Guanabenz Brand Name– Wytensin
What is Guanabenz
Guanabenz is a centrally active alpha-adrenergic agonist used to treat hypertension.
The drug is structurally and pharmacologically similar to clonidine and exerts comparable physiologic effects.
It is as effective in controlling blood pressure in hypertensive patients as other adrenergic inhibitors including methyldopa, clonidine, propranolol, or pindolol.
Guanabenz was approved for clinical use by the FDA in September 1982.
Indications
- hypertension
Side Effects
- abdominal pain
- angina
- ataxia
- AV block
- blurred vision
- bradycardia
- constipation
- depression
- diaphoresis
- diarrhea
- dizziness
- drowsiness
- dysgeusia
- dyspnea
- edema
- gynecomastia
- headache
- impotence (erectile dysfunction)
- increased urinary frequency
- insomnia
- libido decrease
- myalgia
- nasal congestion
- nausea
- palpitations
- pruritus
- rash
- tinnitus
- vomiting
- weakness
- withdrawal
- xerostomia
Monitoring Parameters
- blood pressure
Contraindications
- abrupt discontinuation
- breast-feeding
- cardiac disease
- cerebrovascular disease
- geriatric
- hepatic disease
- MAOI therapy
- myocardial infarction
- pregnancy
Interactions
- Acebutolol
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Propoxyphene
- Acetaminophen; Pseudoephedrine
- Acetazolamide
- Acrivastine; Pseudoephedrine
- Aldesleukin, IL-2
- Alemtuzumab
- Alfentanil
- Alprazolam
- Alprostadil
- Amifostine
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amlodipine; Celecoxib
- Amoxapine
- Amphetamine
- Amphetamine; Dextroamphetamine
- Amyl Nitrite
- Apomorphine
- Apraclonidine
- Aripiprazole
- Articaine; Epinephrine
- Asenapine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Oxycodone
- Atenolol
- Atenolol; Chlorthalidone
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Baclofen
- Belladonna; Opium
- Bendroflumethiazide; Nadolol
- Benzodiazepines
- Benzphetamine
- Beta-blockers
- Betaxolol
- Bisoprolol
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Bortezomib
- Brexpiprazole
- Brimonidine; Timolol
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Dextromethorphan; Phenylephrine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Cannabidiol
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbidopa; Levodopa
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Carbonic anhydrase inhibitors
- Cariprazine
- Carteolol
- Carvedilol
- Celecoxib
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chlophedianol; Guaifenesin; Phenylephrine
- Chlordiazepoxide
- Chlordiazepoxide; Clidinium
- Chloroprocaine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Chlorpromazine
- Clomipramine
- Clonazepam
- Clorazepate
- Clozapine
- Co-Enzyme Q10, Ubiquinone
- Cocaine
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Desipramine
- Desloratadine; Pseudoephedrine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmethylphenidate
- Dextroamphetamine
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Diazepam
- Diazoxide
- Diclofenac
- Diclofenac; Misoprostol
- Diethylpropion
- Diflunisal
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Diphenhydramine; Phenylephrine
- Dobutamine
- Dopamine
- Dorzolamide; Timolol
- Doxepin
- Duloxetine
- Enflurane
- Ephedrine
- Epinephrine
- Epoprostenol
- Esmolol
- Esomeprazole; Naproxen
- Estazolam
- Estradiol
- Estradiol Cypionate; Medroxyprogesterone
- Etodolac
- Etomidate
- Famotidine; Ibuprofen
- Fenoprofen
- Fentanyl
- Fexofenadine; Pseudoephedrine
- Fish Oil, Omega-3 Fatty Acids (Dietary Supplements)
- Fluoxetine; Olanzapine
- Fluphenazine
- Flurazepam
- Flurbiprofen
- Fospropofol
- General anesthetics
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Phenylephrine
- Guaifenesin; Pseudoephedrine
- Haloperidol
- Halothane
- Homatropine; Hydrocodone
- Hydralazine; Isosorbide Dinitrate, ISDN
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydromorphone
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Iloperidone
- Iloprost
- Imipramine
- Indomethacin
- Intravenous Lipid Emulsions
- Isocarboxazid
- Isoflurane
- Isoproterenol
- Isosorbide Dinitrate, ISDN
- Isosorbide Mononitrate
- Ketamine
- Ketoprofen
- Ketorolac
- Labetalol
- Lansoprazole; Naproxen
- Levobetaxolol
- Levobunolol
- Levodopa
- Levorphanol
- Linezolid
- Lisdexamfetamine
- Lofexidine
- Loratadine; Pseudoephedrine
- Lorazepam
- Lovastatin; Niacin
- Lurasidone
- Maprotiline
- Meclofenamate Sodium
- Mefenamic Acid
- Meloxicam
- Meperidine
- Meperidine; Promethazine
- Mepivacaine; Levonordefrin
- Mesoridazine
- Mestranol; Norethindrone
- Methadone
- Methamphetamine
- Methazolamide
- Methylphenidate
- Metoprolol
- Midazolam
- Midodrine
- Milrinone
- Monoamine oxidase inhibitors
- Morphine
- Morphine; Naltrexone
- Nabumetone
- Nadolol
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Nebivolol
- Nebivolol; Valsartan
- Nesiritide, BNP
- Niacin, Niacinamide
- Niacin; Simvastatin
- Nitrates
- Nitroglycerin
- Nitroprusside
- Nonsteroidal antiinflammatory drugs
- Norepinephrine
- Nortriptyline
- Olanzapine
- Opiate Agonists
- Oxaprozin
- Oxazepam
- Oxycodone
- Oxymetazoline
- Oxymorphone
- Paliperidone
- Pemoline
- Penbutolol
- Pentoxifylline
- Perphenazine
- Perphenazine; Amitriptyline
- Phendimetrazine
- Phenelzine
- Phenothiazines
- Phentermine
- Phentermine; Topiramate
- Phenylephrine
- Phenylephrine; Promethazine
- Pindolol
- Piroxicam
- Prazosin
- Prilocaine; Epinephrine
- Procainamide
- Procaine
- Prochlorperazine
- Promethazine
- Propofol
- Propoxyphene
- Propranolol
- Protriptyline
- Pseudoephedrine
- Quazepam
- Quinidine
- Racepinephrine
- Rasagiline
- Remifentanil
- Risperidone
- Ritodrine
- Rofecoxib
- Selegiline
- Sevoflurane
- Silodosin
- Sotalol
- Sufentanil
- Sulindac
- Sympathomimetics
- Temazepam
- Tetrabenazine
- Tetracaine
- Thiethylperazine
- Thioridazine
- Thiothixene
- Timolol
- Tizanidine
- Tolmetin
- Tranylcypromine
- Triazolam
- Tricyclic antidepressants
- Trifluoperazine
- Trimipramine
- Valdecoxib
- Yohimbine
- Ziprasidone
