What's on this Page
Hepatitis B Vaccine Recombinant Brand Names
Engerix-B | H-B-Vax | HEPLISAV-B | RDNA H-B Vax II | Recombivax HB
What is Hepatitis B Vaccine Recombinant
Vaccines against hepatitis B surface antigen (HBsAg) are produced by yeast cells utilizing recombinant technology designed for intramuscular or subcutaneous (Engerix-B and Recombivax HB only) administration.
The recombinant hepatitis B vaccines contain no human blood products.
Engerix-B and Heplisav-B reportedly contain not more than 5% yeast proteins while Recombivax HB contains not more than 1%.
Engerix-B and Recombivax HB are indicated for hepatitis B prophylaxis in all ages and can be used in conjunction with hepatitis B immune globulin (HBIG) for postexposure prophylaxis. Heplisav-B is indicated for hepatitis B prophylaxis in adults 18 years of age and older.
The first dose of the hepatitis B vaccine (Engerix-B or Recombivax HB) should be given to all neonates within 24 hours of birth.
For infants born to hepatitis B surface antigen (HBsAg) positive mothers, the hepatitis B vaccine and hepatitis B immune globulin (HBIG) should be administered within 12 hours of birth.
If the mother’s HBsAg status is unknown, the hepatitis B vaccine should be administered to all neonates within 12 hours of birth.
Additionally, HBIG should be administered within 12 hours to all neonates weighing less than 2 kg and within 7 days if the mother is determined to be HBsAg positive in neonates weighing more than 2 kg
Indications
- hepatitis B prophylaxis
Side Effects
- abdominal pain
- agitation
- alopecia
- anaphylactic shock
- anaphylactoid reactions
- angioedema
- anorexia
- arthralgia
- back pain
- chills
- constipation
- diarrhea
- dizziness
- dyspepsia
- dyspnea
- ecchymosis
- encephalopathy
- erythema
- erythema multiforme
- erythema nodosum
- fatigue
- fever
- flushing
- Guillain-Barre syndrome
- headache
- hypoesthesia
- hypotension
- injection site reaction
- insomnia
- irritability
- lichen planus-like eruption
- lymphadenopathy
- malaise
- migraine
- myalgia
- myelitis
- myocardial infarction
- nausea
- neuritis
- optic neuritis
- paresthesias
- peripheral neuropathy
- petechiae
- pruritus
- purpura
- rash
- seizures
- serum sickness
- Stevens-Johnson syndrome
- syncope
- thrombocytopenia
- tinnitus
- urticaria
- vasculitis
- vertigo
- vomiting
- weakness
Monitoring Parameters
- hepatitis B serology
Contraindications
- anticoagulant therapy
- breast-feeding
- cardiac disease
- chemotherapy
- coagulopathy
- dialysis
- fever
- hemophilia
- human immunodeficiency virus (HIV) infection
- immunosuppression
- infection
- intravenous administration
- laboratory test interference
- latex hypersensitivity
- neonates
- pregnancy
- premature neonates
- renal disease
- renal failure
- subcutaneous administration
- thrombocytopenia
- vitamin K deficiency
- yeast hypersensitivity
Interactions
- Hepatitis B Immune Globulin, HBIG
- Ocrelizumab
- Siponimod
