytes
• Polyethylene Glycol; Electrolytes; Ascorbic Acid
• Polyethylene Glycol; Electrolytes; Bisacodyl
• Polymyxin B
• Polymyxins
• Posaconazole
• Potassium
• Pralatrexate
• Pramipexole
• Pramlintide
• Prasugrel
• Prazosin
• Prednisolone
• Prednisone
• Pregabalin
• Prilocaine
• Prilocaine; Epinephrine
• Primidone
• Probenecid
• Procaine
• Procarbazine
• Prochlorperazine
• Promethazine
• Propafenone
• Propantheline
• Propofol
• Propoxyphene
• Propranolol
• Pyridostigmine
• Quazepam
• Quetiapine
• Quinapril
• Quinidine
• Quinine
• Quinolones
• Ramelteon
• Ramipril
• Ranolazine
• Rasagiline
• Remifentanil
• Reserpine
• Reteplase, r-PA
• Ribociclib
• Ribociclib; Letrozole
• Rifabutin
• Rifampin
• Rifapentine
• Rifaximin
• Riluzole
• Risperidone
• Ritonavir
• Rivaroxaban
• Rivastigmine
• Rizatriptan
• Rolapitant
• Romidepsin
• Ropinirole
• Ropivacaine
• Rotigotine
• Rucaparib
• Sacubitril; Valsartan
• Safinamide
• Salicylates
• Salsalate
• Saquinavir
• Scopolamine
• Secobarbital
• Selective serotonin reuptake inhibitors
• Selegiline
• Selpercatinib
• Serotonin-Receptor Agonists
• Serotonin-Receptor Antagonists
• Sertraline
• Sevoflurane
• Sibutramine
• Sildenafil
• Simeprevir
• Skeletal Muscle Relaxants
• Sodium Hyaluronate, Hyaluronic Acid
• Sodium Oxybate
• Sodium Phosphate Monobasic Monohydrate; Sodium Phosphate Dibasic Anhydrous
• Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
• Solifenacin
• Sorbitol
• Sotalol
• Spironolactone
• St. John’s Wort, Hypericum perforatum
• Streptogramins
• Streptokinase
• Streptomycin
• Streptozocin
• Sufentanil
• Sulfinpyrazone
• Sulfonylureas
• Sulindac
• Sumatriptan
• Suvorexant
• Tacrine
• Tacrolimus
• Tapentadol
• Tasimelteon
• Tazemetostat
• Tedizolid
• Telaprevir
• Telavancin
• Telbivudine
• Telithromycin
• Telmisartan
• Telotristat Ethyl
• Temazepam
• Temozolomide
• Tenecteplase
• Teniposide
• Tenofovir Alafenamide
• Tenofovir, PMPA
• Terazosin
• Terbinafine
• Tetrabenazine
• Tetracaine
• Tezacaftor; Ivacaftor
• Thalidomide
• Thiazide diuretics
• Thioguanine, 6-TG
• Thiopental
• Thioridazine
• Thiothixene
• Thrombolytic Agents
• Ticagrelor
• Ticlopidine
• Timolol
• Tinzaparin
• Tipranavir
• Tirofiban
• Tizanidine
• tobacco
• Tobramycin
• Tolazamide
• Tolbutamide
• Tolmetin
• Tolterodine
• Topiramate
• Torsemide
• Tositumomab
• Tramadol
• Trandolapril
• Trandolapril; Verapamil
• Tranylcypromine
• Trazodone
• Treprostinil
• Tretinoin, ATRA
• Triamcinolone
• Triamterene
• Triazolam
• Tricyclic antidepressants
• Trifluoperazine
• Trihexyphenidyl
• Trimethobenzamide
• Triprolidine
• Trospium
• Tucatinib
• Urea
• Urokinase
• Valacyclovir
• Valerian, Valeriana officinalis
• Valganciclovir
• Valproic Acid, Divalproex Sodium
• Valsartan
• Vancomycin
• Vasodilators
• Vemurafenib
• Venlafaxine
• Verapamil
• Verteporfin
• Vigabatrin
• Vilazodone
• Vincristine
• Vincristine Liposomal
• Vorapaxar
• Voriconazole
• Vorinostat
• Vortioxetine
• Voxelotor
• Warfarin
• Zafirlukast
• Zaleplon
• Ziconotide
• Ziprasidone
• Zolmitriptan
• Zolpidem