Hydrocodone bitartrate Ibuprofen Brand Names- Ibudone | Reprexain | Vicoprofen | Xylon 10
What is Hydrocodone Ibuprofen
Hydrocodone bitartrate and ibuprofen are used together for the relief of acute pain. Hydrocodone is a semisynthetic opioid analgesic and antitussive. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic effects.
All NSAIDs carry an increased risk of serious gastrointestinal adverse effects including bleeding, ulceration, and perforation of the stomach or intestines and may cause an increased risk of serious cardiovascular (CV) thrombotic events, myocardial infarction, and stroke.
The lowest effective ibuprofen dose for the shortest possible duration is recommended, as the risk for adverse effects may increase with duration of use.
The American Geriatrics Society recommends that NSAIDs (nonselective and COX-2 inhibitors) not be used to treat persistent pain in elderly patients except rarely, then only in patients who have failed other therapies and have a favorable benefits vs. risks assessment; extreme caution, continued therapy evaluation, and concurrent PPI or misoprostol is advised with ibuprofen use in this population.
In clinical trials, one tablet of the combination of hydrocodone and ibuprofen was as effective as two tablets of Tylenol No. 3 (acetaminophen 300 mg and codeine phosphate 30 mg) in relieving acute pain resulting from sprains/strains, surgery, back disorders, dental procedures, sport injuries, and fractures/dislocations.
The FDA approved hydrocodone; ibuprofen (Vicoprofen) 7.5 mg/200 mg tablets in October 1997, hydrocodone; ibuprofen 5 mg/200 mg tablets (Reprexain) in March 2004, hydrocodone; ibuprofen 2.5 mg/200 mg tablets (Reprexain) in October 2007, and hydrocodone; ibuprofen 10 mg/200 mg tablets (Ibudone) in January 2008.
Indications
- severe pain
For the treatment of short-term (generally less than 10 days) acute, severe pain that requires and opioid analgesic and for which alternative treatments are inadequate
Side Effects
- abdominal pain
- adrenocortical insufficiency
- agitation
- agranulocytosis
- amenorrhea
- angioedema
- anorexia
- anxiety
- aplastic anemia
- arthralgia
- aseptic meningitis
- asthenia
- biliary obstruction
- bleeding
- blurred vision
- bradycardia
- bullous rash
- confusion
- constipation
- cystitis
- depression
- diarrhea
- dizziness
- drowsiness
- dysgeusia
- dyspepsia
- dysphagia
- dyspnea
- edema
- elevated hepatic enzymes
- esophagitis
- euphoria
- exfoliative dermatitis
- fever
- flatulence
- flushing
- gastritis
- GI bleeding
- GI obstruction
- GI perforation
- glossitis
- glycosuria
- gonadal suppression
- headache
- heart failure
- hemolytic anemia
- hepatic failure
- hepatic necrosis
- hepatitis
- hiccups
- hoarseness
- hypertension
- hypertonia
- hyponatremia
- hypotension
- impotence (erectile dysfunction)
- infection
- infertility
- interstitial nephritis
- jaundice
- libido decrease
- maculopapular rash
- melena
- miosis
- myalgia
- myocardial infarction
- nausea
- neonatal opioid withdrawal syndrome
- nephrotic syndrome
- neutropenia
- oral ulceration
- orthostatic hypotension
- palpitations
- pancreatitis
- pancytopenia
- paresthesias
- peptic ulcer
- pharyngitis
- photophobia
- photosensitivity
- physiological dependence
- platelet dysfunction
- pruritus
- psychological dependence
- pyrosis (heartburn)
- rash
- renal papillary necrosis
- respiratory depression
- rhinitis
- serotonin syndrome
- SIADH
- sinus tachycardia
- sinusitis
- Stevens-Johnson syndrome
- stroke
- syncope
- thrombocytopenia
- thromboembolism
- tinnitus
- toxic epidermal necrolysis
- tremor
- urinary incontinence
- urinary retention
- urticaria
- vasculitis
- vertigo
- visual impairment
- vomiting
- weight loss
- withdrawal
- xerophthalmia
- xerostomia
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- abrupt discontinuation
- accidental exposure
- acute myocardial infarction
- adrenal insufficiency
- alcoholism
- anemia
- angina
- anticoagulant therapy
- asthma
- biliary tract disease
- bladder obstruction
- bone marrow suppression
- breast-feeding
- cardiac arrhythmias
- cardiac disease
- cardiomyopathy
- chemotherapy
- chronic obstructive pulmonary disease (COPD)
- coadministration with other CNS depressants
- coagulopathy
- constipation
- coronary artery bypass graft surgery (CABG)
- coronary artery disease
- corticosteroid therapy
- dental disease
- dental work
- diabetes mellitus
- diarrhea
- driving or operating machinery
- edema
- geriatric
- GI bleeding
- GI disease
- GI obstruction
- GI perforation
- head trauma
- heart failure
- hematological disease
- hemophilia
- hepatic disease
- hypertension
- hypothyroidism
- ileus
- immunosuppression
- increased intracranial pressure
- infection
- infertility
- inflammatory bowel disease
- intramuscular injections
- jaundice
- labor
- myocardial infarction
- myxedema
- nasal polyps
- neonatal opioid withdrawal syndrome
- neutropenia
- NSAID hypersensitivity
- obstetric delivery
- oliguria
- opiate agonist hypersensitivity
- peptic ulcer disease
- peripheral vascular disease
- polysorbate 80 hypersensitivity
- potential for overdose or poisoning
- pregnancy
- prostatic hypertrophy
- pulmonary disease
- renal disease
- renal failure
- renal impairment
- reproductive risk
- respiratory depression
- respiratory insufficiency
- salicylate hypersensitivity
- seizure disorder
- sepsis
- status asthmaticus
- stroke
- substance abuse
- surgery
- systemic lupus erythematosus (SLE)
- tachycardia
- thrombocytopenia
- thromboembolism
- tobacco smoking
- ulcerative colitis
- urethral stricture
- urinary retention
- urticaria
Interactions
- Abciximab
- Abiraterone
- Acebutolol
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Diphenhydramine
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Tramadol
- Acetohexamide
- Acrivastine; Pseudoephedrine
- Acyclovir
- Adefovir
- Aldesleukin, IL-2
- Alfentanil
- Aliskiren
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Aliskiren; Valsartan
- Almotriptan
- Alosetron
- Alpha-blockers
- Alprazolam
- Alteplase
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- Aluminum Hydroxide; Magnesium Hydroxide
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- Alvimopan
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- Amlodipine
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- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amobarbital
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- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amphetamine
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- Brompheniramine; Guaifenesin; Hydrocodone
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- Brompheniramine; Pseudoephedrine
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- Bupivacaine Liposomal
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- Buprenorphine; Naloxone
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- Busulfan
- Butabarbital
- Butorphanol
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- Carbamazepine
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- Carbetapentane; Guaifenesin
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbetapentane; Pyrilamine
- Carbinoxamine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Cardiac glycosides
- Cariprazine
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- Carmustine, BCNU
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- Castor Oil
- Cefotaxime
- Celecoxib
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- Cetirizine; Pseudoephedrine
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- Chlorambucil
- Chloramphenicol
- Chlorcyclizine
- Chlordiazepoxide
- Chlordiazepoxide; Clidinium
- Chloroprocaine
- Chlorothiazide
- Chlorpheniramine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Chlorpromazine
- Chlorpropamide
- Chlorthalidone
- Chlorthalidone; Clonidine
- Chlorzoxazone
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- Choline Salicylate; Magnesium Salicylate
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- Clozapine
- Cobicistat
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Colchicine; Probenecid
- Colistimethate, Colistin, Polymyxin E
- COMT inhibitors
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- Conjugated Estrogens; Bazedoxifene
- Corticosteroids
- Cortisone
- Crizotinib
- Crofelemer
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- Cyclobenzaprine
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- Dactinomycin, Actinomycin D
- Dalfopristin; Quinupristin
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- Danaparoid
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- Dexamethasone
- Dexchlorpheniramine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
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- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Diazepam
- Diazoxide
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- Diclofenac
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- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diltiazem
- Dimenhydrinate
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- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
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- Dipyridamole
- Docetaxel
- Dolasetron
- Donepezil
- Donepezil; Memantine
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- Dorzolamide; Timolol
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- Doxylamine
- Doxylamine; Pyridoxine
- Dronabinol
- Dronedarone
- Droperidol
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Drotrecogin Alfa
- Duloxetine
- Duvelisib
- Edoxaban
- Edrophonium
- Efavirenz
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- Elagolix
- Elagolix; Estradiol; Norethindrone acetate
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- Emtricitabine; Rilpivirine; Tenofovir alafenamide
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- grapefruit juice
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- Neomycin
- Neostigmine
- Nesiritide, BNP
- Netupitant, Fosnetupitant; Palonosetron
- Nevirapine
- Nicardipine
- Nilotinib
- Nitroglycerin
- Nitroprusside
- Non-Ionic Contrast Media
- Olanzapine
- Olmesartan
- Omacetaxine
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Ondansetron
- Oritavancin
- Orphenadrine
- Osilodrostat
- Oxaprozin
- Oxazepam
- Oxcarbazepine
- Oxybutynin
- Oxycodone
- Oxymorphone
- Ozanimod
- Paclitaxel
- Palbociclib
- Paliperidone
- Palonosetron
- Panobinostat
- Papaverine
- Paroxetine
- Pazopanib
- Pegaspargase
- Peginterferon Alfa-2b
- Pegvisomant
- Pemetrexed
- Penbutolol
- Pentamidine
- Pentazocine
- Pentazocine; Naloxone
- Pentobarbital
- Pentosan
- Pentostatin
- Perampanel
- Perindopril
- Perindopril; Amlodipine
- Perphenazine
- Perphenazine; Amitriptyline
- Pexidartinib
- Phenelzine
- Phenobarbital
- Phenoxybenzamine
- Phentermine; Topiramate
- Phentolamine
- Phenylephrine; Promethazine
- Phenytoin
- Photosensitizing agents (topical)
- Physostigmine
- Pimozide
- Pindolol
- Piroxicam
- Platelet Inhibitors
- Pneumococcal Vaccine, Polyvalent
- Polyethylene Glycol
- Polyethylene Glycol; Electrolytes
- Polyethylene Glycol; Electrolytes; Ascorbic Acid
- Polyethylene Glycol; Electrolytes; Bisacodyl
- Polymyxin B
- Polymyxins
- Posaconazole
- Potassium
- Pralatrexate
- Pramipexole
- Pramlintide
- Prasugrel
- Prazosin
- Prednisolone
- Prednisone
- Pregabalin
- Prilocaine
- Prilocaine; Epinephrine
- Primidone
- Probenecid
- Procaine
- Procarbazine
- Prochlorperazine
- Promethazine
- Propafenone
- Propantheline
- Propofol
- Propoxyphene
- Propranolol
- Pyridostigmine
- Quazepam
- Quetiapine
- Quinapril
- Quinidine
- Quinine
- Quinolones
- Ramelteon
- Ramipril
- Ranolazine
- Rasagiline
- Remifentanil
- Reserpine
- Reteplase, r-PA
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
- Rifampin
- Rifapentine
- Rifaximin
- Riluzole
- Risperidone
- Ritonavir
- Rivaroxaban
- Rivastigmine
- Rizatriptan
- Rolapitant
- Romidepsin
- Ropinirole
- Ropivacaine
- Rotigotine
- Rucaparib
- Sacubitril; Valsartan
- Safinamide
- Salicylates
- Salsalate
- Saquinavir
- Scopolamine
- Secobarbital
- Selective serotonin reuptake inhibitors
- Selegiline
- Selpercatinib
- Serotonin-Receptor Agonists
- Serotonin-Receptor Antagonists
- Sertraline
- Sevoflurane
- Sibutramine
- Sildenafil
- Simeprevir
- Skeletal Muscle Relaxants
- Sodium Hyaluronate, Hyaluronic Acid
- Sodium Oxybate
- Sodium Phosphate Monobasic Monohydrate; Sodium Phosphate Dibasic Anhydrous
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Solifenacin
- Sorbitol
- Sotalol
- Spironolactone
- St. John’s Wort, Hypericum perforatum
- Streptogramins
- Streptokinase
- Streptomycin
- Streptozocin
- Sufentanil
- Sulfinpyrazone
- Sulfonylureas
- Sulindac
- Sumatriptan
- Suvorexant
- Tacrine
- Tacrolimus
- Tapentadol
- Tasimelteon
- Tazemetostat
- Tedizolid
- Telaprevir
- Telavancin
- Telbivudine
- Telithromycin
- Telmisartan
- Telotristat Ethyl
- Temazepam
- Temozolomide
- Tenecteplase
- Teniposide
- Tenofovir Alafenamide
- Tenofovir, PMPA
- Terazosin
- Terbinafine
- Tetrabenazine
- Tetracaine
- Tezacaftor; Ivacaftor
- Thalidomide
- Thiazide diuretics
- Thioguanine, 6-TG
- Thiopental
- Thioridazine
- Thiothixene
- Thrombolytic Agents
- Ticagrelor
- Ticlopidine
- Timolol
- Tinzaparin
- Tipranavir
- Tirofiban
- Tizanidine
- tobacco
- Tobramycin
- Tolazamide
- Tolbutamide
- Tolmetin
- Tolterodine
- Topiramate
- Torsemide
- Tositumomab
- Tramadol
- Trandolapril
- Trandolapril; Verapamil
- Tranylcypromine
- Trazodone
- Treprostinil
- Tretinoin, ATRA
- Triamcinolone
- Triamterene
- Triazolam
- Tricyclic antidepressants
- Trifluoperazine
- Trihexyphenidyl
- Trimethobenzamide
- Triprolidine
- Trospium
- Tucatinib
- Urea
- Urokinase
- Valacyclovir
- Valerian, Valeriana officinalis
- Valganciclovir
- Valproic Acid, Divalproex Sodium
- Valsartan
- Vancomycin
- Vasodilators
- Vemurafenib
- Venlafaxine
- Verapamil
- Verteporfin
- Vigabatrin
- Vilazodone
- Vincristine
- Vincristine Liposomal
- Vorapaxar
- Voriconazole
- Vorinostat
- Vortioxetine
- Voxelotor
- Warfarin
- Zafirlukast
- Zaleplon
- Ziconotide
- Ziprasidone
- Zolmitriptan
- Zolpidem
