Hydrochlorothiazide Telmisartan Brand Name– Micardis HCT
What is Hydrochlorothiazide Telmisartan
Hydrochlorothiazide Telmisartan are combined together in a once daily oral preparation to manage hypertension.
Hydrochlorothiazide is a thiazide diuretic. Similar to the prototype losartan, telmisartan is a specific and selective angiotensin II antagonist. The half-life of telmisartan (24 hours) is longer than other available angiotensin II antagonists. Compared to losartan, telmisartan is not metabolized to an active metabolite, and lacks uricosuric effects.
Because AT1 receptors are nearly saturated at the starting doses for most angiotensin II antagonists, the antihypertensive dose-response curve for these drugs is nonlinear, with proportionally small decreases in blood pressure attained with increased dosage.
Greater antihypertensive efficacy is generally achieved by adding a small dose of hydrochlorothiazide to the angiotensin II antagonist. Telmisartan tends to reverse the potassium loss associated with HCTZ.
Because telmisartan does not inhibit angiotensin converting enzyme (ACE), it does not result in bradykinin accumulation, which is theorized to cause cough and angioedema associated with ACE inhibitors.
However, angioedema has been rarely associated with telmisartan or other angiotensin II antagonists.
Micardis® HCT was approved by the FDA on November 17, 2000.
Indications
- hypertension
For the treatment of hypertension in patients who do not respond to monotherapy
Side Effects
- abdominal pain
- agranulocytosis
- alopecia
- anaphylactoid reactions
- anemia
- angioedema
- aplastic anemia
- asthenia
- atrial fibrillation
- azotemia
- back pain
- blurred vision
- bradycardia
- chest pain (unspecified)
- cough
- diabetes mellitus
- diaphoresis
- diarrhea
- dizziness
- dyspepsia
- edema
- elevated hepatic enzymes
- eosinophilia
- erythema multiforme
- exfoliative dermatitis
- fatigue
- fever
- glycosuria
- gout
- headache
- heart failure
- hemolytic anemia
- hepatitis
- hyperbilirubinemia
- hypercalcemia
- hypercholesterolemia
- hyperglycemia
- hyperkalemia
- hypertriglyceridemia
- hyperuricemia
- hypokalemia
- hypomagnesemia
- hyponatremia
- hypovolemia
- impotence (erectile dysfunction)
- infection
- influenza
- jaundice
- leukopenia
- metabolic alkalosis
- muscle cramps
- myalgia
- myocardial infarction
- myopia
- nausea
- nephrolithiasis
- ocular hypertension
- oliguria
- orthostatic hypotension
- pancreatitis
- pancytopenia
- pharyngitis
- photosensitivity
- pruritus
- purpura
- rash
- renal failure (unspecified)
- rhabdomyolysis
- sialadenitis
- sinus tachycardia
- sinusitis
- Stevens-Johnson syndrome
- syncope
- teratogenesis
- thrombocytopenia
- toxic epidermal necrolysis
- urticaria
- vomiting
- weakness
- xanthopsia
Monitoring Parameters
- blood glucose
- blood pressure
- LFTs
- serum bilirubin (total and direct)
- serum creatinine/BUN
- serum electrolytes
- serum uric acid
Contraindications
- ACE-inhibitor induced angioedema
- angioedema
- anuria
- asthma
- breast-feeding
- children
- diabetes mellitus
- electrolyte imbalance
- geriatric
- gout
- heart failure
- hepatic disease
- hypercalcemia
- hyperglycemia
- hyperkalemia
- hyperuricemia
- hypokalemia
- hypomagnesemia
- hyponatremia
- hypotension
- hypovolemia
- orthostatic hypotension
- pancreatitis
- penicillin hypersensitivity
- pregnancy
- renal artery stenosis
- renal disease
- renal failure
- renal impairment
- sulfonamide hypersensitivity
- sunlight (UV) exposure
- surgery
- sympathectomy
- syncope
- systemic lupus erythematosus (SLE)
- thiazide diuretic hypersensitivity
Interactions
- Acarbose
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Pseudoephedrine
- Acetaminophen; Tramadol
- Acetazolamide
- Acetohexamide
- Aclidinium; Formoterol
- Acrivastine; Pseudoephedrine
- Albiglutide
- Albuterol
- Albuterol; Ipratropium
- Aldesleukin, IL-2
- Alemtuzumab
- Alendronate; Cholecalciferol
- Alfentanil
- Aliskiren
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Aliskiren; Valsartan
- Allopurinol
- Alogliptin
- Alogliptin; Metformin
- Alogliptin; Pioglitazone
- Alpha-glucosidase Inhibitors
- Alprostadil
- Amifostine
- Amiloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Aminolevulinic Acid
- Amiodarone
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amobarbital
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amphetamine; Dextroamphetamine Salts
- Amphotericin B
- Amphotericin B cholesteryl sulfate complex (ABCD)
- Amphotericin B lipid complex (ABLC)
- Amphotericin B liposomal (LAmB)
- Amyl Nitrite
- Angiotensin II
- Angiotensin-converting enzyme inhibitors
- Anticholinergics
- Apomorphine
- Apraclonidine
- Arformoterol
- Aripiprazole
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- Articaine; Epinephrine
- Asenapine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Atracurium
- Atropine
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Atropine; Edrophonium
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Baclofen
- Barbiturates
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Belladonna; Opium
- Benazepril
- Benazepril; Hydrochlorothiazide, HCTZ
- Benzhydrocodone; Acetaminophen
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Benzphetamine
- Benztropine
- Beta-agonists
- Bortezomib
- Bosentan
- Brexpiprazole
- Brompheniramine; Carbetapentane; Phenylephrine
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- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Budesonide; Formoterol
- Buprenorphine
- Buprenorphine; Naloxone
- Cabergoline
- Calcium
- Calcium Phosphate, Supersaturated
- Calcium; Vitamin D
- Canagliflozin
- Canagliflozin; Metformin
- Captopril
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- Carbamazepine
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- Cardiac glycosides
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- Celecoxib
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- Chloroprocaine
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- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Chlorpropamide
- Cholestyramine
- Cidofovir
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- Citalopram
- Clindamycin; Tretinoin
- Clopidogrel
- Clozapine
- Co-Enzyme Q10, Ubiquinone
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- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
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- Conivaptan
- Corticosteroids
- Cosyntropin
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- Cyclosporine
- Dapagliflozin
- Dapagliflozin; Metformin
- Dapagliflozin; Saxagliptin
- Desloratadine; Pseudoephedrine
- Desvenlafaxine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexlansoprazole
- Dexmethylphenidate
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Dextromethorphan; Quinidine
- Diazoxide
- Dichlorphenamide
- Diclofenac
- Diclofenac; Misoprostol
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- Diethylpropion
- Diflunisal
- Digitoxin
- Digoxin
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
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- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Diphenhydramine; Phenylephrine
- Dobutamine
- Dofetilide
- Dolasetron
- Donepezil; Memantine
- Dopamine
- Doxacurium
- Droperidol
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Dulaglutide
- Duloxetine
- Empagliflozin
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Enalapril, Enalaprilat
- Enalapril; Felodipine
- Enalapril; Hydrochlorothiazide, HCTZ
- Enflurane
- Ephedrine
- Epinephrine
- Eplerenone
- Epoprostenol
- Ergocalciferol, Vitamin D2
- Ertugliflozin; Metformin
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- Escitalopram
- Esomeprazole
- Esomeprazole; Naproxen
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- Estradiol Cypionate; Medroxyprogesterone
- Ethanol
- Etodolac
- Etomidate
- Exenatide
- Famotidine; Ibuprofen
- Fenoprofen
- Fentanyl
- Fexofenadine; Pseudoephedrine
- Fish Oil, Omega-3 Fatty Acids (Dietary Supplements)
- Flavoxate
- Fluconazole
- Fluocinolone; Hydroquinone; Tretinoin
- Fluoxetine
- Fluoxetine; Olanzapine
- Flurbiprofen
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Fluvoxamine
- Formoterol
- Formoterol; Mometasone
- Fosinopril
- Fosinopril; Hydrochlorothiazide, HCTZ
- Fospropofol
- Gallium Ga 68 Dotatate
- General anesthetics
- Glimepiride
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- Glipizide
- Glipizide; Metformin
- Glyburide
- Glyburide; Metformin
- Glycopyrrolate
- Glycopyrrolate; Formoterol
- Granisetron
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Phenylephrine
- Guaifenesin; Pseudoephedrine
- Halobetasol; Tazarotene
- Halofantrine
- Haloperidol
- Halothane
- Homatropine; Hydrocodone
- Hydralazine; Isosorbide Dinitrate, ISDN
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydromorphone
- Hyoscyamine
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibritumomab Tiuxetan
- Ibuprofen
- Ibuprofen lysine
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Icosapent ethyl
- Iloperidone
- Iloprost
- Inamrinone
- Incretin Mimetics
- Indacaterol
- Indacaterol; Glycopyrrolate
- Indapamide
- Indomethacin
- Inotersen
- Insulin Degludec; Liraglutide
- Insulin Glargine; Lixisenatide
- Insulins
- Intravenous Lipid Emulsions
- Isocarboxazid
- Isoflurane
- Isoproterenol
- Isosorbide Dinitrate, ISDN
- Isosorbide Mononitrate
- Ketamine
- Ketoprofen
- Ketorolac
- Lansoprazole
- Lansoprazole; Naproxen
- Lesinurad; Allopurinol
- Levalbuterol
- Levodopa
- Levomethadyl
- Levomilnacipran
- Levorphanol
- Linagliptin
- Linagliptin; Metformin
- Liraglutide
- Lisdexamfetamine
- Lisinopril
- Lithium
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- Loop diuretics
- Loratadine; Pseudoephedrine
- Lovastatin; Niacin
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- Magnesium Salts
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- Mannitol
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- Mefenamic Acid
- Meglitinides
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- Meperidine; Promethazine
- Mequinol; Tretinoin
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- Metaproterenol
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
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- Methazolamide
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- Methenamine; Sodium Acid Phosphate
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methohexital
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- Methscopolamine
- Methylphenidate
- Metoclopramide
- Midodrine
- Miglitol
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- Milrinone
- Mirtazapine
- Mivacurium
- Moexipril
- Morphine
- Morphine; Naltrexone
- Mycophenolate
- Nabumetone
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Nateglinide
- Nefazodone
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- Neuromuscular blockers
- Niacin, Niacinamide
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- Nitrates
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- Nonsteroidal antiinflammatory drugs
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- Octreotide
- Olanzapine
- Olodaterol
- Omeprazole
- Omeprazole; Amoxicillin; Rifabutin
- Omeprazole; Sodium Bicarbonate
- Ondansetron
- Oprelvekin, rh-IL-11
- Oxaprozin
- Oxybutynin
- Oxycodone
- Oxymetazoline
- Oxymorphone
- Paliperidone
- Pancuronium
- Pantoprazole
- Paroxetine
- Pasireotide
- Pentamidine
- Pentazocine
- Pentazocine; Naloxone
- Pentoxifylline
- Perindopril
- Perindopril; Amlodipine
- Phendimetrazine
- Phenelzine
- Phenothiazines
- Phentermine
- Phentermine; Topiramate
- Phenylephrine
- Phenylephrine; Promethazine
- Photosensitizing agents (topical)
- Pimozide
- Pioglitazone
- Pirbuterol
- Piroxicam
- Polycarbophil
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- Polyethylene Glycol; Electrolytes; Ascorbic Acid
- Porfimer
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- Potassium Phosphate; Sodium Phosphate
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- Procaine
- Propantheline
- Propofol
- Pseudoephedrine
- Quetiapine
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- Quinidine
- Rabeprazole
- Ramipril
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- Salmeterol
- Saxagliptin
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- Solifenacin
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