Guanidine Brand Name– Guanidine
What is Guanidine
Guanidine is an oral cholinergic muscle stimulant.
Guanidine is indicated for the reduction of the symptoms of muscle weakness and easy fatigability associated with the myasthenic syndrome of Lambert-Eaton. Guanidine is not indicated for use in myasthenia gravis.
Lambert-Eaton can usually be differentiated from myasthenia gravis by the presence of small cell carcinoma of the lung, but myography may be necessary for a definitive diagnosis.
Gastrointestinal adverse events (e.g., nausea, diarrhea, abdominal cramping) may preclude use in some patients.
Guanidine has been used clinically since 1939.
Indications
- Lambert-Eaton syndrome
For the reduction of the symptoms of muscle weakness and easy fatigability associated with Lambert-Eaton syndrome
Side Effects
- anemia
- anorexia
- anxiety
- ataxia
- atrial fibrillation
- confusion
- diarrhea
- ecchymosis
- elevated hepatic enzymes
- emotional lability
- fever
- flushing
- folliculitis
- gastritis
- hallucinations
- hyperhidrosis
- hypotension
- interstitial nephritis
- irritability
- leukopenia
- nausea
- palpitations
- paresthesias
- petechiae
- pharyngitis
- psychosis
- purpura
- rash
- renal tubular necrosis
- restlessness
- sinus tachycardia
- thrombocytopenia
- tremor
- xerosis
- xerostomia
Monitoring Parameters
- CBC with differential
- neurologic function
- serum creatinine
- urinalysis
Contraindications
- anemia
- bone marrow suppression
- breast-feeding
- children
- GI disease
- hepatic disease
- infants
- leukopenia
- neonates
- peptic ulcer disease
- pregnancy
- psychosis
- renal impairment
- thrombocytopenia
Interactions
- Ambenonium Chloride
- Amoxapine
- Anticholinergics
- Atropine
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Atropine; Edrophonium
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Belladonna; Opium
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Benztropine
- Bethanechol
- Carbamazepine
- Cevimeline
- Chlordiazepoxide; Clidinium
- Chlorpromazine
- Cholinesterase inhibitors
- Clozapine
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Dextromethorphan; Promethazine
- Dicyclomine
- Disopyramide
- Donepezil
- Donepezil; Memantine
- Edrophonium
- Felbamate
- Flavoxate
- Fluphenazine
- Galantamine
- Glycopyrrolate
- Glycopyrrolate; Formoterol
- Homatropine; Hydrocodone
- Hyoscyamine
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Indacaterol; Glycopyrrolate
- Maprotiline
- Mepenzolate
- Meperidine; Promethazine
- Mesoridazine
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methscopolamine
- Neostigmine
- Oxybutynin
- Perphenazine
- Perphenazine; Amitriptyline
- Phenothiazines
- Phenylephrine; Promethazine
- Physostigmine
- Pilocarpine
- Pralidoxime
- Prochlorperazine
- Promethazine
- Propantheline
- Pyridostigmine
- Rivastigmine
- Scopolamine
- Sulfinpyrazone
- Tacrine
- Thiethylperazine
- Thioridazine
- Tricyclic antidepressants
- Trifluoperazine
- Trihexyphenidyl
- Trospium
